PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Racial disparities in pain children of children with appendicitis in EDs

2015-09-14
(Press-News.org) Black children were less likely to receive any pain medication for moderate pain and less likely to receive opioids for severe pain than white children in a study of racial disparities in the pain management of children with appendicitis in emergency departments, according to an article published online by JAMA Pediatrics.

Racial and ethnic differences in the emergency department (ED) management of pain have been described, with lower rates of opioid prescription for black and Hispanic patients than for white patients. However, there are fewer studies in children. Appendicitis is the most common surgical cause of abdominal pain in the ED and the use of analgesia to patients with appendicitis is encouraged.

Monika K. Goyal, M.D., M.S.C.E., of the Children's National Health System, Washington, and coauthors suggest that examining pain management among children diagnosed with appendicitis provides a more appropriate example in which to evaluate racial differences in the administration of analgesia.

The authors used data from the National Hospital Ambulatory Medical Care Survey from 2003 to 2010 to analyze both the administration of opioid and nonopioid analgesia.

Of an estimated almost 1 million children evaluated in EDs who were diagnosed with appendicitis, 56.8 percent of patients received any analgesia and 41.3 percent received any opioid analgesia, according to the results.

When analyzed by pain score and adjusted for ethnicity, black patients with moderate pain were less likely to receive any analgesia than white patients. Among those patients with severe pain, black patients were less likely to receive opioids than white patients.

While there was no significant difference in overall analgesia administration by race when multiple variables were accounted for, there was a difference in opioid administration by race: black children with appendicitis were less likely to receive opioid analgesia than white children (12.2 percent vs. 33.9 percent.)

Study limitations noted by the authors include patients possibly declining analgesia despite pain and the authors not being able to account for any analgesia patients may have received prior to arriving at the ED.

"Our findings suggest that there are racial disparities in opioid administration to children with appendicitis, even after adjustment for potential confounders. More research is needed to understand why such disparities exist. This could help inform the design of interventions to address and eliminate these disparities and to improve pain management for all youths," the study concludes. (JAMA Pediatr. Published online September 14, 2015. doi:10.1001/jamapediatrics.2015.1915. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: This study was supported by a grant from the National Institutes of Health. Please see article for additional information, including other authors, author contributions and affiliations, etc.

Editorial: Pain and Prejudice

In a related editorial, Eric W. Fleegler, M.D., M.P.H., and Neil L. Schechter, M.D., of Boston Children's Hospital and Harvard Medical School, Boston, write: "How do we explain the persistence of these disparities in treatment? ... If there is no physiological explanation for differing treatment of the same phenomena, we are left with the notion that subtle biases, implicit and explicit, conscious and unconscious, influence the clinician's judgment. ... It is clear that despite broad recognition that controlling pain is a cornerstone of compassionate care, significant disparities remain in our approach to pain management among different populations. Strategies and available knowledge exist to remedy this unfortunate situation; we can and should do better." (JAMA Pediatr. Published online September 14, 2015. doi:10.1001/jamapediatrics.2015.2284. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see article for additional information, including other authors, author contributions and affiliations, etc.

INFORMATION:

Media Advisory: To contact corresponding author Monika K. Goyal, M.D., M.S.C.E., call Emily Hartman at 301-244-6728 or email ehartman@childrensnational.org. To contact corresponding editorial author Neil L. Schechter, M.D., call Erin C. Tornatore at 617-919-3113 or email Erin.Tornatore@childrens.harvard.edu

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

10K genomes project explores contribution of rare variants to human disease and risk factors

2015-09-14
The largest population genome sequencing effort to date is published today in Nature. A series of papers describing resources and application of the data is published at the same time in Nature, Nature Genetics, Bioinformatics and Nature Communications. Rare genetic variants are changes in DNA that are carried only by relatively few people in a population. The UK10K study was designed to explore the contribution of these rare genetic variants to human disease and its risk factors. "The project has made important new contributions towards describing the role of rare ...

PharmaMar shows new data for YONDELIS and PM1183 in soft tissue sarcoma and solid tumors at ECC 2015

PharmaMar shows new data for YONDELIS and PM1183 in soft tissue sarcoma and solid tumors at ECC 2015
2015-09-14
This news release is available in Spanish. Final OS and subgroup analysis of the pivotal study SAR-3007 First interim results of the Y-IMAGE prospective study showing real-world data for trabectedin in advanced soft tissue sarcoma (STS) Clinical data of trabectedin in translocated-related sarcomas, and in advanced leiomyosarcomas and liposarcomas Early clinical studies of PM1183 in combination with paclitaxel or cisplatin show a synergistic activity Madrid, September 14, 2015: PharmaMar announces that it will show new data from clinical pivotal ...

Modulation of brain cholesterol: A new line of research in Alzheimer's disease treatment?

2015-09-14
This news release is available in French. We have known for some years that Alzheimer's disease is characterised by two types of lesions, amyloid plaques and degenerated tau protein. Cholesterol plays an important role in the physiopathology of this disease. Two French research teams (Inserm/CEA/University of Lille/University of Paris-Sud ) have just shown, in a rodent model, that overexpressing an enzyme that can eliminate excess cholesterol from the brain may have a beneficial action on the tau component of the disease, and completely correct it. This is the first ...

The chemistry of addiction (video)

The chemistry of addiction (video)
2015-09-14
WASHINGTON, Sept. 14, 2015 -- It's a condition that turns the lives of millions of Americans upside-down: addiction. Whether it's alcohol, drugs, food or gambling, it can ruin lives. In support of National Recovery Month, which calls attention to substance abuse issues and treatment services, Reactions takes a look at the chemistry behind addiction. Check it out here: https://youtu.be/C6I3CHhBGeQ. Subscribe to the series at http://bit.ly/ACSReactions, and follow us on Twitter @ACSreactions to be the first to see our latest videos. INFORMATION:The American Chemical ...

Protected areas save mangroves, reduce carbon emissions

2015-09-14
DURHAM, N.C. -- Protected areas not only keep significant swaths of Indonesia's shrinking mangrove habitats intact, but also prevent emissions of carbon dioxide that would have been released had these mangroves been cleared, according to a study in the journal Ecological Economics. Published online, the analysis examined the success of protected areas between 2000 and 2010, finding that their use has avoided the loss of 14,000 hectares of mangrove habitat. "This is not a small number," said Daniela Miteva, a postdoctoral researcher at The Nature Conservancy and a Duke ...

It's time to stop thinking in terms of food versus fuel

Its time to stop thinking in terms of food versus fuel
2015-09-14
Whether you have taken a side or a backseat in the discussion, the "food versus fuel" debate affects us all. Some say growing more biofuel crops today will decrease greenhouse gas emissions, but will make it harder to produce food tomorrow, which has prevented the U.S. from maximizing the potential of environmentally beneficial biofuels. In a recent article, published by the National Academy of Engineering, University of Illinois' Gutgsell Endowed Chair of Plant Biology and Crop Sciences Steve Long and University of California's Philomathia Professor of Alternative Energy ...

Tall and slim: They go together, genetic study shows

2015-09-14
University of Queensland scientists have found a genetic basis for height and body mass differences between European populations. Queensland Brain Institute researcher Dr Matthew Robinson said the findings could explain why people from northern European countries tended on average to be taller and slimmer than other Europeans. He said the genes that resulted in greater height correlated strongly with genes that reduced body mass index. "Our findings give a genetic basis to the stereotype of Scandinavians as being tall and lean," Dr Robinson said. The study paves ...

Findings could shed light on cancer, aging

2015-09-14
Researchers at the Johns Hopkins University have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging. In a paper recently published as the cover story in the online journal eLife, biologist David C. Zappulla and graduate student Evan P. Hass show how in baker's yeast cells, two proteins work together to usher a key enzyme to the chromosome tip, the telomere, to restore its length, which diminishes with each round of cell division. That ...

Size matters -- the more DNA the better

2015-09-14
A new study from researchers at Uppsala University shows that variation in genome size may be much more important than previously believed. It is clear that, at least sometimes, a large genome is a good genome. 'Our study shows that females with larger genome lay more eggs and males with larger genome fertilize more eggs', says research leader Göran Arnqvist, Professor of Animal Ecology at Uppsala University. The study of seed beetles is published in the scientific journal Proceedings of the Royal Society of London. The amount of nuclear DNA per cell, or the ...

AHA's 'Life's Simple 7' and diabetes care program reduce risk of heart failure

2015-09-14
Philadelphia, PA, September 14, 2015 - One in four middle-aged adults who survive to age 85 will develop heart failure, according to current estimates. Intervention programs to improve lifestyles are widely advocated, but do they actually work? Investigators in the U.S. and Taiwan independently examined programs that may reduce cardiovascular risk and concluded that both programs will reduce lifetime risk of heart failure. Results are reported in The American Journal of Medicine. A group of American investigators estimated whether greater adherence to the American Heart ...

LAST 30 PRESS RELEASES:

Far-field superresolution imaging via k-space superoscillation

10 Years, 70% shift: Wastewater upgrades quietly transform river microbiomes

Why does chronic back pain make everyday sounds feel harsher? Brain imaging study points to a treatable cause

Video messaging effectiveness depends on quality of streaming experience, research shows

Introducing the “bloom” cycle, or why plants are not stupid

The Lancet Oncology: Breast cancer remains the most common cancer among women worldwide, with annual cases expected to reach over 3.5 million by 2050

Improve education and transitional support for autistic people to prevent death by suicide, say experts

GLP-1 drugs like Ozempic could cut risk of major heart complications after heart attack, study finds

Study finds Earth may have twice as many vertebrate species as previously thought

NYU Langone orthopedic surgeons present latest clinical findings and research at AAOS 2026

New journal highlights how artificial intelligence can help solve global environmental crises

Study identifies three diverging global AI pathways shaping the future of technology and governance

Machine learning advances non targeted detection of environmental pollutants

ACP advises all adults 75 or older get a protein subunit RSV vaccine

New study finds earliest evidence of big land predators hunting plant-eaters

Newer groundwater associated with higher risk of Parkinson’s disease

New study identifies growth hormone receptor as possible target to improve lung cancer treatment

Routine helps children adjust to school, but harsh parenting may undo benefits

IEEE honors Pitt’s Fang Peng with medal in power engineering

SwRI and the NPSS Consortium release new version of NPSS® software with improved functionality

Study identifies molecular cause of taste loss after COVID

Accounting for soil saturation enhances atmospheric river flood warnings

The research that got sick veterans treatment

Study finds that on-demand wage access boosts savings and financial engagement for low-wage workers

Antarctica has lost 10 times the size of Greater Los Angeles in ice over 30 years

Scared of spiders? The real horror story is a world without them

New study moves nanomedicine one step closer to better and safer drug delivery

Illinois team tests the costs, benefits of agrivoltaics across the Midwest

Highly stable self-rectifying memristor arrays: Enabling reliable neuromorphic computing via multi-state regulation

Composite superionic electrolytes for pressure-less solid-state batteries achieved by continuously perpendicularly aligned 2D pathways

[Press-News.org] Racial disparities in pain children of children with appendicitis in EDs