PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Oncotarget | MTAP loss in metastatic breast cancer patients: Genomic landscape

Oncotarget | MTAP loss in metastatic breast cancer patients: Genomic landscape
2023-03-14
(Press-News.org)

“In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” 

BUFFALO, NY- March 14, 2023 – A new research paper was published in Oncotarget's Volume 14 on March 11, 2023, entitled, “Genomic landscape of metastatic breast cancer (MBC) patients with methylthioadenosine phosphorylase (MTAP) loss.”

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) upregulates de novo synthesis of purine (DNSP) and increases the proliferation of neoplastic cells. This increases the sensitivity of breast cancer cells to DNSP inhibitors such as methotrexate, L-alanosine and pemetrexed. In their recent study, Maroun Bou Zerdan, Prashanth Ashok Kumar, Elio Haroun, Nimisha Srivastava, Jeffrey Ross, and Abirami Sivapiragasam from SUNY Upstate Medical University and Foundation Medicine, Inc. analyzed 7,301 metastatic breast cancer (MBC) patients that underwent hybrid-capture based comprehensive genomic profiling (CGP). 

“We provide one of the first large analyses of the spectrum of GA [genomic alterations] occurring in MTAP deleted MBC with the hope that this would enable identifying potential therapeutic agents in the future.”

Tumor mutational burden (TMB) was determined on up to 1.1 Mb of sequenced DNA and microsatellite instability (MSI) was determined on 114 loci. Tumor cell PD-L1 expression was determined by IHC (Dako 22C3). 208 (2.84%) of MBC featured MTAP loss. MTAP loss patients were younger (p = 0.002) and were more frequently ER− (30% vs. 50%; p < 0.0001), triple negative (TNBC) (47% vs. 27%; p < 0.0001) and less frequently HER2+ (2% vs. 8%; p = 0.0001) than MTAP intact MBC. 

Lobular histology and CDH1 mutations were more frequent in MTAP intact (14%) than MTAP loss MBC (p < 0.0001). CDKN2A (100%) and CDKN2B (97%) loss (9p21 co-deletion) were significantly associated with MTAP loss (p < 0.0001). Likely associated with the increased TNBC cases, BRCA1 mutation was also more frequent in MTAP loss MBC (10% vs. 4%; p < 0.0001). As for immune checkpoint inhibitors biomarkers, higher TMB >20 mut/Mb levels in the MTAP intact MBC (p < 0.0001) and higher PD-L1 low expression (1–49% TPS) in the MTAP loss MTAP (p = 0.002) were observed.

“MTAP loss in MBC has distinct clinical features with genomic alterations (GA) affecting both targeted and immunotherapies. Further efforts are necessary to identify alternative means of targeting PRMT5 and MTA2 in MTAP-ve cancers to benefit from the high-MTA environment of MTAP-deficient cancers.”

 

Read the full research paper: DOI: https://doi.org/10.18632/oncotarget.28376 

Correspondence to: Abirami Sivapiragasam

Email: sivapira@upstate.edu 

Keywords: breast cancer, metastatic, MTAP loss

 

About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:

Twitter  Facebook  YouTube  Instagram  LinkedIn  Pinterest  LabTube Soundcloud

For media inquiries, please contact: media@impactjournals.com.

 

Oncotarget Journal Office

6666 East Quaker Str., Suite 1A

Orchard Park, NY 14127

Phone: 1-800-922-0957 (option 2)

###

END


[Attachments] See images for this press release:
Oncotarget | MTAP loss in metastatic breast cancer patients: Genomic landscape Oncotarget | MTAP loss in metastatic breast cancer patients: Genomic landscape 2

ELSE PRESS RELEASES FROM THIS DATE:

Tim Michalski selected as Jefferson Lab’s engineering manager

Tim Michalski selected as Jefferson Lab’s engineering manager
2023-03-14
NEWPORT NEWS, VA – The U.S. Department of Energy’s (DOE) Thomas Jefferson National Accelerator Facility has selected Tim Michalski to lead its Engineering Division as the Engineering Division Manager. In this role, Michalski oversees all aspects of the management and operation of the Engineering Division. The division includes more than 200 staff members and supports the Continuous Electron Beam Accelerator Facility and the lab’s growing project portfolio. “I am proud to name Tim as our newest Engineering Division Manager,” said Jefferson Lab Director Stuart Henderson. “Tim has ...

Princeton Chem, IAS uncover spatial patterns in distribution of galaxies

Princeton Chem, IAS uncover spatial patterns in distribution of galaxies
2023-03-14
In late 2021, Salvatore Torquato, on sabbatical from Princeton’s Department of Chemistry, reached across the aisle as it were and invited a young astrophysicist at the Institute for Advanced Study to apply the tools of statistical mechanics to his own work on the distribution of galaxies. The astrophysicist, Oliver Philcox, now a postdoc at the Simons Foundation, was intrigued. A year-long collaboration ensued. The questions at the heart of their unusual partnership were straightforward: can the statistical descriptors Torquato has worked with throughout his career find application in unlikely places like cosmology, and can they accurately characterize the complexity in the distribution ...

Researchers look to AI for decision-making in extreme situations

Researchers look to AI for decision-making in extreme situations
2023-03-14
Imagine you are a doctor managing the emergency room of a large hospital. You suddenly get a call reporting a mass shooting at a nearby concert. In 20 minutes, you will be responsible for triaging more than 200 patients with a range of injuries. You do not have enough staff or resources and the hospital policies are not designed for a situation this dire. “When people respond to emergencies, many decisions they face are quite predictable. They’re trained on them, and there’s policy,” said UMass Lowell’s Neil Shortland, associate professor in the School of Criminology and Justice Studies. “But every now and then, they get stuck with a really ...

Mix-and-match kit could enable astronauts to build a menagerie of lunar exploration bots

Mix-and-match kit could enable astronauts to build a menagerie of lunar exploration bots
2023-03-14
When astronauts begin to build a permanent base on the moon, as NASA plans to do in the coming years, they’ll need help. Robots could potentially do the heavy lifting by laying cables, deploying solar panels, erecting communications towers, and building habitats. But if each robot is designed for a specific action or task, a moon base could become overrun by a zoo of machines, each with its own unique parts and protocols. To avoid a bottleneck of bots, a team of MIT engineers is designing a kit of universal ...

Common dry cleaning chemical linked to Parkinson’s

2023-03-14
A common and widely used chemical may be fueling the rise of the world’s fastest growing brain condition – Parkinson’s disease. For the past 100 years, trichloroethylene (TCE) has been used to decaffeinate coffee, degrease metal, and dry clean clothes. It contaminates the Marine Corps base Camp Lejeune, 15 toxic Superfund sites in Silicon Valley, and up to one-third of groundwater in the U.S.  TCE causes cancer, is linked to miscarriages and congenital heart disease, and is associated ...

Molecular component of caffeine may play a role in gut health

2023-03-14
Brigham researchers studying how and why certain cell types proliferate in the gut found that xanthine, which is found in coffee, tea and chocolate, may play a role in Th17 differentiation   Insights may help investigators better understand gut health and the development of conditions such as inflammatory bowel disease The gut is home to a cast of microbes that influence health and disease. Some types of microorganisms are thought to contribute to the development of inflammatory conditions, such as inflammatory bowel disease (IBD), but the exact cascade of events that leads from microbes to immune cells to disease remains ...

Ochsner Health announces new Aortic Center; subscribes to cutting-edge imaging with Cydar Technology

Ochsner Health announces new Aortic Center; subscribes to cutting-edge imaging with Cydar Technology
2023-03-14
NEW ORLEANS, La. – Global death rates from aortic diseases have steadily increased over the past two decades. Studies show up to 8% of individuals will develop an aortic aneurysm during their lifetime, higher than rates of colon and lung cancer combined, and over 80% of ruptured aortic aneurysms cause sudden death.  To save lives and improve outcomes for patients with aortic disease of all kinds, Ochsner Health is excited to announce the establishment of The Ochsner Aortic Center. Outfitted with cutting-edge imaging technology that allows medical staff to make faster, easier, and safer decisions, this dedicated, comprehensive aortic center is now the ...

Aston Pharmacy School researchers develop new technique mixing oil and water to improve drug delivery

2023-03-14
A team of researchers from Aston University has developed a new technique that could be a game changer for the medical and drinks industries. The technology enables insoluble drug/oil to be dissolved in water. The technique is novel because it doesn’t just mix the two together to make an emulsion, it makes oil soluble in water and has the potential to revolutionise a variety of medical treatments and improve drug delivery. The technique was developed with Max Bio+ a spin out company founded by Professor Sunil Shah, a consultant ...

New guideline introduces recommendations for optimal timing of elective hip or knee arthroplasty

2023-03-14
ATLANTA — The American College of Rheumatology (ACR) and the American Association of Hip and Knee Surgeons (AAHKS) released a summary of its new guideline titled “the Optimal Timing of Elective Hip or Knee Arthroplasty for Patients with Symptomatic Moderate to Severe Osteoarthritis or Osteonecrosis Who Have Failed Nonoperative Therapy.” The ACR and AAHKS have worked together before, creating guidelines for Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty in 2017 and 2022. While those guidelines focus on which medications ...

Solving the Alzheimer’s disease puzzle: One piece at a time

Solving the Alzheimer’s disease puzzle: One piece at a time
2023-03-14
Researchers from Drexel University have uncovered a novel regulatory mechanism in the brain that is essential for making the right kinds of proteins that promote healthy brain function, and its malfunctioning may be an early contributor of the development of Alzheimer’s disease. Brain cells are continuously undergoing changes in response to environmental stimuli and to record new memories. Such complex brain capability relies on the ability of brain cells to generate different functional variants of the same protein using a process known as alternative RNA splicing. Recent studies have reported defects ...

LAST 30 PRESS RELEASES:

Researchers map 7,000-year-old genetic mutation that protects against HIV

KIST leads next-generation energy storage technology with development of supercapacitor that overcomes limitations

Urine, not water for efficient production of green hydrogen

Chip-scale polydimethylsiloxane acousto-optic phase modulator boosts higher-resolution plasmonic comb spectroscopy

Blood test for many cancers could potentially thwart progression to late stage in up to half of cases

Women non-smokers still around 50% more likely than men to develop COPD

AI tool uses face photos to estimate biological age and predict cancer outcomes

North Korea’s illegal wildlife trade threatens endangered species

Health care workers, firefighters have increased PFAS levels, study finds

Turning light into usable energy

Important step towards improving diagnosis and treatment of brain metastases

Maternal cardiometabolic health during pregnancy associated with higher blood pressure in children, NIH study finds

Mercury levels in the atmosphere have decreased throughout the 21st century

This soft robot “thinks” with its legs

Biologists identify targets for new pancreatic cancer treatments

Simple tweaks to a gene underlie the stench of rotten-smelling flowers

Simple, effective interventions reduce emissions from Bangladesh’s informal brick kilns

Ultrasound-guided 3D bioprinting enables deep-tissue implant fabrication in vivo

Soft limbs of flexible tubes and air enable dynamic, autonomous robotic locomotion

Researchers develop practical solution to reduce emissions and improve air quality from brick manufacturing in Bangladesh

Durham University scientists solve 500-million-year fossil mystery

Red alert for our closest relatives

3D printing in vivo using sound

Global Virus Network meeting unites Caribbean and Latin America to tackle emerging viral threats

MD Anderson Research Highlights for May 8, 2025

Study of Türkiye gold mine landslide highlights need for future monitoring

Researchers find new defense against hard-to-treat plant diseases

Characterization of research grant terminations at the National Institutes of Health

New study: high efficiency of severe thalassemia prevention with HTS based carrier screening

AI-designed DNA controls genes in healthy mammalian cells for first time

[Press-News.org] Oncotarget | MTAP loss in metastatic breast cancer patients: Genomic landscape