Partial sleep deprivation linked to biological aging in older adults
Findings causally link sleep deprivation to the etiology of biological aging
2015-06-10
(Press-News.org) DARIEN, IL - A new study suggests that one night of partial sleep deprivation promotes biological aging in older adults.
Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence. These findings causally link sleep deprivation to the etiology of biological aging, and further supports the hypothesis that sleep deprivation may be associated with elevated disease risk because it promotes molecular processes involved in biological aging.
"Our data support the hypothesis that one night of not getting enough sleep in older adults activates important biological pathways that promote biological aging," said lead author Judith Carroll, PhD, assistant professor of psychiatry and biobehavioral science at the UCLA Cousins Center for Psychoneuroimmunology in Los Angeles, Calif.
The research abstract was published recently in an online supplement of the journal Sleep and will be presented Wednesday, June 10, in Seattle, Washington, at SLEEP 2015, the 29th annual meeting of the Associated Professional Sleep Societies LLC.
The study group comprised 29 community-dwelling older adults. They were age 61-86 years and 48 percent were male. Participants underwent an experimental partial sleep deprivation protocol over four nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (restricted 3 a.m. - 7 a.m.) and another uninterrupted night of sleep (recovery). Blood samples were obtained each morning to assess PBMC gene expression using Illumina HT-12 arrays.
INFORMATION:
This study was supported with funding by the UCLA Cousins Center for Psychoneuroimmunology, UCLA, American Sleep Medicine Foundation and the National Institute on Aging (NIA).
Abstract Title: Partial Sleep Deprivation Induces DNA Damage and Senescence in Older Adults
Abstract ID: 0082
Presentation Date: Wednesday, June 10
Presentation Type: Oral Presentation
Presentation Time: 2:00 p.m. to 2:15 p.m.
The SLEEP 2015 abstract supplement is available at http://journalsleep.org/ViewAbstractSupplement.aspx.
For a copy of the abstract or to arrange an interview with the study author or an AASM spokesperson, please contact AASM Communications Coordinator Lynn Celmer at 630-737-9700, ext. 9364, or lcelmer@aasmnet.org.
About SLEEP 2015
More than 5,000 sleep medicine physicians and sleep scientists will gather at SLEEP 2015, the 29th annual meeting of the Associated Professional Sleep Societies LLC (APSS), which will be held June 6-10 at the Washington State Convention Center in Seattle. The scientific program will include about 1,200 research abstract presentations. The APSS is a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society (http://www.sleepmeeting.org).
About the American Academy of Sleep Medicine
Established in 1975, the American Academy of Sleep Medicine (AASM) improves sleep health and promotes high quality patient centered care through advocacy, education, strategic research, and practice standards. With nearly 10,000 members, the AASM is the largest professional membership society for physicians, scientists and other health care providers dedicated to sleep medicine (http://www.aasmnet.org).
ELSE PRESS RELEASES FROM THIS DATE:
2015-06-10
As it turns out, people who speak their minds loudly and often could be responsible for economic prosperity.
That's according to a new study by Michigan State University economist Siddharth Chandra, director of MSU's Asian Studies Center, and Nita Rudra, associate professor in the Department of Government at Georgetown University.
"Our study demonstrates that freedom to express our opinions is not just something we should enjoy," said Chandra, who's also a professor in MSU's James Madison College. "It could have very important consequences - sometimes preventing the ...
2015-06-10
DARIEN, IL - A new study suggests that pre-diagnostic short sleep duration and frequent snoring were associated with significantly poorer cancer-specific survival, particularly among women with breast cancer.
Results show that stratified by cancer site, short sleep duration and frequent snoring were associated with significantly poorer breast cancer-specific survival.
"Our results suggest that sleep duration is important for breast cancer survival, particularly in women who snore," said lead author Amanda Phipps, assistant professor of epidemiology at the University ...
2015-06-10
From AGU's blogs: New Tool Could Track Space Weather 24 Hours Before Reaching Earth
A new model, described in a June 9 paper in the journal Space Weather, might finally give scientists a tool to predict a coronal mass ejection's magnetic configuration from afar, which means forecasters could give utility grid and satellite operators a full 24-hour advance warning to protect their systems.
From AGU's journals: Satellite Measurements May Help Real-Time Water Management
With the demand for water stored in reservoirs rising in many areas, it is becoming increasingly ...
2015-06-10
This news release is available in French. Montreal, June 10, 2015 -- When you're one and a half years old, having your favourite ball taken away is likely to result in a temper tantrum. But while babies wear their feelings on the sleeves of their onesies, adults often mask their emotions, responding to life's disappointments with stoic reserve.
While you might think that witnessing such reactions would confuse toddlers and lead them to believe emotionally reserved adults aren't being honest -- so by extension are untrustworthy to begin with -- new research shows ...
2015-06-10
As little as two minutes of high-intensity exercise four times a day improves health outcomes in adolescents, but the same amount of moderate-intensity exercise does not reap the same rewards, according to a new study from the University of Exeter.
Researchers found that when exercise is broken up into short bursts over the course of a day - replicating the way young children go about being active - only high-intensity exercise is effective in improving blood sugar levels, fat metabolism and blood pressure in adolescents after the consumption of a fatty meal.
The ...
2015-06-10
New research suggests pedophiles are more likely to have superficial facial flaws, known as Minor Physical Anomalies (MPAs). They are also more likely to be left-handed, says Fiona Dyshniku of the University of Windsor in Canada. She led an investigation into the prevalence and distribution of physical anomalies among men who are sent for sexological assessment. The study in Springer's journal Archives of Sexual Behavior adds to a growing body of evidence that suggests pedophilia develops prenatally, around the same time that such physical flaws develop.
"Evidence is ...
2015-06-10
New research using high-speed gambling experiments shows that, for most of us, the last experience we've had can be the defining one when it comes to taking a decision, coming at the expense of other experiences we've accumulated further back in time.
The study, published today in the journal Proceedings of the Royal Society B, supports the idea that the 'banker's fallacy' - focusing on immediate growth at the expense of longer-term stability that would produce better results - is intuitive in the way many of us make quick decisions.
People's natural inclination towards ...
2015-06-10
Advances in stem cell transplantation and gene therapy have been pioneered in vision research. An international team of researchers from Bristol, Toronto, Pittsburgh, Dallas and Montreal have identified a gene that could be responsible for some cases of human night blindness.
Leber's congenital amaurosis (LCA) is a group of hereditary retinal diseases that result in severe loss of vision in early childhood and is estimated to affect around 1 in 80,000 of the population. Recent clinical trials of gene therapy for LCA have shown early promising results in treated patients ...
2015-06-10
This news release is available in French. In an article published in the journal Environment International, researchers from Inserm (Inserm Unit 1085 - IRSET, the Institute of Research in Environmental and Occupational Health, Rennes), in association with the Laboratory for Developmental and Educational Psychology, LPDE (Rennes 2 University), provide new evidence of neurotoxicity in humans from pyrethroid insecticides, which are found in a wide variety of products and uses. An increase in the urinary levels of two pyrethroid metabolites (3-PBA and cis-DBCA) in children ...
2015-06-10
ANN ARBOR, Mich. - It started out as a treatment for arthritis. But steered by science, it could become a first new approach in two decades for treating the damage that diabetes inflicts on the kidneys of millions of people.
This past weekend, University of Michigan Medical School researchers and their colleagues presented promising results from a clinical trial of the experimental drug baricitinib in people with diabetic kidney disease. In a randomized, controlled Phase II study, it reduced a key sign of kidney damage, with higher doses producing the largest effect, ...
LAST 30 PRESS RELEASES:
[Press-News.org] Partial sleep deprivation linked to biological aging in older adults
Findings causally link sleep deprivation to the etiology of biological aging
