PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Patients with lowest BMI have shortest survival in pooled analysis of bev in mCRC

ESMO 17th World Congress on Gastrointestinal Cancer

2015-07-01
(Press-News.org) BARCELONA-LUGANO, 1 July 2015 - Patients with the lowest body mass index (BMI) had the shortest overall survival in an analysis of bevacizumab studies in metastatic colorectal cancer (mCRC) presented for the first time today at the ESMO 17th World Congress on Gastrointestinal Cancer 2015 in Barcelona.(1)

"There is good evidence that obesity increases the risk of getting colorectal cancer and that it increases the risk of colorectal cancer recurrence after curative therapy," said lead study author Dr Yousuf Zafar, associate professor of medicine at Duke Cancer Institute in Durham, North Carolina. "What we did not know prior to these results is whether there is a relationship between obesity and survival in patients with metastatic colorectal cancer."

He continued: "There is evidence that, at least in the US, obese patients may be at risk to receive lower doses of chemotherapy, so we hypothesised that obesity would be associated with worse survival in patients with colorectal cancer."

The current study analysed overall survival and progression-free survival according to four categories of BMI ( END


ELSE PRESS RELEASES FROM THIS DATE:

Thin colorectal cancer patients have shorter survival than obese patients

Thin colorectal cancer patients have shorter survival than obese patients
2015-07-01
DURHAM, N.C. - Although being overweight with a high body-mass index (BMI) has long been associated with a higher risk for colorectal cancer, thinner patients might not fare as well after treatment for advanced cancer, according to a new study from Duke Medicine. The study, which was presented today at the European Society for Medical Oncology World Congress on Gastrointestinal Cancer, found that patients with a low to healthy body weight lived an average of two-and-a-half months less than overweight and obese patients. The results surprised researchers, who expected ...

Deuterium substitution improves therapeutic and metabolic profiles of medicines

2015-07-01
Lexington, Mass., July 1, 2015 - Substituting deuterium for certain hydrogen atoms in molecules has been shown to enhance the metabolic properties of a number of drugs and provides a promising approach to the discovery and development of innovative drug products. The deuterium chemistry approach has the potential to reduce the high failure rates of conventional drug development by building on the known pharmacology of existing compounds and leveraging their desirable therapeutic properties. Selective deuterium substitution as a means of ameliorating unwanted clinically ...

Experimental drug combined with standard chemo may shrink ovarian cancers

2015-07-01
Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells' resistance to paclitaxel. Scientists elsewhere are already testing fostamatinib in people with lymphoma and idiopathic thrombocytopenia purpura, an autoimmune disorder. Based on results of the current study described in a report online June 18 in the journal Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel-fostamatinib ...

Producing spin-entangled electrons

2015-07-01
A team from the RIKEN Center for Emergent Matter Science, along with collaborators from several Japanese institutions, have successfully produced pairs of spin-entangled electrons and demonstrated, for the first time, that these electrons remain entangled even when they are separated from one another on a chip. This research could contribute to the creation of futuristic quantum networks operating using quantum teleportation, which could allow information contained in quantum bits--qubits--to be shared between many elements on chip, a key requirement to scale up the power ...

Warts and all: How St. John's Wort can make you sick

2015-07-01
St John's Wort can produce the same adverse reactions as antidepressants, and serious side effects can occur when the two are taken together, according to new University of Adelaide research. In a study published this month in the journal, Clinical and Experimental Pharmacology and Physiology, researchers compared the pattern of spontaneous reported adverse drug reactions to St John's Wort, a herbal treatment for depression, and fluoxetine, a commonly prescribed antidepressant. They found the adverse reactions were the same for people who took St John's Wort as it was ...

Europe, Siberia and in between: Caucasian populations of non-biting midges

Europe, Siberia and in between: Caucasian populations of non-biting midges
2015-07-01
A research in the North Caucasus, conducted by a group of Russian scientists over three years, has revealed an intermediate distribution of Caucasian populations of non-biting midges between Europe and Siberia. Their observations also proved some interesting morphological distinctions between the studied populations and the previously researched ones from Europe and Siberia. Their results have been published in the open-access journal Comparative Cytogenetics. The study on karyotypical and morphological peculiarities of Ch. bernensis is a part of the investigation of ...

Improving insulation materials, down to wetting crossed fibers

2015-07-01
Sandcastles are a prime example of how adding a small amount of liquid to a granular material changes its characteristics. But understanding the effect of a liquid wetting randomly oriented fibres in a fibrous medium remains a mystery. Relevant to the building industry, which uses glass wool, for instance, this phenomenon can be better understood by studying the behaviour of a liquid trapped between two parallel fibres. It can either remain in the shape of a drop or spread between the fibres into a long and thin column of liquid. Now, scientists have demonstrated that the ...

The bizarre mating habits of flatworms

The bizarre mating habits of flatworms
2015-07-01
Failing to find a mating partner is a dent to the reproductive prospects of any animal, but in the flatworm species Macrostomum hystrix it might involve a real headache. Zoologists from the Universities of Basel and Bielefeld have discovered the extraordinary lengths to which this animal is willing to go in order to reproduce - including apparently injecting sperm directly into their own heads. The academic journal Proceedings of the Royal Society B has published their findings. The absence of a mate usually spells disaster for sexually reproducing animals. However, some ...

Clues to inner atomic life from subtle light-emission shifts

2015-07-01
Atoms absorb and emit light of various wavelengths. Physicists have long known that there are some tiny changes, or shifts, in the light that gets absorbed or emitted, due to the properties of the atomic nucleus. Now, a team of scientists has elucidated the so-called hyperfine structure of cadmium atoms. Relying on a method called laser spectroscopy, they have measured variations in the energy transition within cadmium atom - Cd in the periodic table. They studied a chain of isotopes with an odd number of neutrons ranging from 59 in 107Cd to 75 in 123Cd. From these high-precision ...

Sleep deprivation could reduce intrusive memories of traumatic scenes

2015-07-01
A good night's sleep has long been recommended to those who have experienced a traumatic event. But an Oxford University-led study provides preliminary experimental work suggesting it could actually be the wrong thing to do. The research, conducted in Oxford's Wellcome Trust-funded Sleep and Circadian Neuroscience Institute (SCNi) and published in the journal Sleep, showed that sleep deprivation might prevent people from consolidating memories of experimental trauma (emotional film clips in the study), reducing their tendency to experience flashbacks. Dr Kate Porcheret, ...

LAST 30 PRESS RELEASES:

Printed skin to replace animal testing

Precision medicine could be possible in the fight against antibiotic resistance

Researchers at the Lewis Katz School of Medicine at Temple University identify new targeted approach to protect neurons against degeneration

Western diet causes inflammation, traditional African food protects

Electrochemical method supports nitrogen circular economy

How researchers are shining a light on kidney disease

Some gut bacteria could make certain drugs less effective

PEPITEM sequence shows effects in psoriasis, comparable to steroid cream

Older teens who start vaping post-high school risk rapid progress to frequent use

Corpse flowers are threatened by spotty recordkeeping

Riding the AI wave toward rapid, precise ocean simulations

Are lifetimes of big appliances really shrinking?

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

[Press-News.org] Patients with lowest BMI have shortest survival in pooled analysis of bev in mCRC
ESMO 17th World Congress on Gastrointestinal Cancer