PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Identified an early neuronal dysfunction in Parkinson's that could help early diagnosis

Identified an early neuronal dysfunction in Parkinson's that could help early diagnosis
2021-07-07
(Press-News.org) Researchers from IDIBELL and the University of Barcelona (UB) have described that neurons derived from Parkinson's patients show impairments in their transmission before neurodegeneration. For this study, it has been used dopaminergic neurons differentiated from patient stem cells as a model.

Parkinson's is a neurodegenerative disease characterized by the death of dopaminergic neurons. This neuronal death leads to a series of motor manifestations characteristic of the disease, such as tremors, rigidity, slowness of movement, or postural instability. In most cases, the cause of the disease is unknown, however, mutations in the LRRK2 gene are responsible for 5% of cases.

Current therapies against Parkinson's are focus on alleviating the symptoms but do not stop its progression. It is thought that early interventions before the appearance of the first symptoms that prevent neuronal death could slow down or even stop the evolution of the disease. However, currently, the diagnosis is based on the appearance of symptoms, when 70% of the neurons have already been lost. A group of researchers from IDIBELL and the University of Barcelona (UB), led by Dr. Antonella Consiglio (group leader at IDIBELL, ICREA Academy researcher, and professor at the Faculty of Medicine and Health Sciences of the UB and IBUB/Institute of Biomedicine of the UB), Dr. Angel Raya (coordinator of the IDIBELL Regenerative Medicine program and ICREA researcher) and Dr. Jordi Soriano (group leader and professor at the UB and the Institute of Complex Systems from the University of Barcelona), with other national and international collaborators, have identified early functional deficiencies, before death, in neurons derived from patients with genetic Parkinson's. According to Dr. Consiglio ", these discoveries open the door to early diagnosis, which would allow us to carry out a premature intervention that would slow down neuronal death, and therefore, would stop the evolution of the disease". In this work, dopaminergic neurons, the most vulnerable in Parkinson's, differentiated from stem cells (iPSC) of healthy individuals and patients with genetic Parkinson's, have been used as a model. Researchers have observed that these dopaminergic neurons are capable of maturing and forming functional neural networks in culture, in both control and Parkinson's disease conditions.

However, in this work published in npj Parkinson's Disease, it is shown that neurons from individuals with Parkinson's are more spontaneously active and present more explosion episodes in which, for example, the entire network is activated at the same time. All this before the neurodegeneration. The researchers believe that this early neuronal dysfunction could be contributing to initiating the cascade of events responsible for the death of dopaminergic neurons, and consequently, Parkinson's disease. Furthermore, this work highlights the extraordinary window of opportunity provided by experimental models based on iPSC in the understanding and presymptomatic evaluation of neurodegenerative diseases.

This work was supported by the European Research Council-ERC, the Spanish Ministry of Economy and Competitiveness, the Carlos III Institute, AGAUR, and the CERCA program of the Generalitat de Catalunya.

INFORMATION:


[Attachments] See images for this press release:
Identified an early neuronal dysfunction in Parkinson's that could help early diagnosis

ELSE PRESS RELEASES FROM THIS DATE:

Changes in Earth's orbit enabled the emergence of complex life

Changes in Earths orbit enabled the emergence of complex life
2021-07-07
Scientists at the University of Southampton have discovered that changes in Earth's orbit may have allowed complex life to emerge and thrive during the most hostile climate episode the planet has ever experienced. The researchers - working with colleagues in the Chinese Academy of Sciences, Curtin University, University of Hong Kong, and the University of Tübingen - studied a succession of rocks laid down when most of Earth's surface was covered in ice during a severe glaciation, dubbed 'Snowball Earth', that lasted over 50 million years. Their findings are published in the journal Nature Communications. "One ...

A universal approach to tailoring soft robots

2021-07-07
By combining two distinct approaches into an integrated workflow, Singapore University of Technology and Design (SUTD) researchers have developed a novel automated process for designing and fabricating customised soft robots. Their method, published in Advanced Materials Technologies, can be applied to other kinds of soft robots--allowing their mechanical properties to be tailored in an accessible manner. Though robots are often depicted as stiff, metallic structures, an emerging class of pliable machines known as soft robots is rapidly gaining traction. ...

Wolbachia and the paradox of growth regulation

Wolbachia and the paradox of growth regulation
2021-07-07
Despite having been formalized as a species in 1936, Wolbachia pipientis remains an elusive microbe. The reason why relates to the relationship it establishes with its hosts. Wolbachia lives inside the cells of 40% of the arthropods, in their majority insects, intertwined in a symbiosis so complex that it can no longer survive on its own. "Guessing what it takes to grow and manipulate it outside the host might not be possible", says Luís Teixeira, IGC principal investigator. And, so far, despite countless attempts, no one has succeeded in culturing this bacterium or modifying its genetic sequence. Before joining the team led by Luís Teixeira, Elves Duarte was interested in studying the symbiosis between ...

Researchers clarify reasons for low rate of employment among people with disabilities

Researchers clarify reasons for low rate of employment among people with disabilities
2021-07-07
East Hanover, NJ. July 7, 2021. A team of researchers identified nine meaningful reasons that prevent people with disabilities from seeking employment. Their findings provide a much-needed understanding of this population's motives for remaining unemployed, which can inform programs and policies that promote labor force participation of people with disabilities. The article, "Understanding Persons with Disabilities' Reasons for Not Seeking Employment" (doi: 10.1177/00343552211006773) was published in Rehabilitation Counseling Bulletin on April 15, 2021. The authors are Denise C. Fyffe, PhD, Anthony H. Lequerica, PhD, and John O'Neill, PhD, of Kessler Foundation; Courtney Ward-Sutton, PhD, and Natalie F. Williams, PhD, of Langston University; and Vidya Sundar, OT, PhD, ...

How seeds know it's a good time to germinate

2021-07-07
Palo Alto, CA--Dehydrated plant seeds can lay dormant for long periods--over 1,000 years in some species--before the availability of water can trigger germination. This protects the embryonic plant inside from a variety of environmental stresses until conditions are favorable for growth and survival. However, the mechanism by which the baby plant senses water and reactivates cellular activity has remained a mystery until now. New work jointly led by Carnegie's Yanniv Dorone and Sue Rhee and Stanford University's Steven Boeynaems and Aaron Gitler discovered a protein that plays a critical "go, or no-go" role in this process--halting germination if the soil's hydrological conditions are ...

CNIO researchers help to decipher the structure of the large molecular machine that activates mTOR

2021-07-07
The principle that form follows function does not only apply to design and architecture. It also applies to biology. Every organism is a universe that lives thanks to the activities of tens of thousands of nanomachines, whose functions depend on their forms. Biologists say macromolecular complexes instead of nanomachines and structure instead of form, but the idea is the same: know the form and you will understand the function. Now, a group at the Spanish National Cancer Research Centre (CNIO) has helped determine the structure of a nanomachine essential for the functioning of another, mTOR, which plays fundamental roles in ...

AI predicts diabetes risk by measuring fat around the heart

2021-07-07
A team led by researchers from Queen Mary University of London has developed a new artificial intelligence (AI) tool that is able to automatically measure the amount of fat around the heart from MRI scan images. Using the new tool, the team was able to show that a larger amount of fat around the heart is associated with significantly greater odds of diabetes, independent of a person's age, sex, and body mass index. The research is published in the journal Frontiers in Cardiovascular Medicine and is the result of funding from the CAP-AI programme, which is led by Barts Life Sciences, a research and innovation partnership between Queen Mary University of London and Barts Health NHS Trust. The distribution of fat in the body can influence a person's ...

Mucus and mucins may become the medicine of the future

2021-07-07
Many people instinctively associate mucus with something disgusting, but in fact, it has incredibly many valuable functions for our health. It keeps track of our important intestinal flora and feeds the bacteria. It covers all internal surfaces of our body, and, as a barrier to the outside world, it helps us protect ourselves from infectious diseases. This is because mucus acts as a filter that keeps the bacteria in or out, and the bacteria feed on the sugars in the mucus between meals. So, if we can produce the mucus that is already present in the body with the right sugars, it might be used in brand new medical treatments. Now, researchers from the DNRF Centre ...

Igniting plasmas in liquids

Igniting plasmas in liquids
2021-07-07
Physicists of Ruhr-Universität Bochum (RUB) have taken spectacular pictures that allow the ignition process of plasma under water to be viewed and tracked in real time. Dr. Katharina Grosse has provided the first data sets with ultra-high temporal resolution, supporting a new hypothesis on the ignition of these plasmas: In the nanosecond range, there is not enough time to form a gas environment. Electrons generated by field effects lead to the propagation of the plasma. The nanosecond plasma ignites directly in the liquid, regardless of the polarity of the voltage. The report from the Collaborative Research Centre 1316 "Transient Atmospheric Pressure Plasmas: from Plasma to Liquids to Solids" has been published in the Journal of Applied Physics and Rubin, the ...

For female vampire bats, an equal chance to rule the roost

2021-07-07
COLUMBUS, Ohio - Female vampire bats establish an egalitarian community within a roost rather than a society based on a clear hierarchy of dominance that is often seen in animal groups, a new study suggests. Researchers observed more than 1,000 competitions for food among a colony of 33 adult female bats and juveniles living in captivity, assigning a rank to each bat based on a calculation of wins and losses in those contests. The team found that, unlike in many mammal societies, the higher-ranking animal didn't necessarily win every bout over food, and there was a randomness to the ranking order - no specific quality they measured gave a bat a better chance at dominance, so any adult female had an equal opportunity to rank very high or very low on a scale of ...

LAST 30 PRESS RELEASES:

Reality check: making indoor smartphone-based augmented reality work

Overthinking what you said? It’s your ‘lizard brain’ talking to newer, advanced parts of your brain

Black men — including transit workers — are targets for aggression on public transportation, study shows

Troubling spike in severe pregnancy-related complications for all ages in Illinois

Alcohol use identified by UTHealth Houston researchers as most common predictor of escalated cannabis vaping among youths in Texas

Need a landing pad for helicopter parenting? Frame tasks as learning

New MUSC Hollings Cancer Center research shows how Golgi stress affects T-cells' tumor-fighting ability

#16to365: New resources for year-round activism to end gender-based violence and strengthen bodily autonomy for all

Earliest fish-trapping facility in Central America discovered in Maya lowlands

São Paulo to host School on Disordered Systems

New insights into sleep uncover key mechanisms related to cognitive function

USC announces strategic collaboration with Autobahn Labs to accelerate drug discovery

Detroit health professionals urge the community to act and address the dangers of antimicrobial resistance

3D-printing advance mitigates three defects simultaneously for failure-free metal parts 

Ancient hot water on Mars points to habitable past: Curtin study

In Patagonia, more snow could protect glaciers from melt — but only if we curb greenhouse gas emissions soon

Simplicity is key to understanding and achieving goals

Caste differentiation in ants

Nutrition that aligns with guidelines during pregnancy may be associated with better infant growth outcomes, NIH study finds

New technology points to unexpected uses for snoRNA

Racial and ethnic variation in survival in early-onset colorectal cancer

Disparities by race and urbanicity in online health care facility reviews

Exploring factors affecting workers' acquisition of exercise habits using machine learning approaches

Nano-patterned copper oxide sensor for ultra-low hydrogen detection

Maintaining bridge safer; Digital sensing-based monitoring system

A novel approach for the composition design of high-entropy fluorite oxides with low thermal conductivity

A groundbreaking new approach to treating chronic abdominal pain

ECOG-ACRIN appoints seven researchers to scientific committee leadership positions

New model of neuronal circuit provides insight on eye movement

Cooking up a breakthrough: Penn engineers refine lipid nanoparticles for better mRNA therapies

[Press-News.org] Identified an early neuronal dysfunction in Parkinson's that could help early diagnosis