New formulation of existing medicines prove highly effective against drug-resistant fungus
(Press-News.org) CLEVELAND--A team of researchers from Case Western Reserve University has discovered a formulation of existing medicines that can significantly reduce the presence of the fungus Candida auris (C. auris) on skin, controlling its spread and potentially keeping it from forming infections that have a high mortality rate.
By using a proprietary formulation of topical medications terbinafine or clotrimazole, researchers prevented the growth and spread of the fungus on the skin of a host; the findings appear in the most recent issue of the journal Antimicrobial Agents and Chemotherapy.
"It's a very difficult fungus to kill because it is highly resistant and opportunistic--generally taking hold in those whose immune systems are already battling other threats," said Mahmoud Ghannoum, who led the research as director of the Center for Medical Mycology at the Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center. "It's promising that we were able to decolonize--get rid of the fungus from the skin--with a unique formulation of medicines that have already been approved and are available."
The U.S. Centers for Disease Control (CDC) has identified the fungus as a serious threat to public health because of its resistance to treatment by existing drugs. The fungus was first found in Japan in 2009 and has since been detected in India, the United States and other countries. The mortality rate from infection is about 60%, according previously published research.
C. auris infections often occur in hospitals--with the fungus living undetected, even on the skin of recovering patients, as well as clothing, bedding and other surfaces. Many who get infected are immunocompromised, including patients on antibiotics, which can suppress the presence of good bacteria to help fight the fungus.
Identifying the fungus and diagnosing the infections it causes have been difficult. But emerging molecular-testing methods that can definitively detect the organism are becoming more widespread, Ghannoum said.
"Our results could prove to be one leg of the stool in stopping this unique threat," he said. "While there are many types of bacteria resistant to medicines, C. auris stands alone in this respect among fungi--creating significant challenges for treatment or eradication where it's taken hold."
In this study, researchers tested the proprietary formulation of medicines--a novel transdermal mixture of 1% terbinafine or 1% clotrimazole created with an emerging method known as "Advanced Penetration Technology"--on the skin of mice. Researchers are next seeking approval to test the blend of medications on human volunteers.
"As the only fungus that is multidrug resistant, we still have a lot to learn, especially in how widespread C. auris is in our health care settings," said Ghannoum, who is also the Marti D. and Jeffrey S. Davis Family Master Clinician in Cancer Innovation. "We feel encouraged that our findings are a piece of the puzzle in solving this serious health threat worldwide."
Co-authors of the research, "A Novel Transdermal Application for Clearing Skin Colonization by Candida auris," are Thomas McCormick, associate professor in the Department of Dermatology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center (UH); Lisa Long, a research assistant at the CWRU School of Medicine; and Janet L. Herrada, a research assistant at Case Western Reserve and UH.
The study was supported by a grant from the National Institutes of Health and funding from private companies.
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Though the U.S. and South Korea recorded their first official COVID-19 case on the same day, January 20, 2020, there were notable differences in how each country would ultimately address what has become the world's most severe pandemic since 1918.
Yoonjung Lee, Pharm.D., Ph.D., a pharmacy preceptor and pharmaceutical sciences researcher at the Texas Tech University Health Sciences Center (TTUHSC) Jerry H. Hodge School of Pharmacy, said she was surprised at how South Korea effectively managed the pandemic without the business shutdowns and lockdowns that occurred in China, the U.S. and many European countries.
"I am amazed at how the Korean government had prompt and effective public health interventions to not only address COVID-19, but also to address COVID-19-vulnerable ...
Imagine there are arrows that are lethal when fired on your enemies yet harmless if they fall on your friends. It's easy to see how these would be an amazing advantage in warfare, if they were real. However, something just like these arrows does indeed exist, and they are used in warfare ... just on a different scale.
These weapons are called tailocins, and the reality is almost stranger than fiction.
"Tailocins are extremely strong protein nanomachines made by bacteria," explained Vivek Mutalik, a research scientist at Lawrence Berkeley National Laboratory (Berkeley Lab) who studies tailocins and phages, the bacteria-infecting viruses that tailocins appear to be remnants of. "They ...
AI-powered symptom checkers can potentially reduce the number of people going to in-person clinics during the pandemic, but first, researchers say, people need to know they exist.
COVID symptom checkers are digital self-assessment tools that use AI to help users identify their level of COVID-19 risk and assess whether they need to seek urgent care based on their reported symptoms. These tools also aim to provide reassurance to people who are experiencing symptoms that are not COVID-19 related.
Most platforms, like Babylon and Isabel, are public-facing tools, but the University of California, San Francisco (UCSF) has one of the first COVID-19 symptom checkers that is fully integrated with the users' medical ...
Study using electronic health records of 236,379 COVID-19 patients mostly from the USA estimates that one in three COVID-19 survivors (34%) were diagnosed with a neurological or psychiatric condition within six months of infection.
Anxiety (17%) and mood disorders (14%) were the most common. Neurological diagnoses such as stroke and dementia were rarer, but not uncommon in those who had been seriously ill during COVID-19 infection. For example, of those who had been admitted to intensive care, 7% had a stroke and almost 2% were diagnosed with dementia.
These diagnoses were more common in COVID-19 patients than in flu or respiratory tract infection patients ...
Most patients with kidney failure who were undergoing hemodialysis developed a positive antibody response after being vaccinated for COVID-19, but their response was lower than that of individuals without kidney disease.
Washington, DC (April 6, 2021) -- In a recent study, most patients with kidney failure who were undergoing hemodialysis developed a substantial antibody response following the vaccination with the Pfizer-BioNTech vaccine against COVID-19, but it was significantly lower than that of individuals without kidney disease. The findings will appear in an upcoming ...
CHAPEL HILL, NC - A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions.
The results, published in Cell Reports, illuminate an important process in the normal maturation of the brain and point to the possibility that disrupting this process could contribute to multiple human brain diseases.
"We think abnormalities in microRNA-29 activity are likely to be a common theme in neurodevelopmental ...
Chestnut Hill, Mass. (4/6/2021) -- Compact logos can encourage favorable brand evaluations by signaling product safety, according to a new study by researchers at Boston College's Carroll School of Management and Indian Institute of Management Udaipur, who reviewed the opinions of 17,000 consumers and conducted additional experiments with a variety of logos.
The findings reveal that typography -- specifically tracking, or the spacing between letters in a word -- can influence consumers' interpretations of brand logos. Further, the interpretation is influenced by cultural factors, the researchers reported ...
Fossil discoveries often help answer long-standing questions about how our modern world came to be. However, sometimes they only deepen the mystery--as a recent discovery of four new species of ancient insects in British Columbia and Washington state is proving.
The fossil species, recently discovered by paleontologists Bruce Archibald of Simon Fraser University and Vladimir Makarkin of the Russian Academy of Sciences, are from a group of insects known as snakeflies, now shown to have lived in the region some 50 million years ago. The findings, published in Zootaxa, raise more questions about the evolutionary history of the distinctly elongated insects and why they live where they do today.
Snakeflies are slender, predatory insects that are native to the Northern Hemisphere ...
Starting your day by thinking about what kind of leader you want to be can make you more effective at work, a new study finds.
"It's as simple as taking a few moments in the morning while you're drinking your coffee to reflect on who you want to be as a leader," said Remy Jennings, a doctoral student in the University of Florida's Warrington College of Business, who authored the study in the journal Personnel Psychology with UF management professor Klodiana Lanaj.
When study participants took that step, they were more likely to report helping co-workers and providing ...
April 6, 2021, Alexandria, VA - The American Academy of Otolaryngology?Head and Neck Surgery Foundation published the Clinical Practice Guideline: Opioid Prescribing for Analgesia After Common Otolaryngology Operations today in Otolaryngology-Head and Neck Surgery. This specialty-specific guideline provides evidence-based recommendations on postoperative management for pain in common otolaryngologic procedures, with a focus on opioids.
"As otolaryngologist-head and neck surgeons, we can help reduce the risk of opioid use disorder among our patients and their families," said Samantha Anne, MD, MS, Chair of the Guideline Development Group (GDG). "This clinical practice guideline ...
LAST 30 PRESS RELEASES:
[Press-News.org] New formulation of existing medicines prove highly effective against drug-resistant fungus