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Space travel depletes red blood cells and bone, but bone marrow fat may come to the rescue

Study in Nature Communications could improve health in space and on Earth

Space travel depletes red blood cells and bone, but bone marrow fat may come to the rescue
2023-08-21
(Press-News.org) A study of 14 astronauts suggests that while space travel depletes red blood cells and bone, the body can eventually replenish them back on Earth with the help of fat stored in the bone marrow. The study, published in Nature Communications, has important implications for health in space and on Earth.

“We found that astronauts had significantly less fat in their bone marrow about a month after returning to Earth,” said senior study author Dr. Guy Trudel, a rehabilitation physician and researcher at The Ottawa Hospital and professor at the University of Ottawa. “We think the body is using this fat to help replace red blood cells and rebuild bone that has been lost during space travel.”

This study builds on Dr. Trudel’s previous research which showed that during space travel, astronauts’ bodies destroyed 54 percent more red blood cells than they normally would on Earth, resulting in what is known as “space anemia.” This research is part of MARROW, a made-in-Ottawa experiment looking at bone marrow health and blood production in space, with funding from the Canadian Space Agency.

“Thankfully, anemia isn’t a problem in space when your body is weightless, but when landing on Earth and potentially on other planets or moons with gravity, anemia would affect energy, endurance, and strength and could threaten mission objectives,” said Dr. Trudel. “If we can find out exactly what’s controlling this anemia, we might be able to improve prevention and treatment.”

The new study involved MRI scans of the astronauts’ bone marrow at multiple time points before and after a six-month mission at the International Space Station. The researchers found a 4.2 percent decrease in bone marrow fat about a month after returning to Earth. This gradually returned to normal levels and was closely associated with increased production of red blood cells and restoration of bone.

“Since red blood cells are made in the bone marrow and bone cells surround the bone marrow, it makes sense that the body would use up the local bone marrow fat as a source of energy to fuel red blood cell and bone production,” said Dr. Trudel. “We look forward to investigating this further in various clinical conditions on Earth.”

The research also suggests that younger astronauts may have an increased ability to harness the energy from bone marrow fat, and that female astronauts’ bone marrow fat increased more than expected after a year.

As a rehabilitation physician, most of Dr. Trudel’s patients are anemic and have lost muscle and bone mass after being ill for a long time with limited mobility. Anemia hinders their ability to exercise and recover muscle and bone mass. “I’m hopeful that this research will help people recover from immobility on Earth as well as in space,” said Dr. Trudel. “Our research could also shed light on diseases such as osteoporosis, metabolic syndrome, aging and cancer, which are associated with increases in bone marrow fat.”

Dr. Trudel recently received the 2023 Compelling Results Award for Human Health in Space for his research on space anemia, jointly presented by NASA, the Center for the Advancement of Science in Space and the American Astronautical Society.

Full reference: “Bone marrow adiposity modulation after long duration spaceflight in astronauts”. Tammy Liu, Gerd Melkus, Tim Ramsay, Adnan Sheikh, Odette Laneuville & Guy Trudel. Nature Communications volume 14, Article number: 4799 (2023). Published 09 August 2023.

Funding and support: The MARROW study is funded by the Canadian Space Agency. Dr. Scott Smith and the NASA Biochemical Profile Protocol provided support. The Ottawa Hospital Research Institute and the University of Ottawa Faculty of Medicine have also supported this research through the Ottawa Methods Centre and Blueprint Translational Research Group’s Excelerator program.

The Ottawa Hospital (TOH) is one of Canada’s top learning and research hospitals where we are guided by our vision to provide the world-class and compassionate care we would all want for our loved ones. Our multi-campus hospital, affiliated with the University of Ottawa, is home to the Regional Trauma Centre and Cancer Centre, and to discoveries that are adopted globally. Backed by generous support from the community, we are focused on reshaping the future of health care to improve the health of our diverse population of patients from Eastern Ontario, Western Quebec, and Nunavut. For more information, visit www.ohri.ca.

The University of Ottawa is home to over 50,000 students, faculty and staff, who live, work and study in both French and English. Our campus is a crossroads of cultures and ideas, where bold minds come together to inspire game-changing ideas. We are one of Canada’s top 10 research universities—our professors and researchers explore new approaches to today’s challenges. One of a handful of Canadian universities ranked among the top 200 in the world, we attract exceptional thinkers and welcome diverse perspectives from across the globe. www.uottawa.ca

Media Contact
Amelia Buchanan
Senior Communication Specialist
613-297-8315
ambuchanan@ohri.ca

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Space travel depletes red blood cells and bone, but bone marrow fat may come to the rescue

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[Press-News.org] Space travel depletes red blood cells and bone, but bone marrow fat may come to the rescue
Study in Nature Communications could improve health in space and on Earth