Julie Sutcliffe, PhD, receives SNMMI Mars Shot Fund award
2023-06-07
(Press-News.org) Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Julie Sutcliffe, PhD, professor of internal medicine and biomedical engineering, University of California–Davis, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging.
The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which was established to provide resources that translate visionary nuclear medicine imaging, radiopharmaceutical therapy and data science research or projects into tools or treatments that will help improve the lives of patients.
Sutcliffe’s Mars Shot grant was awarded based on her proposal, “Evaluating the integrin αvβ6-targeted molecular imaging agent [68Ga]Ga DOTA-5G as a diagnostic for lobular breast cancer.”
Invasive lobular breast carcinoma (LBC) is the second most common type of breast cancer and is often difficult to detect noninvasively by imaging such as mammography and 18F-FDG-PET, warranting the need for better molecularly targeted PET imaging agents for detection and monitoring.
“We have identified the integrin αvβ6 as a promising molecular target,” Sutcliffe said. “We designed a peptide, called DOTA-5G, that targets the integrin αvβ6 on tumor cells. We then further developed DOTA-5G into a theranostic pair, [68Ga]Ga DOTA-5G/[177Lu]Lu DOTA-ABM-5G, which is currently being tested in patients with metastatic pancreatic cancer. We are now proposing to use [68Ga]Ga DOTA-5G in patients with invasive LBC. We hypothesize that the agent will detect lesions, will be safe and well tolerated, and will be more sensitive than 18F-FDG PET.”
“This study will enable patients to receive more effective imaging that will improve their care by detecting disease earlier,” she added. “We therefore expect this molecularly targeted approach to have an immediate and much-needed benefit for this subpopulation of patients.”
Sutcliffe is professor of internal medicine and biomedical engineering, co-director of the Center for Molecular and Genomic Imaging, and director of the Radiochemistry Facility at the University of California–Davis. Sutcliffe’s research spans basic science, preclinical development and clinical translation with the ultimate goal of detecting and treating cancer earlier. She received her bachelor’s degree in chemistry from the University of Leicester, her master’s in synthetic organic chemistry from the University of London, and her doctorate in medicinal chemistry from King’s College London in England. Sutcliffe is a Fellow of SNMMI and also of the World Molecular Imaging Society and the American Institute for Medical and Biological Engineering.
###
About the SNMMI Mars Shot Research Fund
The ‘Mars Shot for Nuclear Medicine, Molecular Imaging, and Molecularly Targeted Radiopharmaceutical Therapy’ is a forward-looking glimpse into the future of nuclear medicine. Its goal is to provide resources for the translation of visionary nuclear medicine imaging, radiopharmaceutical therapy, and data science research or projects into tools or treatments helping improve the lives of patients.
About the Society of Nuclear Medicine and Molecular Imaging
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to advancing nuclear medicine and molecular imaging, vital elements of precision medicine that allow diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
SNMMI’s members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit www.snmmi.org.
END
ELSE PRESS RELEASES FROM THIS DATE:
2023-06-07
Reston, Virginia—The SNMMI Mars Shot Research Fund is excited to announce that Randy Yeh, MD, a radiologist and nuclear medicine physician at Memorial Sloan Kettering Cancer Center and assistant professor of radiology at Weill Cornell Medical College in New York, has been selected as the recipient of a $500,000 grant from the 2023 Mars Shot Fund. The grants recognize individuals who have made transformative impact in the field and elevated the value of nuclear medicine and molecular imaging.
The grant is one of five awarded in the inaugural year of the new SNMMI Mars Shot Research Fund, which ...
2023-06-07
KANSAS CITY, MO—June 7, 2023—The placenta, critical for healthy embryo development, is a multi- purpose organ with a precise lifespan—the length of a pregnancy. New research from the Stowers Institute for Medical Research suggests that further exploration of the placenta’s roles and capabilities may one day lead to insights for positive pregnancy outcomes.
The study published in Development on June 6, 2023, focuses on a unique property of many cells comprising the placenta that explains how these cells perform essential functional and physical ...
2023-06-07
More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe.
To date, only a handful of drugs exist to moderately slow its progression. There is no cure.
But CU Boulder researchers have identified a surprising new player in the disease—an ancient, virus-like protein best known, paradoxically, for its essential role in enabling placental development.
The findings ...
2023-06-07
Research Highlights:
58% of adults with Type 2 diabetes covered by Alabama Medicaid did not receive prompt outpatient care after hospitalization for heart failure.
African American and Hispanic adults with Type 2 diabetes were less likely to have post-discharge follow-up health visits, or if they did, the visits occurred nearly two to three days later compared to white adults.
Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, June 7, 2023
DALLAS, June 7, 2023 — More than half of Medicaid-covered adults in Alabama with Type 2 diabetes did not receive follow-up health care within the recommended two-week period following hospitalization for newly-diagnosed heart ...
2023-06-07
The first stars illuminated the Universe during the Cosmic Dawn and put an end to the cosmic "dark ages" that followed the Big Bang. However, the distribution of their mass is one of the great unsolved mysteries of the cosmos.
Numerical simulations of the formation of the first stars estimate that the mass of the first stars reached up to several hundred solar masses. Among them, the first stars with masses between 140 and 260 solar masses ended up as pair-instability supernovae (PISNe). PISNe are quite different from ordinary supernovae (i.e., Type II ...
2023-06-07
TORONTO, CANADA –A new study followed more than 7000 middle aged and older Canadians for approximately three years to understand whether higher rates of social participation were associated with successful aging in later life. They found that those who participated in volunteer work and those participating in recreational activities were more likely to maintain excellent health across the subsequent 3-year study period and less likely to develop physical, cognitive, mental, or emotional problems.
The researchers defined successful aging as freedom from any serious physical, cognitive, mental, or emotional conditions ...
2023-06-07
Certain crops, like greenhouse tomatoes, eggplant, peppers, and blueberries, rely on bumblebees for a style of pollination that only bumblebees can perform. Among growers, the preference can be for bigger-bodied bumblebees because they’re thought to be more efficient pollinators.
Enabled by a $750,000 grant from the National Institute of Food and Agriculture, the research team will investigate factors suspected of influencing bumblebee biology and body size, including climate change, wildfires, and the ...
2023-06-07
PHILADELPHIA – First-line ibrutinib (Imbruvica) plus venetoclax (Venclexta) led to high response and survival rates in patients with chronic lymphocytic leukemia (CLL) whether or not their cancer harbored high-risk genetic features typically associated with poor outcomes, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).
Patients with high-risk CLL, defined by deletion of 17p, mutated TP53, and/or unmutated immunoglobulin ...
2023-06-07
IOP Publishing (IOPP) is expanding its open access (OA) Environmental Research portfolio to address the urgent need for sustainable food solutions globally. Environmental Research: Food Systems, which supports the United Nation’s Sustainability Development Goals (SDGs), is an interdisciplinary forum for researchers working to achieve sustainable global food security.
Scientific innovations are key to transforming the global food system. Efficient and effective food supply enables the world to achieve progress on all 17 of the SDGs, from eliminating poverty ...
2023-06-07
A research team led by the Complexity Science Hub Vienna and the Medical University of Vienna has analysed the actual prevalence of Type 2 diabetes in Austria for the first time as part of a study. In addition to identifying clear regional differences, an alarming and previously unknown figure came to light: one in three people suddenly stop treatment and go without medication and/or medical check-ups for at least a year. And, as the study also showed, this group had a higher mortality rate than patients with diabetes who regularly access the care available to them. The results have ...
LAST 30 PRESS RELEASES:
[Press-News.org] Julie Sutcliffe, PhD, receives SNMMI Mars Shot Fund award
