PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Pioneering new technique could revolutionise super-resolution imaging systems

2021-01-21
(Press-News.org) Scientists have developed a pioneering new technique that could revolutionise the accuracy, precision and clarity of super-resolution imaging systems.

A team of scientists, led by Dr Christian Soeller from the University of Exeter's Living Systems Institute, which champions interdisciplinary research and is a hub for new high-resolution measurement techniques, has developed a new way to improve the very fine, molecular imaging of biological samples.

The new method builds upon the success of an existing super-resolution imaging technique called DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) - where molecules in a cell are labelled with marker molecules that are attached to single DNA strands.

Matching DNA strands are then also labelled with a florescent chemical compound and introduced in solution - when they bind the marker molecules, it creates a 'blinking effect' that makes imaging possible.

However, DNA-PAINT has a number of drawbacks in its current form, which limit the applicability and performance of the technology when imaging biological cells and tissues.

In response, the research team have developed a new technique, called Repeat DNA-Paint, which is capable of supressing background noise and nonspecific signals, as well as decreasing the time taken for the sampling process.

Crucially, using Repeat DNA-PAINT is straightforward and does not carry any known drawbacks, it is routinely applicable, consolidating the role of DNA-PAINT as one of the most robust and versatile molecular resolution imaging methods.

The study is published in Nature Communications on 21st January 2021 .

Dr Soeller, lead author of the study and who is a biophysicist at the Living Systems Institute said: "We can now see molecular detail with light microscopy in a way that a few years ago seemed out of reach. This allows us to directly see how molecules orchestrate the intricate biological functions that enable life in both health and disease".

The research was enabled by colleagues from physics, biology, medicine, mathematics and chemistry working together across traditional discipline boundaries. Dr Lorenzo Di Michele, co-author from Imperial College London said: "This work is a clear example of how quantitative biophysical techniques and concepts can really improve our ability to study biological systems".

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Seeds transfer their microbes to the next generation

Seeds transfer their microbes to the next generation
2021-01-21
Scientists have been pondering if the microbiome of plants is due to nature or nurture. Research at Stockholm University, published in Environmental Microbiology, showed that oak acorns contain a large diversity of microbes, and that oak seedlings inherit their microbiome from these acorns. "The idea that seeds can be the link between the microbes in the mother tree and its offspring has frequently been discussed, but this is the first time someone proves the transmission route from the seed to the leaves and roots of emerging plants", says Ahmed Abdelfattah, researcher at the Department of Ecology Environment and Plant ...

Turbulence model could help design aircraft capable of handling extreme scenarios

Turbulence model could help design aircraft capable of handling extreme scenarios
2021-01-21
WEST LAFAYETTE, Ind. -- In 2018, passengers onboard a flight to Australia experienced a terrifying 10-second nosedive when a vortex trailing their plane crossed into the wake of another flight. The collision of these vortices, the airline suspected, created violent turbulence that led to a free fall. To help design aircraft that can better maneuver in extreme situations, Purdue University researchers have developed a modeling approach that simulates the entire process of a vortex collision at a reduced computational time. This physics knowledge could then be incorporated into engineering design codes so that the aircraft ...

Hair aging differs by race, ethnicity

2021-01-21
(Boston)--While aging is an unavoidable biological process with many influencing factors that results in visible changes to the hair, there is limited literature examining the characteristics of hair aging across the races. Now a new study describes the unique characteristics of hair aging among different ethnicities that the authors hope will aid in a culturally sensitive approach when making recommendations to prevent hair damage during one's life-time. Among the findings: hair-graying onset varies with race, with the average age for Caucasians being mid-30s, that for Asians being late 30s, and ...

Addiction researchers recount creating virtual recovery meetings during pandemic

2021-01-21
LAWRENCE -- The COVID-19 pandemic has created new perils and challenges for people experiencing substance use disorders and addictive behaviors. Social distancing and isolation can trigger loneliness, anxiety and depression. These circumstances have put some "recreational users" at risk for developing addictions and caused some in recovery from addictions to relapse. At the same time, the pandemic has made it nearly impossible for mutual-help (e.g., AA, NA) recovery groups to gather in person, forcing a scramble to provide remote support through platforms like Zoom. Now, researchers at the Cofrin Logan Center for Addiction Research and ...

Strange colon discovery explains racial disparities in colorectal cancer

Strange colon discovery explains racial disparities in colorectal cancer
2021-01-21
The colons of African-Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer - the cancer that killed beloved "Black Panther" star Chadwick Boseman at only 43. Scientists led by UVA Health's Li Li, MD, PhD; Graham Casey, PhD; and Matt Devall, PhD, of the Center for Public Health Genomics, found that one side of the colon ages biologically faster than the other in both African-Americans and people of European descent. In African-Americans, however, the right side ages significantly faster, explaining why African-Americans are more likely to develop cancerous lesions on the right side and why they are more likely to suffer colorectal cancer at a younger age, ...

Vegan diet significantly remodels metabolism in young children

2021-01-21
The study concludes that vegan diet has a broad effect on children's metabolism. Serum biomarker levels for vitamins A and D, cholesterol forms and essential amino acids were significantly lower in children on vegan diet compared to age-adjusted omnivores. In addition, docosahexaenoic acid is absent from vegan diet. The results were recently published in a high-profile international scientific journal EMBO Molecular Medicine. Vegan diets gain popularity especially among young adults, and through choices of the families vegan diet is becoming more common in young children, too. The motives behind choosing a vegan lifestyle are ecological, ethical and health-related: vegan ...

SHEA releases COVID-19 research agenda identifying gaps in knowledge

2021-01-21
ARLINGTON, Va. (Jan. 21, 2021) -- A new research agenda developed by 40 leading experts in healthcare epidemiology and infectious diseases defines the critical areas of study to inform clinical practice, policy, and prevention strategies for COVID-19 and future pandemics. "COVID-19 Research Agenda for Healthcare Epidemiology," published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, identifies the gaps in the understanding of the epidemiology, transmission, and individual as well as public health consequences of viral diseases that were revealed through some of the worst phases of the ...

New, simplified genetic test effectively screens for hereditary cancers

New, simplified genetic test effectively screens for hereditary cancers
2021-01-21
Philadelphia, January 21, 2021 - Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial, and other cancers. This alternative to complex, multi-step testing workflows can also determine causes of MMR deficiency often missed by current clinical tests. Their results are presented in the Journal of Molecular Diagnostics, published by Elsevier. MMR genes monitor and repair errors that can occur in normal cell replication and recombination. In some inherited and acquired cancers, one or more of the MMR genes are deactivated. "The impact of ...

Embedded counseling services can improve accessibility for students, MU study finds

Embedded counseling services can improve accessibility for students, MU study finds
2021-01-21
COLUMBIA, Mo. - Kerry Karaffa is the first MU Counseling Center psychologist to be embedded specifically within the University of Missouri College of Veterinary Medicine, where he provides tailored counseling services for professional students training to become veterinarians. He is also aware that veterinarians are at increased risk for mental health concerns and suicidality compared to the general public due to the stressful demands of the job. To help universities better serve students dealing with high levels of stress and anxiety, Karaffa conducted a research study in which he developed and distributed a survey to other counselors specifically embedded in veterinary ...

Modified pain management strategy reduces opioid exposure to trauma patients, study shows

Modified pain management strategy reduces opioid exposure to trauma patients, study shows
2021-01-21
A pain management regimen comprised mostly of over-the-counter medication reduced opioid exposure in trauma patients while achieving equal levels of pain control, according to a new study by physician-researchers at The University of Texas Health Science Center at Houston (UTHealth.) Results of the study, which was conducted at the Red Duke Trauma Institute at Memorial Hermann-Texas Medical Center, were published today in the Journal of American College of Surgeons. "The research shows us that seriously injured people with acute pain can effectively be treated with an opioid-minimizing strategy," ...

LAST 30 PRESS RELEASES:

Thirty-year mystery of dissonance in the “ringing” of black holes explained

Less intensive works best for agricultural soil

Arctic rivers project receives “national champion” designation from frontiers foundation

Computational biology paves the way for new ALS tests

Study offers new hope for babies born with opioid withdrawal syndrome

UT, Volkswagen Group of America celebrate research partnership

New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll

Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes

University of Cincinnati Cancer Center presents research at AACR 2025

Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025

AACR: Researchers share promising results from MD Anderson clinical trials

New research explains why our waistlines expand in middle age

Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker

Chips off the old block

Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia

Cutting the complexity from digital carpentry

Lung immune cell type “quietly” controls inflammation in COVID-19

Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity

State and sociodemographic trends in US cigarette smoking with future projections

Young adults drive historic decline in smoking

NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research

Chimpanzee stem cells offer new insights into early embryonic development

This injected protein-like polymer helps tissues heal after a heart attack

FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology

In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity

Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects

A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions

AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate

Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative

Structure dictates effectiveness, safety in nanomedicine

[Press-News.org] Pioneering new technique could revolutionise super-resolution imaging systems