COVID-19 monoclonal antibody therapy can reduce hospitalizations, healthcare system stress

Researchers are calling for changes to working culture and conditions for junior doctors in the UK after their new research has highlighted a lack of access to clinical and emotional support. The call comes as a University of Birmingham-led team of researchers, including experts from Keele University, University College London, Oxford University Hospitals NHS Foundation Trust, the London School of Hygiene and Tropical Medicine, and the Universities of Leeds and Manchester, carried out a qualitative study using in-depth interviews with 21 NHS junior doctors. All participants, 16 of whom were women ...

**Note this is a special early release from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2021). Please credit the conference if you use this story** New research being presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) held online this year (9-12 July), suggests that one in 10 veterinary workers in the Netherlands carries strains of extended spectrum beta-lactamase (ESBL)-producing bacteria compared to around one in 20 of the general Dutch population. This higher prevalence could not be explained by known risk factors such as antibiotic use or recent travel, and it seems highly likely that occupational contact with animals in the animal healthcare setting may result in shedding and transmission ...

**Note this is a special early release from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2021). Please credit the conference if you use this story* Irish doctors highlight potential complications following buttock augmentation that can result in hospitalisation in a case report being presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) held online this year (9-12 July). Dr Siobhan Quirke and colleagues from the St James Hospital in Dublin detail the case of a 29-year-old woman who was admitted to hospital with sepsis 14 months after a dermal filler injection.* The exact ingredients of fillers vary by brand, but they all work to enlarge the buttocks, ...

A new study to be presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) (9-12 July) and published this week in The Lancet Infectious Diseases shows that, for residents of long-term care homes for adults aged 65 years and over, a single dose of either the Pfizer or Astra Zeneca COVID-19 vaccine offers around 60% protection against infection from SARS-CoV-2. The study is by Dr Madhumita Shrotri and Dr Laura Shallcross, UCL Institute of Health Informatics, University College London, UK, and colleagues. The greatest effects of SARS-CoV-2 have been in residents of long-term care facilities, who represent a small fraction of the general population but account for ...

A new study by Dana-Farber Cancer Institute researchers has given scientists their first look at the genomic landscape of tumors that have grown resistant to drugs targeting the abnormal KRASG12C protein. Their work shows that, far from adopting a common route to becoming resistant, the cells take a strikingly diverse set of avenues, often several at a time. The findings, reported online today in the END ...

A human genetic mechanism hijacked by SARS-CoV-2, the coronavirus behind the COVID-19 pandemic, to help it spread also makes it vulnerable to a new class of drug candidates, a new study finds. Led by researchers at NYU Grossman School of Medicine, a research team showed that coronavirus reproduction in infected human cells requires chemical changes made by the human protein METTL3 to RNA, a key form of genetic material. Additional human proteins involved in the recognition of modified RNA, YTHDF1 and YTHDF3, were also found to be important to the process. Published online in Genes and Development on June 24, the study showed for the first time that ...

Hospitalizations to treat pediatric gun injuries are expensive, and U.S. taxpayers and the poor are bearing the price, according to a new study from the Stanford University School of Medicine. The study, which published online June 23 in PLOS ONE, found that the average cost of an initial hospitalization for a pediatric firearm injury is around $13,000. A total of about $109 million is spent on such hospitalizations in the country each year. The figures do not capture the total costs of rehabilitating young gunshot victims, which can be much higher. Research into the financial, health and social costs of firearm injuries in the United States has focused mostly on adults, said the study's senior author, Stephanie Chao, ...

In a groundbreaking study, a team of UC Davis researchers has discovered a special type of stem cell that can reduce the amount of the virus causing AIDS, boosting the body's antiviral immunity and repairing and restoring the gut's lymphoid follicles damaged by the simian immunodeficiency virus (SIV), the equivalent of the human immunodeficiency virus (HIV) in non-human primates. ...

Adult corals that survive high-intensity environmental stresses, such as bleaching events, can produce offspring that are better suited to survive in new environments. These results from a series of experiments conducted at the Bermuda Institute of Ocean Sciences (BIOS) in 2017 and 2018 are deepening scientists' understanding of how the gradual increase of sea surface temperatures and other environmental disturbances may influence future coral generations. Researchers on the project included BIOS marine ecologists Samantha de Putron and Gretchen Goodbody-Gringley (now with the Central Caribbean Marine Institute), ecophysiologist Hollie Putnam at the University of Rhode Island (URI), and Kevin Wong, then ...

WACO, Texas (June 23, 2021) - When an organization supports its employees who choose to adopt children, the employees, their families, the adopted children and the organization itself experience positive benefits and outcomes, according to new research from Baylor University. The study, "It Takes a Village: How Organizational Support for Adoption Positively Affects Employees and Their Families," is published in the Journal of Occupational and Organizational Psychology. Researchers from Baylor's Hankamer School of Business include Matthew J. Quade, Ph.D., associate professor of management; ...