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Novel biomarker linked to hair loss can determine COVID severity in men

2021-05-06
(Press-News.org) LUGANO, 6 May, 2021- Researchers have discovered a novel biomarker to identify male COVID-19 patients most at risk for ICU admission. The findings presented today at EADV's 2021 Spring Symposium, suggest that men with genetic characteristics (phenotypes) sensitive to the male sex hormone androgen, are more likely to experience severe COVID-19 disease.

Researchers were driven to study the association between the androgen receptor (AR) gene and COVID-19, after observing the disproportionate number of men hospitalised with COVID-19 presenting with androgenetic alopecia (a common form of hair-loss) compared to the expected number in a similar age-matched population (79% vs. 31-53%).

Androgenetic alopecia is known to be controlled by variations in the AR gene, which affects how sensitive the body is to androgens (hormones such as testosterone). In addition, an enzyme implicated in COVID-19 infection (TMPRSS2) is regulated by an androgen response element - meaning that it too may be affected by variations in the AR gene. As the polyglutamine repeat (CAG repeat) region located in the AR gene is associated with both androgen sensitivity and androgenetic alopecia; this research sought to identify the connection between CAG repeat region length and predisposition to increased COVID disease severity.

A prospective study of 65 hospitalised COVID-19 positive men measured the AR CAG repeat length of each man. Researchers found that male covid patients with a CAG repeat below 22 nucleotides (CAG END


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PULLMAN, Wash. -- With state legislatures nationwide preparing for the once-a-decade redrawing of voting districts, a research team has developed a better computational method to help identify improper gerrymandering designed to favor specific candidates or political parties. In an article in the Harvard Data Science Review, the researchers describe the improved mathematical methodology of an open source tool called GerryChain. The tool can help observers detect gerrymandering in a voting district plan by creating a pool, or ensemble, of alternate maps that also meet legal voting criteria. This map ensemble can show ...

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We need to build more EV fast-charging stations, researchers say

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Breathing problems are the second most common symptom of heart attacks

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[Press-News.org] Novel biomarker linked to hair loss can determine COVID severity in men