Deciphering progesterone’s mechanisms of action in breast cancer
2023-07-10
(Press-News.org)
“The mechanisms underlying the observed effects of progesterone on breast cancer outcomes are unclear.”
BUFFALO, NY- July 10, 2023 – A new research perspective was published in Oncotarget's Volume 14 on July 1, 2023, entitled, “Deciphering the mechanisms of action of progesterone in breast cancer.”
A practice-changing, randomized, controlled clinical study established that preoperative hydroxyprogesterone administration improves disease-free and overall survival in patients with node-positive breast cancer. In this new perspective, researchers Gaurav Chakravorty, Suhail Ahmad, Mukul S. Godbole, Sudeep Gupta, Rajendra A. Badwe, and Amit Dutt from Tata Memorial Centre, Homi Bhabha National Institute and MIT World Peace University summarized evidence from their studies that preoperative hydroxyprogesterone administration may improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation.
“This research perspective is aimed to highlight the multipronged roles of progesterone in breast cancer that underlie the associated clinical response. We also present our opinion on the role of progesterone in overcoming endocrine resistance in the patients, especially by countering the genomic effects of overexpression and mutation of ESR1 and its targets.”
Non-coding RNAs, particularly DSCAM-AS1, play a regulatory role in this process, along with the upregulation of the kinase gene SGK1 and activation of the SGK1/AP-1/NDRG1 axis. Progesterone-induced modification of the progesterone receptor and estrogen receptor genomic binding pattern is also involved in orchestrating estrogen signaling in breast cancer, preventing cell migration and invasion, and improving patient outcomes. The team continues on to highlight the role of progesterone in endocrine therapy resistance, which could lead to novel treatment options for patients with hormone receptor-positive breast cancer and for those who develop resistance to traditional endocrine therapies.
“Overall, while preoperative hydroxyprogesterone administration appears to be a promising strategy for improving the prognosis of patients with node-positive breast cancer, the investigation of the mechanism of actions of progesterone in breast cancer remains an important area of research that holds great promise for improving patient outcomes.”
Read the full paper: DOI: https://doi.org/10.18632/oncotarget.28455
Correspondence to: Amit Dutt
Email: adutt@actrec.gov.in
Keywords: breast cancer, progesterone, DSCAM-AS1, endocrine therapy
About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
Twitter
Facebook
YouTube
Instagram
LinkedIn
Pinterest
LabTube
Soundcloud
Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28455
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact: media@impactjournals.com.
Oncotarget Journal Office
6666 East Quaker Str., Suite 1A
Orchard Park, NY 14127
Phone: 1-800-922-0957 (option 2)
###
END
ELSE PRESS RELEASES FROM THIS DATE:
2023-07-10
Hypertensive disorders of pregnancy such as preeclampsia and gestational hypertension occur in up to 10% of pregnancies and are associated with a three-fold increased risk of chronic hypertension and up to two-fold increased risk of cardiovascular disease when compared with healthy pregnancies. While the year after pregnancy is a critical time to address hypertension risk with lifestyle changes (healthy diet and exercise), the effects of lifestyle interventions on postpartum blood pressures are not well documented.
A new Boston University Chobanian & Avedisian School of Medicine study has found that there are few relevant studies on the ...
2023-07-10
We use plastics in almost every aspect of our lives. These materials are cheap to make and incredibly stable. The problem comes when we're done using something plastic — it can persist in the environment for years. Over time, plastic will break down into smaller fragments, called microplastics, that can pose significant environmental and health concerns.
The best-case solution would be to use bio-based plastics that biodegrade instead, but many of those bioplastics are not designed to degrade in backyard composting conditions. They must be processed in commercial composting facilities, which are not accessible in all regions of the ...
2023-07-10
URBANA, Ill. — For those whose primary experience with corn is the butter-drenched cob variety, it might come as a surprise that other forms of sweet corn are in trouble. A new University of Illinois Urbana-Champaign analysis shows sweet corn production for frozen and canned products has been steadily shrinking in the U.S. over the past 27 years, particularly in rainfed portions of the Midwest.
“The processing sweet corn industry [corn grown for canned and frozen products] was thriving in the U.S. throughout the 20th century. This type of production, ...
2023-07-10
Antiracist Structural Intervention at the Emory University Institutional Review Board
Francois Rollin, Vanessa Van Doren, Jessica Alvarez, Rebecca Rousselle, Jada Bussey-Jones
Although racial and ethnic categories are social constructs without inherent biologic or genetic meaning, race and ethnicity impact health outcomes through racism. The use of racial categories in biomedical research often misattributes the cause of health inequities to genetic and inherent biological differences rather than to racism. Improving research ...
2023-07-10
Philadelphia, July 10, 2023 – A long-standing and contentiously debated question is the extent to which US federal food assistance programs contribute to or deter healthy beverage intake. Findings of a new study in the Journal of Nutrition Education and Behavior, published by Elsevier, show that while beverage intake patterns rarely differed between mothers and young children who participated only in the Supplementation Nutrition Program for Women, Infants, and Children (WIC), only the Supplemental ...
2023-07-10
JULY 10, 2023, NEW YORK – A Ludwig Cancer Research study has discovered that the presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy, or immunochemotherapy. Esophageal cancer is the sixth leading cause of cancer mortality worldwide, and the incidence of esophageal adenocarcinoma has been climbing at a relatively swift clip over the past 40 years. Survival times for inoperable or metastatic forms of the cancer range from 6 to 12 months.
Led by Ludwig Oxford Director Xin Lu and ...
2023-07-10
ITHACA, N.Y. -- Humans make lots of irrational decisions in predictable ways, but what if we’re all just doing our best within the limits of our abilities?
Researchers were able to simulate human behaviors using a probabilistic finite automaton, a well-known model of limited computational power. They programmed the automatons to compete against each other in a wildlife poaching game, as either a rhino poacher or a ranger trying to stop the poaching.
When the automatons could remember everything, they settled into an optimal game strategy. But when researchers limited their memories, they took some decision-making shortcuts – the same ...
2023-07-10
COLUMBUS, Ohio – Major progress could be made in fighting the youth vaping epidemic with a complete restriction on sweet flavorings and cooling agents in both cartridge and disposable e-cigarette devices, according to a new study from the Center for Tobacco Research at The Ohio State University Comprehensive Cancer Center. The current U.S. Food and Drug Administration (FDA) flavor ban only applies to cartridge electronic cigarette devices.
A new study published in the Journal of Studies on Addiction and Drugs by researchers ...
2023-07-10
July 10, 2023 — The Population Council’s GIRL Center, and co-hosts AFIDEP, AMPLIFY Girls, Baobab Research Programme Consortium, Children’s Investment Fund Foundation, Coalition for Adolescent Girls, Exemplars in Global Health, FP2030, Girl Effect, Girls First Fund, Conrad N. Hilton Foundation, the National Democratic Institute (NDI), Plan International, PMNCH, Purposeful, Together for Girls, UNICEF, Women Deliver, and The World Bank Africa Gender Innovation Lab, are proud to host the “Girls Deliver: Pre-Conference on Adolescent Girls,” on July 16. This one-day global convening ...
2023-07-10
HOUSTON – (July 10, 2023) – One of the main ways cells “talk” to each other to coordinate essential biological activities such as muscle contraction, hormone release, neuronal firing, digestion and immune activation is through calcium signaling.
Rice University scientists have used light-activated molecular machines to trigger intercellular calcium wave signals, revealing a powerful new strategy for controlling cellular activity, according to a new study published in Nature Nanotechnology. This technology could lead to improved treatments ...
LAST 30 PRESS RELEASES:
[Press-News.org] Deciphering progesterone’s mechanisms of action in breast cancer
