PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

'Exciting discovery' could aid frontline spinal injury treatment

Scientists a step closer to treating harmful inflammation after spinal cord injury

2015-04-23
(Press-News.org) Rapid treatment with a new anti-inflammatory could have a major impact on recovery from spinal cord injury, University of Queensland researchers have found.

UQ School of Biomedical Sciences' Dr Marc Ruitenberg and PhD student Ms Faith Brennan said they made the discovery during laboratory trials with an experimental drug.

Ms Brennan said that excessive inflammation caused additional damage in spinal cord injuries and hindered recovery.

"We found that a molecule called C5aR exacerbates inflammation and tissue damage after spinal cord injury," she said.

"Our study shows that drugs inhibiting C5aR can improve recovery when administered early after injury.

"This exciting discovery could form the basis for new frontline therapies to treat patients with spinal cord trauma."

Dr Ruitenberg said there was a critical time window for this new treatment.

"What we also discovered is that this molecule, C5aR, has multiple roles and is also needed for repair processes undertaken by astrocytes, a specialised type of cell in the spinal cord," he said.

"Astrocytes normally multiply in response to injury, which is an essential process to form a barrier between damaged and healthy tissue.

"Any long-term interference with this process could therefore make things worse.

"Our challenge was to find out how long treatment with the new drug could be continued before its beneficial effects were lost, and also to understand why this occurred so that adverse side-effects could be prevented."

SpinalCure Australia CEO Mr Duncan Wallace, whose organisation supports the UQ research, said the study was a great step towards developing an effective treatment for spinal cord injury.

"It takes us closer to the day when a spinal cord injury is no longer a life sentence," he said.

The research is published in the Journal of Neuroscience (The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury) on 22 April 2015.

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Researchers discover never-before-seen tick-borne disease

2015-04-22
Tick-borne diseases are a major public health problem around the world. Ticks carry and transmit a variety of microbes that cause disease. These illnesses, which include Lyme disease, Rocky Mountain spotted fever, and Tularemia, can cause a variety of symptoms, often serious and sometimes deadly. Now, just in time for spring and the explosion of ticks in forests, lawns and trails, a new study by researchers from China and the University of Maryland School of Medicine (UM SOM) has uncovered a never-before-seen illness transmitted by ticks. It's possible that the disease ...

Stem cells that prevent birth defect also repair facial injury

2015-04-22
Researchers have pinpointed a primary cause of a rare skull disorder in infants, and the discovery could help wounded soldiers, car-wreck victims and other patients recover from disfiguring facial injuries. "This has a lot more implication than what we initially thought," said Yang Chai, a lead researcher on the study at the Herman Ostrow School of Dentistry of USC. "We can take advantage of these stem cells not only to repair a birth defect, but to provide facial regeneration for veterans or other people who have suffered traumatic injury." Chai predicted such treatment ...

More Americans at risk from strong earthquakes, says new report

2015-04-22
SAN FRANCISCO--More than 143 million Americans living in the 48 contiguous states are exposed to potentially damaging ground shaking from earthquakes, with as many as 28 million people likely to experience strong shaking during their lifetime, according to research discussed at the annual meeting of Seismological Society of America. The report puts the average long-term value of building losses from earthquakes at $4.5 billion per year, with roughly 80 percent of losses attributed to California, Oregon and Washington. "This analysis of data from the new National Seismic ...

Study illuminates role of cancer drug decitabine in repairing damaged cells

2015-04-22
WEST LAFAYETTE, Ind. - A Purdue University study sheds light on how cell damage is reversed by the cancer drug decitabine and identifies a potential biomarker that could indicate a patient's stage of cancer and response to treatment. A team led by Joseph Irudayaraj, professor of agricultural and biological engineering, showed that decitabine combats some of the effects of cancer by taking the place of the nucleotide cytosine at specific locations on a replicating DNA strand. By mimicking cytosine, the drug helps "tame" cancerous cells by turning on tumor suppressor genes ...

Study shows how breast milk protects against severe intestinal disease in preemies

2015-04-22
The immune-boosting properties of breast milk have long been known. Now a team of scientists led by Johns Hopkins pediatric surgeon-in-chief David Hackam, M.D., Ph.D., says experiments in mice reveal how breast milk works to ward off the development of necrotizing enterocolitis (NEC), a devastating intestinal disorder that affects 12 percent of premature babies and claims the lives of one in four of those who have it. If affirmed in human studies, the experiments could pave the way to new preventive approaches to stave off NEC in premature babies and spark the development ...

Notre Dame paper examines the clinical potential of microvesicles

2015-04-22
Over the past few years, extracellular vesicles, or membrane sacs secreted from cells, have emerged as important mediators by which cells communicate with their surroundings to regulate a diverse range of biological processes. In addition, specialized roles for extracellular vesicles are beginning to be recognized in various diseases including cancer, infectious diseases and neurodegenerative disorders. Moreover, engineered extracellular vesicles are likely to have applications in drug delivery. The laboratory of Crislyn D'Souza-Schorey, Morris Pollard Professor and Chair ...

Sugary drinks boost risk factors for heart disease, study shows

2015-04-22
Beverages sweetened with low, medium and high amounts of high-fructose corn syrup significantly increase risk factors for cardiovascular disease, even when consumed for just two weeks by young, healthy men and women, reports a team of researchers at the University of California, Davis. The study is the first to demonstrate a direct, dose-dependent relationship between the amount of added sugar consumed in sweetened beverages and increases in specific risk factors for cardiovascular disease. The data reinforce evidence from an earlier epidemiological study showing that ...

Better social media techniques increase fan interest, engagement

2015-04-22
COLUMBIA, Mo. -Due to the ever-increasing number of people using social media sites such as Facebook and Twitter, businesses and organizations, such as professional sports teams, are expanding their marketing and communication efforts to engage people with their brands through those sites. Now, Nicholas Watanabe, an assistant teaching professor at the University of Missouri, along with colleagues from MU and Louisiana State University, analyzed Major League Baseball (MLB) teams' use of Twitter to engage and increase fan interest. They found that the more individual teams ...

Researchers see promise in treatment to reduce incidence of dementia after TBI

2015-04-22
LEXINGTON, KY. (Apr. 22, 2015) -- It was once thought that effects of a mild head injury -- dizziness, headaches, memory problems -- were only temporary, and the brain would heal over time. However, while the long-term consequences of head trauma are not fully known, growing evidence suggests that even a mild head injury can increase the risk for later-in-life development of dementias such as Alzheimer's disease. Researchers at the University of Kentucky's Sanders-Brown Center on Aging have been attempting to understand the cascade of events following mild head injury ...

This week from AGU: Undersea eruptions, Shale boom and ozone pollution, Titan's atmosphere

2015-04-22
From AGU's blogs: Volcanic soundscapes reveal differences in undersea eruptions New research matching different types of underwater volcanic eruptions with their unique sound signatures could help scientists better detect and understand emissions occurring on the seafloor. From Eos.org: Is the Shale Boom Reversing Progress in Curbing Ozone Pollution? Concentrations of volatile organic compounds--precursors to ground-level ozone formation--are on the rise in areas over and downwind of a major shale oil and gas field in Texas. From AGU's journals: When the Sun ...

LAST 30 PRESS RELEASES:

New research boosts future whooping cough vaccines

Mechanistic understanding could enable better fast-charging batteries

No bones about it: new details about skeletal cell aging revealed

UNM scientists discover how nanoparticles of toxic metal used in MRI scans infiltrate human tissue

UMaine research examines best methods for growing Atlantic sea scallops

Medical cannabis could speed recovery, especially at community recovery homes

Study assesses U.S. image amid weakening of democracy

Two scientific researchers to receive 2025 Ralph L. Sacco Scholarships for Brain Health

Researchers improve chemical reaction that underpins products from foods to fuels

Texas Tech to develop semiconductor power devices through $6 million grant

Novel genomic screening tool enables precision reverse-engineering of genetic programming in cells

Hot Schrödinger cat states created

How cells repair their power plants

Oxygen is running low in inland waters—and humans are to blame

ACP’s Best Practice Advice addresses use of cannabis, cannabinoids for chronic noncancer pain

Beyond photorespiration: A systematic approach to unlocking enhanced plant productivity

How a small number of mutations can fuel outbreaks of western equine encephalitis virus

Exposure to wildfire smoke linked with worsening mental health conditions

Research uncovers hidden spread of one of the most common hospital-associated infections

Many older adults send their doctors portal messages, but who pays?

Fine particulate matter from 2020 California wildfires and mental health–related emergency department visits

Gender inequity in institutional leadership roles in US academic medical centers

Pancreatic cells ‘remember’ epigenetic precancerous marks without genetic sequence mutations

Rare combination of ovarian tumors found in one patient

AI-driven clinical recommendations may aid physician decision making to improve quality of care

Artificial intelligence has potential to aid physician decisions during virtual urgent care

ACP and Annals of Internal Medicine present breaking scientific news at ACP’s Internal Medicine Meeting 2025

New study reveals polymers with flawed fillers boost heat transfer in plastics

Signs identified that precede sudden arrhythmic death syndrome in young people

Discovery of bacteria's defence against viruses becomes a piece of the puzzle against resistance

[Press-News.org] 'Exciting discovery' could aid frontline spinal injury treatment
Scientists a step closer to treating harmful inflammation after spinal cord injury