UHN Researchers publish ground breaking clinical trial in lung transplantation

Paradigm shift in lung preservation could increase donor organs and change practice worldwide

2023-04-20

(Press-News.org) (Toronto, April 20, 2023) Storing donor lungs for transplant at 10 degrees Celsius markedly increases the length of time the organ can live outside the body according to research led by a team of scientists at the Toronto Lung Transplant Program in the Ajmera Transplant Centre at the University Health Network (UHN).

The prospective multicenter, nonrandomized clinical trial study of 70 patients demonstrated that donor lungs remained healthy and viable for transplant up to four times longer compared to storage at the current standard of ice cooler preservation of around 4 degrees Celsius.

“The clinical impact of this study is huge. It’s a paradigm shift for the practice of lung transplant.”, says lead author Dr. Marcelo Cypel, Surgical Director of the Ajmera Transplant Centre and a surgeon within the Sprott Department of Surgery at UHN.

“I have no doubt that this will become the gold standard practice of lung preservation for the foreseeable future.”

Lungs available for transplant are currently limited by the length of time a donor organ can be kept viable. Increasing storage time allows for viable donor lungs to come from greater distances, increasing the potential for greater numbers of lungs becoming available for transplant and overcoming many of the hurdles around transplant logistics.

“In transplant, we still see a critical shortage of organs and people dying on the waitlist because there are not enough lungs to be transplanted.”, says Dr. Cypel, who is also a Professor in the Division of Thoracic Surgery, Department of Surgery at U of T.

“It’s a great accomplishment to see that our research is now having an impact, and that we can actually have more cases done at our centre, with continued outstanding clinical results. Better organ preservation also means better outcomes for patients.”

Results of the trial were published today in the New England Journal of Medicine Evidence: https://doi.org/10.1056/EVIDoa2300008

The trial took place over 18 months at UHN’s Toronto General Hospital, the Medical University of Vienna, and Hospital Universitario Puerta de Hierro-Majadahonda in Madrid.

"The ability to extend the lifespan of the donor organ poses several advantages. Ultimately, these advantages will allow for more lungs to be utilized across farther geographies and the ability to improve recipient outcomes by converting lung transplantation into a planned rather than urgent procedure.”, says study first author Dr. Aadil Ali, Adjunct Scientist at the Toronto General Hospital Research Institute.

Some advantages of this new 10 degrees Celsius standard for lung storage include the potential to reduce or eliminate the 24/7 schedule and urgency of lung transplant procedures. By increasing the length of time donor lungs are viable, transplant surgeries could become planned procedures, which avoids bumping scheduled surgeries and overnight transplantation. This advancement on practice comes at a critical time when hospital resources are stretched and there are increased surgical backlogs due to the pandemic.

The study also suggests the new preservation temperature will allow more time to optimize immunologic matching between donor and recipients, and the possibility of performing lung transplantation in a semi-elective rather than urgent fashion.

For more on the study watch Dr. Cypel's presentation of findings at a recent American Association for Thoracic Surgery event: 165. Extending… | The American Association for Thoracic Surgery | AATS.

Also, watch a video with Drs. Cypel and Ali discussing the foundational work that led to this breakthrough: The Future Now: Two Studies Offer a Sneak Peek into the Future of Organ Transplantation - YouTube.

The UHN-led international study was funded by the UHN Foundation.

Clinicaltrials.gov number, NCT04616365

About University Health Network

University Health Network consists of Toronto General and Toronto Western Hospitals, the Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, and The Michener Institute of Education at UHN. The scope of research and complexity of cases at University Health Network has made it a national and international source for discovery, education and patient care. It has the largest hospital-based research program in Canada, with major research in cardiology, transplantation, neurosciences, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. University Health Network is a research hospital affiliated with the University of Toronto. For more information: https://www.uhn.ca/

Media Contacts:

Christian Cote’ Christian.cote@uhn.ca

Catherine Danko Catherine.danko@uhn.ca

About UHN Foundation

Part of University Health Network (UHN), UHN Foundation raises funds for research, education and the enhancement of patient care at Toronto General and Toronto Western hospitals, Toronto Rehab and The Michener Institute of Education at UHN. With donor support, UHN Foundation is helping UHN pursue new knowledge to build a healthier world. For further information:

Media contact: Lisa Arai, Director, Brand Marketing, UHN Foundation, 416-278-6737, lisa.arai@uhn.ca

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UHN Researchers publish ground breaking clinical trial in lung transplantation

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