PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Terasaki Institute for Biomedical Innovation awarded $2.2 million NIH grant to develop advanced treatment for diabetic foot ulcers

Terasaki Institute for Biomedical Innovation awarded $2.2 million NIH grant to develop advanced treatment for diabetic foot ulcers
2023-08-15
(Press-News.org)

(LOS ANGELES) – August 15, 2023 - A team of researchers from the Terasaki Institute for Biomedical Innovation (TIBI) and the University of Nebraska Medical Center (UNMC) has been awarded a multimillion-dollar grant from the National Institutes of Health to develop a superior, multi-pronged wound treatment for diabetic foot ulcers (DFUs).

DFUs remain a significant complication resulting from dysregulated internal pathophysiological conditions in diabetic patients. The unresolved diabetic wounds affect patients’ quality of life and can result in amputations or death. More than 6.5 million individuals suffer from diabetic wounds worldwide. Therefore, efforts toward improving current treatment modalities via an innovative approach may promote rapid healing and increased quality of life in patients. Treatment options include growth factors, anti-bacterial agents, protease inhibitors, and anti-inflammatories. Unfortunately, currently available dressings with tiny pores limit granulation tissue formation, prevent cell migration, increase infection rates, and promote scar formation.

“The microarchitecture of the dressing plays a pivotal role in rapid wound healing,” said TIBI scientist and principal investigator Johnson V. John, Ph.D. A more porous microstructure accelerates the migration of cells to the wound site to regenerate tissue and promote vascularization, or formation of blood vessels, for fast wound repair and closure. TIBI’s treatment approach contains a specific microarchitecture that accelerates wound healing, as well as novel small protein molecules, or peptides, to improve vascularization and infection control.

“The wound dressing proposed here offers superior features that will help millions of diabetic patients with chronic wounds,” said TIBI’s Director and CEO, Ali Khademhosseini, Ph.D. “It will be a more effective, versatile, less costly, and self-administered treatment which will not only increase compliance, but will greatly improve patients’ quality of life.”   

###

About the Terasaki Institute for Biomedical Innovation

The Terasaki Institute for Biomedical Innovation is accelerating the pace of translational research by supporting the world’s leading scientists with an open, entrepreneurial environment for bioengineering new materials, biological models, and advanced technologies to address critical challenges to the health of the planet and its people. The Institute’s worldwide collaborations with academic, clinical, and entrepreneurial partners provide a rich foundation for translating innovations to the real world.

Contact:
Stewart Han
President
Terasaki Institute for Biomedical Innovation
shan@terasaki.org

END


[Attachments] See images for this press release:
Terasaki Institute for Biomedical Innovation awarded $2.2 million NIH grant to develop advanced treatment for diabetic foot ulcers

ELSE PRESS RELEASES FROM THIS DATE:

Novel study shows greater metabolic response to animal versus plant proteins in young and older adults

Novel study shows greater metabolic response to animal versus plant proteins in young and older adults
2023-08-15
Protein from two ounce-equivalents (oz-eq) of animal-based protein foods provides greater essential amino acids (EAA) bioavailability than an equal two oz-eq of plant-based protein foods, according to scientists at Purdue University.1 The protein quality of a food or meal (i.e., the EAA content of a meal) is a major factor in determining how the body can use amino acids for muscle and whole-body protein building.2-4 The Dietary Guidelines for Americans (DGAs) puts an emphasis on consuming a variety of protein foods based on ounce-equivalent portions with similar nutritional ...

Gold buckyballs, oft-used nanoparticle ‘seeds’ are one and the same

Gold buckyballs, oft-used nanoparticle ‘seeds’ are one and the same
2023-08-15
HOUSTON – (Aug. 15, 2023) – Rice University chemists have discovered that tiny gold “seed” particles, a key ingredient in one of the most common nanoparticle recipes, are one and the same as gold buckyballs, 32-atom spherical molecules that are cousins of the carbon buckyballs discovered at Rice in 1985. Carbon buckyballs are hollow 60-atom molecules that were co-discovered and named by the late Rice chemist Richard Smalley. He dubbed them “buckminsterfullerenes” because their atomic structure reminded him of architect Buckminster Fuller’s geodesic domes, and the “fullerene” family has grown to include dozens of hollow ...

Weaker transcription factors are better when they work together

Weaker transcription factors are better when they work together
2023-08-15
HOUSTON – (Aug. 15, 2023) – Bioengineers can tailor the genomes of cells to create “cellular therapies” that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch on bioengineered genes without occasionally turning on some of the cell’s naturally occurring genes. In a study published online in Cell, bioengineers from Rice University, Boston University, Harvard Medical School, Dartmouth College and Harvard University’s Wyss Institute showed they could all but eliminate such “off-target” gene ...

Treating back-to-school ear infections without antibiotic resistance (video)

2023-08-15
SAN FRANCISCO, Aug. 15, 2023 — “Back-to-school” season means buying pens and paper, figuring out the new bus route, and … earaches. Doctors typically treat these infections with antibiotics, but children don’t always complete the full course, accelerating resistance to these medications. Today, researchers report developing a single-use nanoscale system that’s unlikely to generate resistance. Using a compound similar to bleach in test animals, they show it can kill off one type of bacterium that causes ear infections, and it could someday be easily applied as a gel. The researchers will present their results today at the fall meeting of the American Chemical ...

Discarded aloe peels could be a sustainable, natural insecticide (video)

Discarded aloe peels could be a sustainable, natural insecticide (video)
2023-08-15
SAN FRANCISCO, Aug. 15, 2023 — Aloe barbadensis, commonly known as aloe vera, has been used for thousands of years to treat skin ailments, promote digestive health and heal wounds. But while aloe vera gel is in high demand, the peels are thrown away as agricultural waste. Today, scientists report that these peels, or rinds, can ward off bugs, acting as a natural insecticide. They have identified several bioactive compounds in extracts from the peels that deter insects from feasting on crops. The researchers will present their results at the fall meeting of the American Chemical Society (ACS). ACS Fall ...

Microgreens and mature veggies differ in nutrients, but both might limit weight gain

Microgreens and mature veggies differ in nutrients, but both might limit weight gain
2023-08-15
SAN FRANCISCO, Aug. 15, 2023 — Young vegetables known as microgreens are reputed to be particularly good for health. Now, researchers are trying to find out if microgreens — which can easily be grown at home — are the superfood they’re claimed to be, and how they compare to mature veggies. Results to date show their nutritional profiles differ, as do their effects on gut bacteria. Yet, tests in mice suggest that both microgreen and mature vegetables can limit weight gain. The researchers will present their results today at the fall meeting ...

Detecting risk of metastatic prostate cancer in Black men

2023-08-15
SAN FRANCISCO, Aug. 15, 2023 — To explore why prostate cancer disproportionately sickens and kills Black men, researchers are looking to another disorder, diabetes, which alters metabolism. They used this approach in a preliminary clinical trial and today report the identification of four metabolism-related biomarkers linked to an increased risk of metastatic prostate cancer in men of West African heritage. This discovery could lead to improved testing and treatments for these patients. The researchers will present their results at the fall ...

City of Hope researchers identify biomarkers that may detect risk of advance prostate cancer in Black men

City of Hope researchers identify biomarkers that may detect risk of advance prostate cancer in Black men
2023-08-15
LOS ANGELES — Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, have identified a cell metabolism process found in men with diabetes and metastatic prostate cancer that could one day lead to improved testing and treatments for Black men with these diseases. The research will be highlighted in the press program for the American Chemical Society (ACS) Fall 2023, a hybrid meeting that ...

Scientists pinpoint the microbes essential to making traditional mozzarella

2023-08-15
Mozzarella is far more than just a pizza topping. A unique Italian cheese, buffalo mozzarella from Campania has been recognized as a delicacy and protected under EU law for nearly 30 years. But what makes this mozzarella so special? The ingredients are simple: water buffalo milk, rennet, and natural whey starter, processed using fresh water and brine. But the natural whey starter contains microbes that are crucial to developing the mozzarella. Scientists from Italy used high-throughput 16S rRNA amplicon ...

Teachers perceive more conflict with Black boys, closer relationships with white girls

2023-08-15
A team of researchers led by a Virginia Commonwealth University professor found that teachers, regardless of race, perceived the most conflict with Black boys and the least conflict with white girls in their classrooms. Teachers also perceived their relationships with Black boys as increasing in conflict at higher rates than with white and female children across kindergarten through second grade, according to findings published this summer in the Journal of School Psychology. The study analyzed nationally representative survey data from 9,190 participants – teachers who evaluated relationships ...

LAST 30 PRESS RELEASES:

Students with overprotective parents are more vulnerable to anxiety during their transition to university, researchers find

Seagrass as a carbon sponge?

Study shows how smoking drives pancreatic cancer

Unveiling the identity of Crohn's disease T cells

Frontiers Forum Deep Dive series: Biological ‘moonshot’ accelerates efforts to genetically map life on Earth

After early-life stress, astrocytes affect behaviour

UMD developing AI-powered warning system to predict disease tied to extreme weather

New study links grain foods to healthier diet patterns, metabolic health and everyday accessibility

Korea University College of Medicine explores 'Health for Humanity' at K-CLUB International Symposium with world-renowned scholars

Regular walking prevents chronic back pain

Broccoli seeds can spread resistance to multiple fungicides

New AI tool addresses accuracy and fairness in data to improve health algorithms

Researchers design robot that can find, pick hidden strawberries

Effective urban planning from real-world population tracking

EWG study: PFAS water treatment has double benefits, cutting toxic PFAS and carcinogens

MIT Press expands Direct to Open (D2O) open access model in 2026 with publishing partners

Pork protein improves recovery, mood and inflammation in military cadets following combat fitness test

Mount Sinai unveils Emergency Department transformation after extensive upgrades and renovations

Uncovering language learning strategies for Japanese university students in STEM

The invisible influence: How cultural cognitive biases influence visuomotor adaptations

New sugar-based stabilizer keeps sweat sensors working under acidic conditions

Stress & Stars: Two more ERC Starting Grants for ISTA

ERC honors Hebrew University scientists for pioneering brain and language studies

Theresa Rienmüller and Robert Winkler receive ERC Starting Grants

ERC grant helps to explore innovative approaches to improve the diagnosis of ADHD in adults

Hidden chemistry of Earth’s core revealed by how it froze

IRB Barcelona researchers uncover a new strategy to tackle obesity by activating brown fat

Biological ‘moonshot’ accelerates efforts to genetically map life on Earth

New papers reveal how gut-brain interactions shape eating behaviors

Meal timing in later life may matter for health and longevity

[Press-News.org] Terasaki Institute for Biomedical Innovation awarded $2.2 million NIH grant to develop advanced treatment for diabetic foot ulcers