PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Silicon in drinking water caused irreversible lung pathologies in rodents

Scientists of Immanuel Kant Baltic Federal University examined the effect of long-term silicon intake on the health of mice and rats.

2021-07-15
(Press-News.org) Bone density, skin and hair health, and the mobility of joints depend to a great extent on the microelement of silicon. We mostly get it with food, but silicon is also consumed with some biologically active additives that promise beauty, longevity, and youth. The element can also be found in drinking water of a natural origin: usually, it is included in the compound of sodium salt and metasiliconic acid. However, in the case of microelements, one should be extremely careful: a deficiency could lead to diseases, but an overdose could bring negative effects too.

Together with colleagues from the Chuvash State University and the Hamburg Medical University, scientists of Immanuel Kant Baltic Federal University studied the effect of prolonged silicon consumption in relatively small doses. They experimented on laboratory rats and mice. For several months the animals were given water with sodium metasilicate, one of the most common compounds of silicon; the concentration was ten milligrams per liter.

In the first phase of their experiment, the researchers took rats and mice pulmonary tissue samples two and three months after the introduction of silicon-contaminated water and didn't find any pathological changes. Then, they decided to triple the time of influence. Nine months later, the results were very different -- the animals' health greatly deteriorated. Their weight reduced in half, and the animals showed signs of lung fibrosis (the transformation of functional tissues into non-functional connective) of varying severity, and deformation of the bronchial tree. The epithelial walls between their alveoli were so depleted that in some cases they conjoined, and the total number and diameter of the alveoli decreased. Histological studies showed the presence of giant multinuclear Pirogov-Langhans cells that are common in tuberculosis and other severe lung diseases.

Remarkably, the negative impact on animals from the first phase of the experiment occurred six months after they were transferred from silicon-contaminated to clean water. Zones of increased density developed inside their lungs and along the bronchial tree areas. High concentration of lymphocytes (the main cells of the immune system) in these zones was indicative of inflammation.

"What we've seen during our experiment with rats and mice was very similar to silicosis, a chronic occupational disease that mostly affects miners and foundry workers. The constant use of silicon, whether in water or dietary supplements, may at first appear safe, although the damage increases unnoticeably. Research like this has been going on for years and is aimed to form an evidence base. The results are already included in the guidelines on microelement additives, which means we are actively changing the minds of the scientific community. Perhaps, lovers of "miracle pills" would be next", noted the head of research Valentina Gordova, a Candidate of Medical Sciences, and an Assistant Professor at the Department of Fundamental Medicine of the Immanuel Kant Medical Institute.

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

The virus trap

2021-07-15
To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami method. The strategy has already been tested against hepatitis and adeno-associated viruses in cell cultures. It may also prove successful against corona viruses. There are antibiotics against dangerous bacteria, but few antidotes to treat acute viral infections. Some infections can be prevented by vaccination but developing new vaccines is a long and laborious process. Now an interdisciplinary research team from the Technical University of Munich, the Helmholtz Zentrum München and ...

Study highlights how resilience is dynamic, not a static character trait

2021-07-15
A new study finds that resilience is a dynamic process, rather than a fixed trait - and suggests this may have significant ramifications for the business world. "Organizations are interested in cultivating a resilient workforce, because they want people who are able to remain committed to an organization and its goals over time," says Patrick Flynn, corresponding author of the study and an assistant professor of human resources management at North Carolina State University's Poole College of Management. "Our work here does a couple things," Flynn says. "First it finds that resilience is more of a process than a characteristic. Second, it identifies some of the ...

RUDN University chemists obtained an unusual planar nickel complex exhibiting magnetic properties

RUDN University chemists obtained an unusual planar nickel complex exhibiting magnetic properties
2021-07-15
RUDN University chemists obtained a metal-containing complex with an unusual planar architecture. The unexpected structure was formed due to the spontaneous fixation of carbon dioxide from the air during the reaction. This compound exhibits unusual magnetic properties (spin glass behaviour). This can be useful for creating memory storage devices. The results are published in the Journal of Organometallic Chemistry Coordination polymers are hybrid crystalline coordination compounds contained of infinitely repeating fragments (structural elements). These structural ...

Researcher creates cell lines to help treat mitochondrial diseases in children

Researcher creates cell lines to help treat mitochondrial diseases in children
2021-07-15
The mitochondrion has garnered quite the reputation for its role as the "powerhouse of the cell." These tiny, but mighty organelles play various life-sustaining roles, from powering our own cells and organs to fueling chemical and biological processes. But when they aren't working properly, a number of rare diseases can occur. Mitochondrial diseases are a group of debilitating genetic disorders that affect one in 5,000 people throughout the world, most of them being children. Along with these diseases come a variety of health concerns including, but not limited to, heart ...

Digital assistants created for e-commerce which adapt themselves to each shop's needs

2021-07-15
The pandemic has taught us that almost all companies have to sell on the internet. Bots are a technology that facilitates e-commerce. They are digital assistants that can answer customer queries about products that are sold or help to locate them, as well as supporting customers in the purchasing process. "In whatever language; and moreover, chatbots never get tired: They're available 24 hours a day, 365 days a year", said Jordi Cabot, the Universitat Oberta de Catalunya (UOC) researcher who created Xatkit, a company specialized in their development. This technology has existed for some time in big companies and is now also helping improve the digital competitiveness ...

RUDN University chemists propose a one-step synthesis of substances for medicine

RUDN University chemists propose a one-step synthesis of substances for medicine
2021-07-15
The RUDN University chemists have discovered a reaction for the synthesis of acetimidamides, heterocyclic compounds with biological activity that can be used for the synthesis of hormones, anti-inflammatory and other medical drugs. The reaction goes in one step with an efficiency of up to 96%. The results are published in the journal Molecules. Traditional chemical synthesis goes in several stages and requires the isolation and purification of intermediates at each stage. It is not efficient and not environmentally friendly as it increases the loss of substances and the consumption of solvents, and there is a problem of waste disposal. ...

Bioengineering discovery paves way for improved production of bio-based goods

Bioengineering discovery paves way for improved production of bio-based goods
2021-07-15
Scientists have uncovered a way to control many genes in engineered yeast cells, opening the door to more efficient and sustainable production of bio-based products. The study, published in Nucleic Acids Research by researchers from DSM's Rosalind Franklin Biotechnology Center in Delft, the Netherlands, and the University of Bristol, has shown how to unlock CRISPR's potential for regulating many genes simultaneously. Baker's yeast, or Saccharomyces cerevisiae to give it it's full name, is considered as a workhorse for biotechnology. Not only has it been used for producing bread and beer for thousands of years, but today it can also be engineered to produce an array of other useful compounds that form the basis of pharmaceuticals, fuels, and food additives. However, achieving ...

Tracking COVID-19 across Europe

Tracking COVID-19 across Europe
2021-07-15
According to the World Health Organization, a third wave of COVID infections is now all but inevitable in Europe. A COVID tracker developed by IIASA researcher Asjad Naqvi, aims to identify, collect, and collate various official regional datasets for European countries, while also combining and homogenizing the data to help researchers and policymakers explore how the virus spreads. While many comparisons have been made between the COVID-19 pandemic and similar events in history, one thing sets this pandemic apart from others: the unprecedented amount of knowledge and data that is constantly being generated to understand how the pandemic is unfolding. For a high-income region like Europe, the quality of information made available on a daily basis is exceptionally ...

ComCor study on SARS-CoV-2: where are French people catching the virus?

2021-07-15
The Institut Pasteur, in partnership with the French National Health Insurance Fund (CNAM), Santé publique France and the Ipsos Social Research Institute, recently presented the results of the ComCor epidemiological study on circumstances and places of infection with the SARS-CoV-2 virus. The aim of the study was to identify the socio-demographic factors, places visited and behaviors associated with a higher risk of infection with SARS-CoV-2. The study contains two parts: the first part describes the circumstances of infection of index cases diagnosed positive for SARS-CoV-2 during the curfew period, especially when the person considered as the source of infection is known; the ...

Caring for the physical health of those with mental illness

2021-07-15
PHILADELPHIA - People who struggle with serious mental illnesses are more likely to die early - about 10 to 30 years early - than those without mental illness from any cause. Many factors contribute to this disparity including poor access to care, undetected health conditions and difficulty managing chronic health conditions. Addressing physical illness in those with serious mental illness has been a major challenge. To address this, researchers tested a peer-led intervention called the Bridge that helps patients with mental illness prioritize their health, access health care and develop skills to self-manage their health. The approach showed a 50% reduction in emergency room use for those in ...

LAST 30 PRESS RELEASES:

12.5, the 1st Impact Factor of COMMTR released!

Circadian clock impact on cluster headaches funded by $2.4M NIH grant for UTHealth Houston research

Study identifies first drug therapy for sleep apnea

How old is your bone marrow?

Boosting biodiversity without hurting local economies

ChatGPT is biased against resumes with credentials that imply a disability — but it can improve

Simple test for flu could improve diagnosis and surveillance

UT Health San Antonio researcher awarded five-year, $2.53 million NIH grant to study alcohol-assisted liver disease

Giving pre-med students hands-on clinical training

CAMH research suggests potential targets for prevention and early identification of psychotic disorders

Mapping the heart to prevent damage caused by a heart attack

Study challenges popular idea that Easter islanders committed ‘ecocide’

Chilling discovery: Study reveals evolution of human cold and menthol sensing protein, offering hope for future non-addictive pain therapies.

Elena Beccalli, new rector of Università Cattolica del Sacro Cuore, takes office on 1st July

Pacific Northwest Research Institute uncovers hidden DNA mechanisms of rare genetic diseases

Empowering older adults: Wearable tech made easier with personalized support

Pennington Biomedical researchers partner on award-winning Long Covid study

Cooling ‘blood oranges’ could make them even healthier – a bonus for consumers

Body image and overall health found important to the sexual health of older gay men, according to new studies

Lab-grown muscles reveal mysteries of rare muscle diseases

Primary hepatic angiosarcoma: Treatment options for a rare tumor

Research finds causal evidence tying cerebral small-vessel disease to Alzheimer’s, dementia

Navigating the Pyrocene: Recent Cell Press papers on managing fire risk

Restoring the Great Salt Lake would have environmental justice as well as ecological benefits

Cannabis, tobacco use, and COVID-19 outcomes

A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes

Scientists document self-propelling oxygen decline in the oceans

Activating molecular target reverses multiple hallmarks of aging

Cannabis use tied to increased risk of severe COVID-19

How to make ageing a ‘fairer game’ for all wormkind

[Press-News.org] Silicon in drinking water caused irreversible lung pathologies in rodents
Scientists of Immanuel Kant Baltic Federal University examined the effect of long-term silicon intake on the health of mice and rats.