(Press-News.org) April 25, 2015, Vienna, Austria: Preliminary data from an ongoing study revealed today at The International Liver Congress™ 2015 suggest that a combination of three direct-acting antivirals (DAAs) is well tolerated in patients with severe renal impairment or end-stage renal disease when used either with or without ribavirin. In addition, the combination led to rapid hepatitis C viral load suppression with no virological failures seen in the preliminary data from the ongoing open-label study.
In the study, treatment naïve non-cirrhotic adults with chronic HCV GT1 infection and chronic kidney disease (CKD) classified as stage 4 or stage 5, received 12 weeks of treatment with ombitasvir / paritaprevir / ritonavir and dasabuvir (3D) either with or without ribavirin. There was a 24-week post-treatment follow-up period. As of February 18 2015, 17 of a planned 20 patients in Cohort 1 had received treatment and six had completed treatment. The combination has been well tolerated to date, with no treatment-related serious adverse events, one hemoglobin decline to END
Preliminary safety findings: IFN-free DAA combination in chronic HCV patients
Safety findings from the ongoing RUBY-1 study evaluating ombitasvir / paritaprevir / ritonavir in combination with dasabuvir (3D) in chronic hepatitis C virus (HCV) genotype 1 (GT1) patients with severe renal impairment or end-stage renal disease
2015-04-27
ELSE PRESS RELEASES FROM THIS DATE:
Outsmarting smartphones: Technology reduces distracted driving among teens
2015-04-27
SAN DIEGO - Technology can bolster efforts by parents, lawmakers and insurance companies to reduce distracted driving among novice teen drivers, according to a study to be presented Monday, April 27 at the Pediatric Academic Societies (PAS) annual meeting in San Diego.
Motor vehicle crashes are the leading cause of accidental death for teens, according to the Centers for Disease Control and Prevention. Studies suggest that the use of voice/text devices while driving is associated with crash risks up to 24 times higher than when cell phones are not used to talk or text ...
Detection of critical heart disease before birth lags among poor
2015-04-27
SAN DIEGO - Parents-to-be often look forward to prenatal ultrasounds, when they get the first glimpse of their baby and perhaps learn their child's sex. Ultrasound technology also allows for the detection of birth defects and other abnormalities before a baby is born.
While prenatal ultrasounds are doing a good job of identifying critical congenital heart disease, those living in poor or rural communities are less likely to find out their baby has heart disease before birth than those in more affluent or urban communities, according to research to be presented Monday, ...
Bullying leads to depression and suicidal thoughts in teens
2015-04-27
High school students subjected to bullying and other forms of harassment are more likely to report being seriously depressed, consider suicide and carry weapons to school, according to findings from a trio of studies reported at the Pediatric Academic Societies meeting in San Diego.
"Teens can be the victim of face-to-face bullying in school, electronic bullying outside of the classroom and dating violence," said Andrew Adesman, MD, senior investigator of all three studies. "Each of these experiences are associated with a range of serious adverse consequences."
All ...
Bats use both sides of brain to listen -- just like humans
2015-04-27
WASHINGTON -- Researchers from Georgetown University Medical Center and American University have shown that, like humans, mustached bats use the left and right sides of their brains to process different aspects of sounds. Aside from humans, no other animal that has been studied, not even monkeys or apes, has proved to use such hemispheric specialization for sound processing -- meaning that the left brain is better at processing fast sounds, and the right processing slow ones.
The scientists say their study, published in Frontiers of Neuroscience, opens a pathway to ...
New tool to evaluate next-generation tobacco and nicotine products
2015-04-27
A new smoking-specific survey has been developed that is much better than a currently available general health questionnaire at discriminating between different types of 'otherwise healthy' smokers. This test could be useful in determining the potential health impact of next generation tobacco and nicotine products on smokers who switch.
Health-related quality of life (HRQoL) is a measure of the day-to-day functioning and well-being of a person that is used to assess the effect of illness or injury over time. HRQoL measurements are important to public policy, because ...
Health insurance coverage among cancer patients varies greatly by demographics and cancer type
2015-04-27
A new analysis has found that, among patients with cancer, rates of health insurance coverage vary by patient demographics and by cancer type. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that the expansion of coverage through the Affordable Care Act may disproportionally benefit certain patient populations.
In the United States, an estimated 48 million individuals live without health insurance. To examine how insurance coverage differs among cancer patients according to various individual factors such ...
New Zealand stoats provide an ark for genetic diversity
2015-04-27
British stoats suffered a dramatic loss in genetic diversity in the 20th Century but extinct British genes were preserved in the stoat population of New Zealand, a new study has found.
The research reveals that stoats, which were introduced to New Zealand, have greater genetic diversity there, than in their native Britain. The results are unusual because introducing a species to a new area is usually associated with a loss in its genetic diversity.
The study, which was carried out by researchers at the Universities of Exeter, Auckland, Griffith and Canberra and at Landcare ...
Ambiguous situations make it easier to justify ethical transgressions
2015-04-27
To maintain the idea that we are moral people, we tend to lie or cheat only to the extent that we can justify our transgressions. New research suggests that situational ambiguity is one such avenue for justification that helps us preserve our sparkling self-image. Findings from two related experiments show that people are apt to cheat on a task in favor of their self-interest but only when the situation is ambiguous enough to provide moral cover.
The research, conducted by psychological scientists Andrea Pittarello, Margarita Leib, Tom Gordon-Hecker, and Shaul Shalvi, ...
Common back problems may be caused by evolution of human locomotion
2015-04-27
A common spinal disease could be the result of some people's vertebrae, the bones that make up the spine, sharing similarities in shape to a non-human primate. The research, published in the open access journal BMC Evolutionary Biology, suggests that the relatively quick evolution of the ability to walk on two legs may have had a substantial impact on modern human health.
Humans are more commonly afflicted with spinal disease than non-human primates, and one widely discussed explanation for this is the stress placed on the spine by bipedal locomotion. This research backs ...
Could smell hold the key to ending pesticide use?
2015-04-27
UK scientists may have uncovered a natural way of avoiding the use of pesticides and help save plants from attack by recreating a natural insect repellent.
Scientists from Cardiff University and Rothamsted Research have, for the first time, created tiny molecules which mirror a natural occurring smell known to repel insects.
The scientists were able to make similar smelling insect repellent molecules, by providing the enzyme, ((S)-germacrene D synthase), which creates the smell, with alternative substrate molecules.
The effectiveness of the smell or perfume to ...
LAST 30 PRESS RELEASES:
Thirty-year mystery of dissonance in the “ringing” of black holes explained
Less intensive works best for agricultural soil
Arctic rivers project receives “national champion” designation from frontiers foundation
Computational biology paves the way for new ALS tests
Study offers new hope for babies born with opioid withdrawal syndrome
UT, Volkswagen Group of America celebrate research partnership
New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll
Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes
University of Cincinnati Cancer Center presents research at AACR 2025
Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025
AACR: Researchers share promising results from MD Anderson clinical trials
New research explains why our waistlines expand in middle age
Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker
Chips off the old block
Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia
Cutting the complexity from digital carpentry
Lung immune cell type “quietly” controls inflammation in COVID-19
Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity
State and sociodemographic trends in US cigarette smoking with future projections
Young adults drive historic decline in smoking
NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research
Chimpanzee stem cells offer new insights into early embryonic development
This injected protein-like polymer helps tissues heal after a heart attack
FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology
In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity
Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects
A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions
AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate
Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative
Structure dictates effectiveness, safety in nanomedicine
[Press-News.org] Preliminary safety findings: IFN-free DAA combination in chronic HCV patientsSafety findings from the ongoing RUBY-1 study evaluating ombitasvir / paritaprevir / ritonavir in combination with dasabuvir (3D) in chronic hepatitis C virus (HCV) genotype 1 (GT1) patients with severe renal impairment or end-stage renal disease