(Press-News.org) [Brooklyn, New York] - [June 21, 2021] - Applied Biological Laboratories (Applied Bio), a biopharmaceutical company focused on the respiratory disease market, announced that its study published online in Immunology, Inflammation and Disease was able to determine the mechanism behind respiratory inflammation and treat it effectively with Biovanta(TM), a 100% naturally derived, over-the-counter (OTC) drug for cold, cough and sore throat.
The study results also showed that almost all of the leading OTC products on the market can damage the upper respiratory cells and may prolong illness. This research study and its findings represent one of the first major breakthroughs in decades for the cold and flu market.
The study, titled "A Novel Anti-inflammatory Treatment for Bradykinin-induced Sore Throat or Pharyngitis," explored the efficacy of common OTC medications. Sore throat, or pharyngitis, is one of the most common symptoms of upper respiratory infection and a leading cause of physician visits and antibiotic prescriptions, but few, if any, OTC medications are proven to address sore throat inflammation. The randomized, blinded, placebo-controlled study utilized state-of-the-art, fully developed human respiratory tissues (organoids) grown from nasal stem cells, stimulated with a molecule called bradykinin (one of the body's first inflammatory signals following an upper respiratory infection). Bradykinin uses Cox enzymes to stimulate more inflammatory molecules, such as prostoglandin. Once the mechanisms behind pharyngitis were understood, the cells were treated with a variety of OTC sore throat medications. Aspirin and a formula containing it as an active ingredient were also investigated as treatments and were found to be much more effective than any OTC treatment. Despite being a well-known Cox inhibitor, aspirin is not widely used for upper respiratory inflammation.
"Furthering our understanding of the mechanism behind respiratory inflammation is a key step in studying the effectiveness of common medications, and this study is profound because it also shows that ingredients commonly used in leading cough, cold and sore throat products like dextromethorphan, acetaminophen, guaifenesin and benzocaine are ineffectual and can even be toxic," said Alan Greene, MD, practicing physician and founder of DrGreene.com. "Alternatively, this study shows that the ingredients in Biovanta offer a safe and effective treatment for inflammation vs. a reduction of the symptoms."
Specific study results include:
Of the 20 OTC products tested, all but one showed inflammatory and damaging effects on at least one of the measures tested, which were: level of prostaglandin E2 (PGE2) or interleukin 8 (IL-8) - key measures of inflammation, damage to the membrane barrier as measured by the electrical resistance across it and microscopy (through a microscope), and the release of lactate dehydrogenase (LDH), a chemical that is released by cells when they die.
Biovanta, an OTC product with low-dose aspirin and other anti-inflammatory ingredients, reduced inflammation when applied to affected cells and tissues, making it the first scientifically proven 100% naturally derived, OTC medicine for treating cough, cold and sore throat.
Aspirin can lower prostaglandin levels, but there is a small therapeutic window in which aspirin is anti-inflammatory when sprayed onto cells: 6 mg per dose. Below this the drug would not have a significant affect and above it, it becomes inflammatory. For comparison, a baby aspirin contains 81 mg.
"This study is a major breakthrough in understanding the underlying mechanism of inflammation in upper respiratory illnesses, which wasn't possible until recent scientific advancements that enabled the creation of organoids for use in testing human tissue reactions," said Nazlie Latefi, PhD, co-founder and chief science officer, Applied Bio. "These scientifically proven results show that our groundbreaking formulas strengthen the respiratory barrier, unlike common OTC products, and we look forward to further demonstrating their effectiveness through a post-market real-world study."
INFORMATION:
About Applied Biological Laboratories
Applied Biological Laboratories (Applied Bio) is a New York-based biopharmaceutical company disrupting the respiratory disease market - its products target underlying biochemical pathways and heal the respiratory system rather than mask symptoms, all with 100% natural bioactive molecules. Biovanta(TM), Applied Bio's first product, is the only 100% natural, over-the-counter (OTC) medicine for cough, cold and sore throat. For more information, please visit http://www.appliedbioinc.com and connect on Facebook, Twitter, and LinkedIn.
UNIVERSITY PARK, Pa. -- Clickbait headlines might not be as enticing to readers as once thought, according to a team of researchers. They added that artificial intelligence -- AI -- may also come up short when it comes to correctly determining whether a headline is clickbait.
In a series of studies, the researchers found that clickbait -- headlines that often rely on linguistic gimmicks to tempt readers to read further -- often did not perform any better and, in some cases, performed worse than traditional headlines.
Because fake news is a concern on social media, researchers have explored using AI to systematically identify and block clickbait. However, the studies also suggest ...
Amazon rain forests could be at far higher risk of extreme drought than previously thought, according to new research.
An international study, led by the University of Leeds, warns that huge areas in the eastern part of the Amazon face severe drying by the end of the century if action is not taken to curb carbon emissions.
As a result, large amounts of carbon dioxide would be released from the forest into the atmosphere,
adding to the greenhouse gas effect and driving further climate change.
The increased dryness during the Amazon dry season would further threaten the viability of large parts of the rainforest, as trees are already water stressed and there is greater risk of forest fires.
The predicted droughts could also have far-reaching consequences ...
Vanadium oxo (VO) species were often used to oxidise sulfide/amine compounds and alkenes when combined with peroxide oxidants. VO species are well known as important vitamin supplements for potential diabetic prevention. They are highly prevalent as metalloenzyme like haloperoxidase. The current catalyst class comprises VO species, substituted-salicylaldehyde, and alpha-amino acids that are nontoxic and highly enriched in ascidian sea animals and plants. Professor Chien-Tien Chen of NTHU pioneered aerobic asymmetric couplings of 2-naphthol with VO species to form optically active binaphols in 2001 (reported in C&EN News, 79(20), 45-57(2001)), which was believed to proceed in a VO-bound, single/dual-mode activation or free radical-radical/free ...
What causes an eruption? Why do some volcanoes erupt regularly, while others remain dormant for thousands of years? A team of geologists and geophysicists, led by the University of Geneva (UNIGE), Switzerland, has reviewed the literature on the internal and external mechanisms that lead to a volcanic eruption. Analyzing the thermo-mechanics of deep volcanic processes and magma propagation to the surface, together with magma chemistry, the geologists determined that most of the magma rising from depth actually does not cause a volcanic eruption. They also show that older volcanoes tend to produce less frequent, but larger and more dangerous eruptions. Their findings, published in Nature Reviews ...
A new study published in Nature Communications demonstrates the important role that planting new commercial forests could play in the fight against climate change by including new accounting of greenhouse gas (GHG) mitigation achieved from future use of harvested wood.
The study applied a novel, time-dependent assessment to capture the complex dynamics of carbon uptake, storage and partial eventual release back to the atmosphere, alongside product and energy substitution by wood products, over a 100-year timeframe.
Uniquely, the study considered multiple wood uses along multi-decadal cascading value chains (e.g. construction timber to paper to bioenergy), and future projections on wider decarbonisation of substituted ...
Although the emissions targets for aviation are in line with the overall goals of the Paris Agreement, there is a high likelihood that the climate impact of aviation will not meet these goals, according to a new study.
Aviation is an important contributor to the global economy, but contributes to climate change by creating carbon dioxide (CO2) as well as non-CO2 effects such as forming nitrogen oxides, ozone and contrailcirrus clouds, which all contribute to global warming.
Researchers believe that, as long as the industry stages a recovery, the restrictions placed on global air travel in response to COVID-19 lockdown will only have ...
Warming seas are driving many species of marine life to shift their geographic ranges out of the tropics to higher latitudes where the water is cooler. Florida's reefs will not be able to make that northward move, however, as they will be caught between intolerably hot tropical waters and increasingly frequent water-cooling cold snaps, according to new findings from Florida Institute of Technology, the U.S. Geological Survey, and several other institutions to be published June 22 in Nature's Scientific Reports.
Populations of the main species of reef-building corals are ...
Published in The Lancet Regional Health - Europe and part-funded by National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, the study identified that people with multiple respiratory conditions were most likely to develop depression and anxiety later on. This has possible implications for future healthcare services if the Covid-19 pandemic brings about increases in long-term respiratory issues. The study confirms the importance of integrating mental health support early into care plans for those with multiple physical health conditions.
This is the first study of ...
6.4% of the European population suffers from depression, according to a study published in The Lancet Public Health. The work was led by researchers from King's College London, the Hospital del Mar Medical Research Institute (IMIM), the Parc de Recerca Sant Joan de Déu-Institut de Recerca Sant Joan de Déu, the Institute of Biomedicine at the University of León (IBIOMED), and the CIBER on Epidemiology and Public Health (CIBERESP). This figure is higher than that estimated by the World Health Organisation (WHO), which calculated the prevalence of this pathology ...
BEER-SHEVA, ISRAEL, June 22, 2021 -- Researchers at Ben-Gurion University of the Negev (BGU) have developed the first methodology to assess symptoms associated with continuous exposure to traumatic stress from rocket attacks and other security threats, which are not currently measured by diagnostic criteria.
Published in the journal END ...
