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New research supports pridopidine's neuroprotective properties in Huntington's Disease models

2021-05-25
(Press-News.org) Newly published papers further elucidate the mechanisms underlying pridopidine's neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidine's therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases

Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, END


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Narcissism linked to aggression in review of 437 studies

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COLUMBUS, Ohio - A comprehensive analysis of 437 studies from around the world provides the best evidence to date that narcissism is an important risk factor for both aggression and violence, researchers said. The link between narcissism and aggression was found for all dimensions of narcissism and for a variety of types of aggression. Results were similar regardless of gender, age, whether they were college students, or country of residence. And, to have an impact, narcissism doesn't have to be at levels so high as to be pathological. Findings showed ...

Nonprofits, federal government surpass pharma to lead Alzheimer's drug development

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Two articles published online today by Alzheimer's & Dementia: Translational Research & Clinical Interventions, a journal of the Alzheimer's Association, show substantial changes in the focus and funding of clinical trials for Alzheimer's disease therapies. The newly published articles throw a greater spotlight on a decision -- now before the U.S. Food and Drug Administration (FDA) -- that would potentially bring a new drug therapy to Alzheimer's patients for the first time in nearly 20 years. Researchers analyzed clinicaltrials.gov, the U.S. National Library of Medicine's database, and five years of annual Alzheimer's pipeline reviews published by UNLV School of Integrated Health Sciences research professor Jeffrey L. Cummings ...

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Press (re)play to remember - How the brain strengthens memories during sleep

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While we sleep, the brain produces particular activation patterns. When two of these patterns - slow oscillations and sleep spindles - gear into each other, previous experiences are reactivated. The stronger the reactivation, the clearer will be our recall of past events, a new study reveals. Scientists have long known that slow oscillations (SOs) and sleep spindles - sudden half-second to two-second bursts of oscillatory brain activity - play an important role in the formation and retention of new memories. But experts in the UK and Germany have discovered that the precise combination of SOs and sleep spindles is vital for opening windows during which ...

Engineering matter at the atomic level

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As devices continue to be built on an increasingly small scale, scientists are looking toward developing ways to engineer materials at the atomic level. In a breakthrough that will contribute to this, published in Nature Communications, researchers from the RIKEN Cluster for Pioneering Research and RIKEN Center for Advanced Photonics, along with collaborators, have developed a way to use a "dry transfer technique"--a technique that uses no solvent--to position optical quality carbon nanotubes in a precise way. Carbon nanotubes are a promising type of materials with potential uses in applications such as light-emitting diodes, ...

Odd angles make for strong spin-spin coupling

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HOUSTON - (May 25, 2021) - Sometimes things are a little out of whack, and it turns out to be exactly what you need. That was the case when orthoferrite crystals turned up at a Rice University laboratory slightly misaligned. Those crystals inadvertently became the basis of a discovery that should resonate with researchers studying spintronics-based quantum technology. Rice physicist Junichiro Kono, alumnus Takuma Makihara and their collaborators found an orthoferrite material, in this case yttrium iron oxide, placed in a high magnetic field showed uniquely tunable, ultrastrong interactions between magnons in the crystal. Orthoferrites ...

Soft X-ray method promises nanocarrier breakthroughs for smart medicine

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Ancient Judeans commonly ate non-kosher fish surrounding the time that such food was prohibited in the Bible, suggests a study published in the peer-reviewed journal Tel Aviv. This finding sheds new light on the origin of Old Testament dietary laws that are still observed by many Jews today. Among these rules is a ban on eating any species of fish which lacks scales or fins. The study reports an analysis of ancient fish bones from 30 archaeological sites in Israel and Sinai which date to the more than 2,000-year span from the Late Bronze Age (1550-1130 ...

ED visits for appendicitis, miscarriage fell sharply in first wave of COVID-19 pandemic

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Emergency department visits for common conditions such as appendicitis, miscarriage, gallbladder attacks and ectopic pregnancy decreased markedly at the start of the COVID-19 pandemic, but patient outcomes were not worse, found research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.202821. "These findings are reassuring, as patients who required emergency care in the first wave of the pandemic continued to present to the emergency department, received similar care and had similar outcomes to patients presenting in the prepandemic period," writes Dr. David Gomez, a trauma surgeon at St. Michael's Hospital, Unity ...

Whale carcasses help answer mysteries of elusive species

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Summary: A new study published by the open access publisher Frontiers shows the usefulness of opportunistically collected specimens, such as stranded carcasses, to study elusive species. The researchers used stable isotope analysis of skin, muscle, and bone tissue of Sowerby's beaked whales to study their spatial ecology. They found that the species exhibits both short- and long-term habitat fidelity. The results are published in Frontiers in Conservation Science and show the importance of such studies for marine wildlife conservation. A mysterious whale species Beaked whales, a species of toothed whales, make up more than 25% of extant cetaceans (dolphins, porpoises, and whales), but are elusive and notoriously difficult to study. They live in deep waters and stay away ...

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[Press-News.org] New research supports pridopidine's neuroprotective properties in Huntington's Disease models