The role of the gut microbiota in inflammatory skin diseases
2021-05-07
(Press-News.org) LUGANO, 7 May, 2021- Findings presented at today's EADV 2021 Spring Symposium suggest that an imbalance in gut microbiota (dysbiosis), could play a significant role in the progression of inflammatory skin disease, Hidradenitis Suppurativa (HS). HS is a painful, long-term skin condition, with a chronic and relapsing nature that significantly impacts patients' quality of life.
Researchers at Hacettepe University collected faecal samples from 15 patients with HS and 15 age and sex matched healthy individuals and analysed regions of the bacterial 16S rRNA gene to investigate differences in their gut microbiota. Researchers found that the relative abundance of three genera of bacteria (known collectively as Firmicutes), unclassified Clostridiales, unclassified Firmicutes and Fusicatenibacter in HS patients were significantly lower than that in controls (p = 0.005, p = 0.029, and p = 0.046, respectively). Reduced amounts of these bacteria are known to disrupt the regulatory balance within the gut and stimulate an inflammatory response.
The human gastrointestinal tract is inhabited with a wide variety of bacterial organisms, known collectively as the gut microbiome.1 Studies have increasingly demonstrated that the gut microbiome and skin are intrinsically connected, offering defence against pathogens in the environment. This relationship is known as the 'gut-skin axis' and has been linked to many inflammatory and autoimmune skin disorders, such as acne and psoriasis. This connection inspired the researchers to characterise the composition of HS patients' intestinal microbiome, hypothesising that imbalance may play a role in the high inflammatory burden of this condition. HS is a multifactorial disease caused by both genetic and environmental factors. Obesity and smoking can significantly exacerbate symptoms, and both of these have an impact on the gut microbiome.
Dr Neslihan Demirel Ogut, Usak University Training and Research Hospital explains, "Our research provides evidence the gut-skin axis is implicated in the progression of this chronic inflammatory skin disorder. While further evidence is required, our research suggests that dietary alteration and personalised probiotic supplementation might also be beneficial for HS patients, particularly since treatment options are limited for these individuals."
Gut microbiota plays a critical role in human health through development of the immune response, controlled by specific pathways and the products of metabolism, known as short-chain fatty acids (SCFA). Bacteria in the gut (such as Firmicutes) produce these SCFAs that ensure a balance between immune cells that stimulate or suppress an inflammatory response is maintained. Any disruption to this balance, as demonstrated by the reduced abundance of these organisms in the gut microbiome of HS patients, may induce an unwanted inflammatory response.
Additional research is required to further understand and explain the connections between the gut microbiota and excessive inflammatory state in HS patients. "As one of the preliminary studies investigating HS, this pioneering research lays the foundation for future research into the management of this debilitating condition. It is an exciting breakthrough in a topic currently at the forefront of scientific research," says Marie-Aleth Richard, EADV Board Member and Professor at the University Hospital of La Timone, Marseille.
INFORMATION:
Notes to Editors
A reference to the EADV Spring Symposium or EADV Spring Symposium 2021 must be included when communicating any information within this press release.
Contact:
For further information or to arrange an expert interview, please contact:
Lewis Picton - EADV Press Officer
lpicton@saycomms.co.uk
+44 (0) 208 971 6419
Sophie Graham - EADV Press Officer
sgraham@saycomms.co.uk
+44 (0) 208 971 6413
Catriona Martin - EADV Press Officer
cmartin@saycomms.co.uk
+44 (0) 208 971 6412
About Hidradenitis Suppurativa:
Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin condition that typically occurs after puberty.3 The primary clinical presentation is painful inflamed nodules or boils in the apocrine gland-bearing regions (armpits, genital area, groin, breasts and buttocks/anus) that progress to abscesses, sinus tracts and scarring.4 Estimated prevalence is 1-4% worldwide and HS is three times more common in women than men. The presentation of the disease is distinct, yet HS is not well-recognised except in dermatology clinics.
About EADV
Founded in 1987, EADV is a leading European Dermato-Venereology Society with the important aims of improving the quality of patient care, furthering knowledge and education of dermatologists and venereologists globally through innovation, and advocating on behalf of the speciality and patients. EADV collaborates with other organisations to provide a strong and clear voice to influence the European health agenda. It is a non-profit organisation with over 7,000 members across 113 different countries in the world, providing a valuable service for every type of dermato-venereologist professional.
To find out more visit https://www.eadv.org/.
About EADV Spring Symposium 2021:
EADV Spring Symposium - A New Season for Dermatology and Venereology, is one of the most important, CME-CPD accredited all-virtual events in the Dermato-Venereology calendar. The 2-day Scientific Programme is bursting with new findings and scientific breakthroughs, providing a unique opportunity to both hear the latest in Dermato-Venereology and connect with leading experts. To find out more visit https://www.eadvsymposium2021.org/.
References:
1. Silva YP, Bernardi A, Frozza RL. The role of short-chain fatty acids from fut microbiota in gut-brain communication. Front. Endocrinol. 2020 Available from: https://www.frontiersin.org/articles/10.3389/fendo.2020.00025/fullAccessed April 2021
2. Bukin, Y., Galachyants, Y., Morozov, I. et al. The effect of 16S rRNA region choice on bacterial community metabarcoding results. Nature Sci Data. 2019. Available from: https://www.nature.com/articles/sdata20197. Accessed April 2021
3. Dufour DN, Emtestam L, Jemec GB. Hidradenitis suppurativa: a common and burdensome, yet under-recognised, inflammatory skin disease. Postgrad. Med. J. 2014;90:216-221.
4. Kurzen H et al What causes hidradenitis suppurativa? Exp Dermatol. 2008 May;17(5):455-6 Accessed April 2021
ELSE PRESS RELEASES FROM THIS DATE:
2021-05-07
LUGANO, 6 May, 2021- The dermatological impact of COVID-19 is a burning topic at EADV's 2021 Spring Symposium. New research presented today highlights the effect that stringent hand hygiene during the pandemic has had on hand skin health.1
Researchers at Father Muller Medical College, India, analysed transepidermal water loss (TEWL - an essential parameter for measuring skin barrier function) from 582 people (291 healthcare professionals (HCPs) and 291 healthy individuals from the general population). Results indicated that hand dermatitis was now present among 92.6% of HCPs and 68.7% of the general population, despite only ~3% of HCPs and 2.4% of the general public in the study having reported a prior history of hand dermatitis (obtained through medical history ...
2021-05-07
Are penalty shots a soccer player's dream or nightmare? What should be an easy shot can become a mammoth task when the hopes and fears of an entire nation rest on a player's shoulders, leading them to choke under pressure. Understanding the brain activity behind choking is the driving force behind a new study in open-access journal Frontiers in Computer Science. The study is the first to measure brain activity during penalty shots in a soccer pitch environment. It finds that people who choked activated areas of the brain involved in long-term thinking, suggesting that they were overthinking the consequences of missing the shot. ...
2021-05-07
Researchers from University of Southern California, Bocconi University, and Vrije Universitei Amsterdam published a new paper in the Journal of Marketing that explains the six types of judgements consumers make when determining a product's authenticity and how marketers can use this insight to deliver more authentic offerings.
The study, forthcoming in the Journal of Marketing, is titled "The Concept of Authenticity: What it Means to Consumers" and is authored by Joseph Nunes, Andrea Ordanini, and Gaia Giambastiani.
Consumers crave authenticity. Yet marketing itself is typically considered inherently inauthentic. Hence, firms must learn to understand, manage, and excel at rendering authenticity. The critical question is: how? Marketers who wish to deliver authentic consumption experiences ...
2021-05-07
INDIANAPOLIS - As electronic medical records (EMRs) are increasingly used across the United States, the next generation of physicians, nurses, social workers, pharmacists and other clinicians need to acquire new knowledge and competencies related to use of EMRs early in their clinical education. But training is not routinely provided.
A new study presents the functions and application of the novel, scalable Regenstrief teaching electronic medical record (tEMR) platform which contains a unique, large, anonymized patient database enabling health professions students to learn how to use health information technology (HIT) to best manage the ...
2021-05-07
The way that many of us live has created the "perfect storm" for the evolution and transmission of infectious diseases like Covid-19 according to a researcher at the University of East Anglia.
A new editorial published today describes how the world's vast population of people, pets and livestock has created an ideal breeding ground for infectious diseases which are passed between humans and animals.
It shows how we urgently need to control the transmission of pathogens such as SARS-CoV-2 by using vaccination passports, maximising genetic variation in livestock, and reducing how much meat we eat.
Prof Cock Van Oosterhout, from UEA's School of Environmental Sciences, said: "We humans have been living in a non-sustainable way over the past few centuries. We now have a vast population size ...
2021-05-07
LSE-Lancet Commission critically considers the UK's response to the COVID-19 pandemic and sets out a long-term vision for the NHS which re-lays the foundations for a better, fairer health and care service.
The expert authors make seven recommendations spanning workforce, disease prevention and diagnosis, digital health, and better integration of public health and social care, as well as calling for yearly increases in funding for the NHS, social care, and public health of at least 4% in real terms over the next decade.
Failure to take action risks a continued deterioration in service provision, worsening health outcomes ...
2021-05-06
Early on in the COVID-19 pandemic, health officials seized on contact tracing as the most effective way to anticipate the virus's migration from the initial, densely populated hot spots and try to curb its spread. Months later, infections were nonetheless recorded in similar patterns in nearly every region of the country, both urban and rural.
A team of environmental engineers, alerted by the unusual wealth of data published regularly by county health agencies throughout the pandemic, began researching new methods to describe what was happening on the ground in a way that does not require obtaining information on individuals' movements or contacts. ...
2021-05-06
As state and federal authorities decide whether to continue reimbursing for telehealth services that were suddenly adopted last spring in response to the coronavirus pandemic, a new study out of UC San Francisco has found that clinicians in the San Francisco Health Network (SFHN) overwhelmingly support using these services for outpatient primary care and specialty care visits.
The results surprised the research team, which includes a number of clinicians at Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), since they witnessed firsthand the difficulties that many of their colleagues and patients experienced ...
2021-05-06
SAN FRANCISCO, CA--May 6, 2021--In the brain of a person with Alzheimer's disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally. Some types of neurons in certain brain regions are more susceptible, and even among those subtypes--mysteriously--some perish and some do not.
Researchers at Gladstone Institutes have uncovered molecular clues that help explain what makes some neurons more susceptible than others in Alzheimer's disease. In a study published in the journal Nature ...
2021-05-06
A new study from McGill University suggests that some Icelandic killer whales have very high concentrations of PCBs (polychlorinated biphenyls) in their blubber. But it seems that other orcas from the same population have levels of PCBs that are much lower. It mainly depends on what they eat.
PCBs were industrial chemicals banned decades ago, after they were found to affect the health of both humans and wildlife. But because they degrade very slowly after being released in the environment and they still accumulate in the bodies of marine mammals.
After collecting skin and blubber biopsies ...
LAST 30 PRESS RELEASES:
[Press-News.org] The role of the gut microbiota in inflammatory skin diseases
