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Silicon in drinking water caused irreversible lung pathologies in rodents

Scientists of Immanuel Kant Baltic Federal University examined the effect of long-term silicon intake on the health of mice and rats.

2021-07-15
(Press-News.org) Bone density, skin and hair health, and the mobility of joints depend to a great extent on the microelement of silicon. We mostly get it with food, but silicon is also consumed with some biologically active additives that promise beauty, longevity, and youth. The element can also be found in drinking water of a natural origin: usually, it is included in the compound of sodium salt and metasiliconic acid. However, in the case of microelements, one should be extremely careful: a deficiency could lead to diseases, but an overdose could bring negative effects too.

Together with colleagues from the Chuvash State University and the Hamburg Medical University, scientists of Immanuel Kant Baltic Federal University studied the effect of prolonged silicon consumption in relatively small doses. They experimented on laboratory rats and mice. For several months the animals were given water with sodium metasilicate, one of the most common compounds of silicon; the concentration was ten milligrams per liter.

In the first phase of their experiment, the researchers took rats and mice pulmonary tissue samples two and three months after the introduction of silicon-contaminated water and didn't find any pathological changes. Then, they decided to triple the time of influence. Nine months later, the results were very different -- the animals' health greatly deteriorated. Their weight reduced in half, and the animals showed signs of lung fibrosis (the transformation of functional tissues into non-functional connective) of varying severity, and deformation of the bronchial tree. The epithelial walls between their alveoli were so depleted that in some cases they conjoined, and the total number and diameter of the alveoli decreased. Histological studies showed the presence of giant multinuclear Pirogov-Langhans cells that are common in tuberculosis and other severe lung diseases.

Remarkably, the negative impact on animals from the first phase of the experiment occurred six months after they were transferred from silicon-contaminated to clean water. Zones of increased density developed inside their lungs and along the bronchial tree areas. High concentration of lymphocytes (the main cells of the immune system) in these zones was indicative of inflammation.

"What we've seen during our experiment with rats and mice was very similar to silicosis, a chronic occupational disease that mostly affects miners and foundry workers. The constant use of silicon, whether in water or dietary supplements, may at first appear safe, although the damage increases unnoticeably. Research like this has been going on for years and is aimed to form an evidence base. The results are already included in the guidelines on microelement additives, which means we are actively changing the minds of the scientific community. Perhaps, lovers of "miracle pills" would be next", noted the head of research Valentina Gordova, a Candidate of Medical Sciences, and an Assistant Professor at the Department of Fundamental Medicine of the Immanuel Kant Medical Institute.

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[Press-News.org] Silicon in drinking water caused irreversible lung pathologies in rodents
Scientists of Immanuel Kant Baltic Federal University examined the effect of long-term silicon intake on the health of mice and rats.