(Press-News.org) About The Study: In this national multicenter cohort study of inpatients with COVID-19, early administration of dexamethasone was associated with significantly reduced odds of mortality or discharge to hospice in those requiring supplemental oxygen or mechanical ventilation and/or extracorporeal membrane oxygenation but not in those requiring no supplemental oxygen or noninvasive positive pressure ventilation. These results support the continued use of systemic dexamethasone in patients hospitalized with COVID-19.
Authors: Laine E. Thomas, Ph.D., of Duke University in Durham, North Carolina, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2023.8516)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.8516?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=041723
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
END
Dexamethasone for inpatients with COVID-19 in a national cohort
JAMA Network Open
2023-04-17
ELSE PRESS RELEASES FROM THIS DATE:
Investigational drug may improve stem cell transplantation for multiple myeloma patients
2023-04-17
The standard treatment for patients with multiple myeloma often includes stem cell transplantation in which the patient’s own stem cells are harvested and stored while the patient receives intensive chemotherapy to kill the cancer. Then, the patient’s stem cells are returned to the patient to help with recovery. But for a significant proportion of patients, the number of stem cells that can be harvested is not optimal for transplant and negatively affects patient outcomes.
However, an international phase 3 clinical trial led by physicians at Washington University School of Medicine in St. Louis has shown that the investigational ...
University of Rochester researchers discover how to steer army of immune cells toward cancer
2023-04-17
Immunotherapy, particularly CAR T-Cell treatment for cancer, is extending the lives of many patients. But sometimes the therapy randomly migrates to places it shouldn’t go, tucking into the lungs or other noncancerous tissue and causing toxic side effects. A University of Rochester/Wilmot Cancer Institute team discovered the molecule responsible for guiding T cells toward tumors, setting the stage for scientists to improve upon the groundbreaking treatment.
The next step is to find a drug that can manipulate the ...
Poverty is the fourth greatest cause of U.S. deaths, analysis published in JAMA finds.
2023-04-17
Poverty has long been linked to shorter lives. But just how many deaths in the United States are associated with poverty? The number has been elusive – until now.
UC Riverside paper published Monday in the Journal of the American Medical Association associated poverty with an estimated 183,000 deaths in the United States in 2019 among people 15 years and older.
This estimate is considered conservative because the data is from the year just prior to the COVID-19 pandemic, which caused spikes in deaths worldwide and continues to take its toll.
The analysis found that only heart disease, ...
Steering phase-separated droplets to control mechanical properties of supramolecular peptide hydrogels
2023-04-17
Self-assembled peptide supramolecular hydrogels have shown great application prospects in various areas, including tissue engineering, drug delivery, and biosensing.
Precisely and flexibly controlling the mechanical properties of peptide hydrogels to match the targeted applications is important. The common methods to regulate the mechanical properties of supramolecular hydrogels generally include: changing the formula (different peptide sequences, adding cross-linking agents) or changing the environmental conditions (concentration, temperature, pH and ions), both of which inevitably change the chemical composition of the ...
Facile synthesis of high-performance perovskite oxides for acid–base catalysis
2023-04-17
Bifunctional acid−base catalysts are highly desirable for industrially relevant chemical processes. Owing to their ability to activate electrophiles and nucleophiles simultaneously, they allow the catalysis to proceed synergistically and cooperatively. Solid acid−base catalysts are particularly advantageous since they are reusable and result in no waste products. However, controlling the structure of such catalysts for cooperatively workable active sites is challenging. Simple and effective methods that enable the synthesis of high-performance solid acid−base ...
Quantum light source goes fully on-chip, bringing scalability to the quantum cloud
2023-04-17
An international team of researchers from Leibniz University Hannover (Germany), the University of Twente (Netherlands), and the start-up company QuiX Quantum has presented an entangled quantum light source fully integrated for the first time on a chip. “Our breakthrough allowed us to shrink the source size by a factor of more than 1000, allowing reproducibility, stability over a longer time, scaling, and potentially mass-production. All these characteristics are required for real-world applications such as quantum processors,” says Prof. Dr. Michael Kues, head of the Institute ...
Lipid molecules help to get stroke therapies into the brain
2023-04-17
Researchers from Tokyo Medical and Dental University (TMDU) find that, when a stroke therapy is linked to a specific kind of lipid and injected into the blood, it is taken up preferentially in the stroke-lesioned brain
Tokyo, Japan – To get therapies into the brain after a stroke, researchers are increasingly making use of the blood–brain barrier, which allows only certain molecules to pass from the blood into the brain. In a study published earlier this year in Molecular Therapy, ...
Ben-Gurion University researcher and colleagues pen 10 simple rules for socially responsible science
2023-04-17
BEER-SHEVA, Israel, April 17, 2023 – Scientific research must meet clear ethical guidelines to prevent harm to participants. However, research can also indirectly harm individuals and social groups, for example by shaping social perceptions and inspiring policy. Researchers receive little to no training on how to consider and minimize such harm.
To that end, Ben-Gurion University of the Negev's Dr. Niv Reggev and his international colleagues have published ten simple rules for socially responsible science. The ...
New approach estimates long-term coastal cliff loss
2023-04-17
In parts of California’s iconic mountainous coasts, breathtaking beauty is punctuated by brusque signs warning spectators to stay back from unstable cliffs. The dangers of coastal erosion are an all-too-familiar reality for the modern residents of these communities. Now, with a new tool, researchers are bringing historical perspective to the hotly debated topic of how to manage these disappearing coastlines.
Using a model that incorporates measurements of the amount of time coastal cliffs and their remnant deposits were exposed at the Earth’s surface, Stanford researchers found that the rate of cliff erosion in the past 100 years is ...
Long Covid smell loss linked to changes in the brain
2023-04-17
People living with long Covid who suffer from loss of smell show different patterns of activity in certain regions of the brain, a new study led by UCL researchers has found.
The research used MRI scanning to compare the brain activity of people with long Covid who lost their sense of smell, those whose smell had returned to normal after Covid infection, and people who had never tested positive for Covid-19.
Published in eClinicalMedicine, the observational study found that the people with long Covid smell loss had reduced brain activity and impaired communication between two parts of the brain which process ...
LAST 30 PRESS RELEASES:
Megalodon’s body size and form uncover why certain aquatic vertebrates can achieve gigantism
A longer, sleeker super predator: Megalodon’s true form
Walking, moving more may lower risk of cardiovascular death for women with cancer history
Intracortical neural interfaces: Advancing technologies for freely moving animals
Post-LLM era: New horizons for AI with knowledge, collaboration, and co-evolution
“Sloshing” from celestial collisions solves mystery of how galactic clusters stay hot
Children poisoned by the synthetic opioid, fentanyl, has risen in the U.S. – eight years of national data shows
USC researchers observe mice may have a form of first aid
VUMC to develop AI technology for therapeutic antibody discovery
Unlocking the hidden proteome: The role of coding circular RNA in cancer
Advancing lung cancer treatment: Understanding the differences between LUAD and LUSC
Study reveals widening heart disease disparities in the US
The role of ubiquitination in cancer stem cell regulation
New insights into LSD1: a key regulator in disease pathogenesis
Vanderbilt lung transplant establishes new record
Revolutionizing cancer treatment: targeting EZH2 for a new era of precision medicine
Metasurface technology offers a compact way to generate multiphoton entanglement
Effort seeks to increase cancer-gene testing in primary care
Acoustofluidics-based method facilitates intracellular nanoparticle delivery
Sulfur bacteria team up to break down organic substances in the seabed
Stretching spider silk makes it stronger
Earth's orbital rhythms link timing of giant eruptions and climate change
Ammonia build-up kills liver cells but can be prevented using existing drug
New technical guidelines pave the way for widespread adoption of methane-reducing feed additives in dairy and livestock
Eradivir announces Phase 2 human challenge study of EV25 in healthy adults infected with influenza
New study finds that tooth size in Otaria byronia reflects historical shifts in population abundance
nTIDE March 2025 Jobs Report: Employment rate for people with disabilities holds steady at new plateau, despite February dip
Breakthrough cardiac regeneration research offers hope for the treatment of ischemic heart failure
Fluoride in drinking water is associated with impaired childhood cognition
New composite structure boosts polypropylene’s low-temperature toughness
[Press-News.org] Dexamethasone for inpatients with COVID-19 in a national cohortJAMA Network Open