PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Most mitral regurgitation patients treated with TEER will require surgery if treatment fails

Up to 95% are precluded from mitral repair surgery

2021-05-01
(Press-News.org) Boston, MA (May 1, 2021) - A new study, presented today at the AATS 101st Annual Meeting, and simultaneously published in the Journal of the American College of Cardiology, finds that patients suffering from severe mitral regurgitation should be carefully screened and counselled before undergoing transcatheter edge-to-edge mitral repair (TEER). Data showed that up to 95 percent of patients who needed surgery after failed TEER could not have their valves repaired, and needed mitral valve replacement to resolve the issue. The findings highlight the need to select patients carefully for TEER.

As a less invasive approach, TEER is an attractive alternative treatment to mitral valve surgery, particularly in older patients. However, TEER is not currently recommended for younger patients who benefit more from a surgical repair long-term. This caution is supported by this study of 463 patients which provides the first national data on surgical outcomes when TEER fails. The surgical repair rate after failed TEER was only 4.8 percent overall, and 6.8 percent in degenerative disease.

"The fact that TEER takes surgical repair off the table as an option for patients makes it essential that we have a very clear understanding of which patients will benefit. This finding has important implications for treatment choice in lower-risk patients with degenerative disease." said Dr. Joanna Chikwe, chair of the Department of Cardiac Surgery in the Smidt Heart Institute at Cedars-Sinai and the Irina and George Schaeffer Distinguished Chair in Cardiac Surgery in honor of Alfredo Trento, MD. "These findings should inform patient consent for TEER, design of clinical trials, and clinical performance measures."

Results of additional industry studies and an NIH-funded trial comparing TEER to mitral surgery should be published within the next two years and may result in updated guidelines on the use of TEER to treat degenerative mitral regurgitation.

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Low profile thoracic aortic endograft device reduces complications and expands patient pool

2021-05-01
Boston, MA (May 1, 2021) - Preliminary results of a clinical trial, presented today at the AATS 101st Annual Meeting, showed that a new, low-profile thoracic aortic endograft is safe and effective in the treatment of descending thoracic aortic aneurysm or penetrating atherosclerotic ulcer (PAU) diseases. A multi-disciplinary team, led by both cardiac and vascular surgeons as co-investigators, conducted the study in 36 centers in the United States and Japan, enrolling patients between 2016 and 2019. The trial aimed to measure safety and efficacy of the RELAY®Pro endovascular device, a second-generation product featuring a dramatically reduced profile and a non-bare stent ...

Study finds up to 24 percent of esophagectomy patients can develop VTE post-operatively

2021-05-01
Boston, MA (May 1, 2021) - A new study presented today at the AATS 101st Annual Meeting, found that the percentage of patients undergoing esophagectomy for cancer who suffer Venous Thromboembolism (VTE) post-operatively is much higher than previously reported, with as many as 24 percent suffering from Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE). Six-month mortality for patients with VTE was 17.6 percent compared to 2.1 percent for those without. Venous Thromboembolism (VTE) is a common, potentially preventable post-operative complication leading to significant morbidity and mortality. Esophagectomy patients are amongst the highest risk groups ...

A glimmer of hope: New weapon in the fight against liver diseases

A glimmer of hope: New weapon in the fight against liver diseases
2021-05-01
Niigata, Japan--Researchers from Niigata University , the University of Tokyo, Osaka University and Tokyo Medical University, Japan have developed a new approach that could revolutionize the treatment, prevention, and possibly reversal of the damages caused by liver diseases. This novel strategy exploits small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs). Cirrhosis and other chronic liver diseases remain a global health concern, with close to 2 million deaths reported annually, these account for approximately 3.5% of annual worldwide deaths. All these ...

Three ways to improve scholarly writing to get more citations

2021-05-01
Researchers from University of Arizona and University of Utah published a new paper in the Journal of Marketing that examines why most scholarly research is misinterpreted by the public or never escapes the ivory tower and suggests that such research gets lost in abstract, technical, and passive prose. The study, forthcoming in the Journal of Marketing, is titled "Marketing Ideas: How to Write Research Articles that Readers Understand and Cite" and is authored by Nooshin L. Warren, Matthew Farmer, Tiany Gu, and Caleb Warren. From developing vaccines to nudging people to eat less, scholars conduct research that could change the world, but most of their ideas either are misinterpreted by the public or never escape the ivory tower. Why does most academic ...

Save the mother, save the child

Save the mother, save the child
2021-05-01
Supporting female survivors of childhood maltreatment is critical to disrupting intergenerational abuse as new research from the University of South Australia shows a clear link between parents who have suffered abuse and the likelihood of their children suffering the same fate. The finding amplifies an acute need for far better support for victims of child maltreatment to ensure safer and more nurturing environments for all children. Funded by the NHMRC and the Channel 7 Children's Research Foundation, and published in The Lancet Public Health today, the study found that most child maltreatment is occurring among families caught up in intergenerational cycles of child abuse and neglect - 83 per cent of ...

The Lancet: Study confirms greater risk of poor COVID outcomes in minority ethnic groups in England

2021-05-01
Largest study so far of more than 17 million adults in England confirms that minority ethnic groups had a higher risk of testing positive, hospitalisation, admission to intensive care units (ICU), and death from COVID-19 compared with white groups, even after accounting for other factors known to increase risk like deprivation, occupation, household size and underlying health conditions. Disparities for hospitalisation and death lessened for most minority ethnic groups between pandemic waves 1 (February to September 2020) and wave 2 (September to December 2020), but increased for South Asian groups. To tackle ethnic disparities in COVID-19 risks, the authors call for reducing structural disadvantage and inequality, improving quality of and access to healthcare, and improving uptake ...

Antiviral T cells safe and effective for treating debilitating complication common after stem cell transplants

2021-04-30
HOUSTON ? A Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center found that BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), a painful complication common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The study was published today in the Journal of Clinical Oncology. Infusion of T cells targeting BKV resulted in rapid responses, with 67.7% of patients seeing a complete or partial improvement in symptoms after 14 days. This increased to 81.6% of patients after 28 days post-infusion. No cases of grade ...

Branching worm with dividing internal organs growing in sea sponge

Branching worm with dividing internal organs growing in sea sponge
2021-04-30
The marine worm Ramisyllis multicaudata, which lives within the internal canals of a sponge, is one of only two such species possessing a branching body, with one head and multiple posterior ends. An international research team led by the Universities of Göttingen and Madrid is the first to describe the internal anatomy of this intriguing animal. The researchers discovered that the complex body of this worm spreads extensively in the canals of their host sponges. In addition, they describe the anatomical details and nervous system of its unusual reproductive ...

Large collaboration creates cell atlas of COVID-19 pathology

2021-04-30
Scientists from several hospitals and research centers have shown what happens in individual cells of patients who died of COVID-19. In a study published in Nature, the researchers describe how infected cells from multiple organs exhibited a range of molecular and genomic changes. They also saw signs of multiple, unsuccessful attempts by the lungs to repair themselves in response to respiratory failure, which is the leading cause of death in COVID-19 patients. "You really feel the tragedy of the disease when you see that result," said Aviv Regev, co-senior author of the study and a core institute member at the Broad Institute of MIT and Harvard when the study began. "The lung tries everything at its disposal, and it still can't fix itself. This was a very ...

Neural nets used to rethink material design

Neural nets used to rethink material design
2021-04-30
HOUSTON - (April 30, 2021) - The microscopic structures and properties of materials are intimately linked, and customizing them is a challenge. Rice University engineers are determined to simplify the process through machine learning. To that end, the Rice lab of materials scientist Ming Tang, in collaboration with physicist Fei Zhou at Lawrence Livermore National Laboratory, introduced a technique to predict the evolution of microstructures -- structural features between 10 nanometers and 100 microns -- in materials. Their open-access paper in the Cell Press journal Patterns shows how neural networks ...

LAST 30 PRESS RELEASES:

Checking the quality of materials just got easier with a new AI tool

Does hiding author names make science fairer?

Fatal Attraction: Electric charge connects jumping worm to aerial prey

Rice physicists probe quark‑gluon plasma temperatures, helping paint more detailed picture of big bang

Cellular railroad switches: how brain cells route supplies to build memories

Breast cancer startup founded by WashU Medicine researchers acquired by Lunit

Breakthrough brain implant from NYU Abu Dhabi enables safer, more precise drug delivery

Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model

Chickening out – why some birds fear novelty

Gene Brown, MD, RPh, announced as President of the American Academy of Otolaryngology-Head and Neck Surgery and its Foundation

Study links wind-blown dust from receding Salton Sea to reduced lung function in area children

Multidisciplinary study finds estrogen could aid in therapies for progressive multiple sclerosis

Final day of scientific sessions reveals critical insights for clinical practice at AAO-HNSF Annual Meeting and OTO EXPO

Social adversity and triple-negative breast cancer incidence among black women

Rapid vs standard induction to injectable extended-release buprenorphine

Galvanizing blood vessel cells to expand for organ transplantation

Common hospice medications linked to higher risk of death in people with dementia

SNU researchers develop innovative heating and cooling technology using ‘a single material’ to stay cool in summer and warm in winter without electricity

SNU researchers outline a roadmap for next-generation 2D semiconductor 'gate stack' technology

The fundamental traditional Chinese medicine constitution theory serves as a crucial basis for the development and application of food and medicine homology products

Outfoxed: New research reveals Australia’s rapid red fox invasion

SwRI’s Dr. Chris Thomas named AIAA Associate Fellow

National Collegiate Athletic Association (NCAA) funding for research on academic advising experiences of Division I Black/African American student-athletes at minority serving institutions

Johri developing artificial intelligence literacy among undergraduate engineering and technology students

Boston Children’s receives a $35 million donation to accelerate development of therapeutic options for children with brain disorders through the Rosamund Stone Zander and Hansjoerg Wyss Translational

Quantum crystals offer a blueprint for the future of computing and chemistry

Looking beyond speech recognition to evaluate cochlear implants

Tracking infectious disease spread via commuting pattern data

Underweight children cost the NHS as much per child as children with obesity, Oxford study finds.

Wetland plant-fungus combo cleans up ‘forever chemicals’ in a pilot study

[Press-News.org] Most mitral regurgitation patients treated with TEER will require surgery if treatment fails
Up to 95% are precluded from mitral repair surgery