Muvalaplin, an oral small molecule inhibitor of lipoprotein(a) formation

JAMA

2023-08-28

(Press-News.org) About The Study: Muvalaplin was not associated with tolerability concerns and lowered lipoprotein(a) (Lp[a]) levels up to 65% following daily administration for 14 days in this first-in-human phase 1 study involving healthy participants. Lipoprotein(a) is associated with atherosclerotic disease and aortic stenosis. Longer and larger trials will be required to further evaluate safety, tolerability, and effect of muvalaplin on Lp(a) levels and cardiovascular outcomes.

Authors: Stephen J. Nicholls, M.B.B.S., Ph.D., of Monash University in Clayton, Victoria, Australia, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2023.16503)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being released to coincide with presentation at the European Society of Cardiology Congress 2023.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.16503?guestAccessKey=d859c2e4-3c05-4b02-8fca-a109964432bd&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082823

END

ELSE PRESS RELEASES FROM THIS DATE:

Stevens researchers take aim at weather forecasters’ biggest blindspot

2023-08-28

Anyone who’s been caught in an unexpected downpour knows that weather forecasting is an imperfect science. Now, researchers at Stevens Institute of Technology are taking aim at one of meteorologists’ biggest blind spots: extremely short-term forecasts, or nowcasts, that predict what will happen in a given location over the next few minutes. “This isn’t just about whether you should take your umbrella with you when you go on a walk,” said Temimi. “The forecasts that we’re missing – the ones that look ...

Projected outcomes of optimized statin and ezetimibe therapy in veterans with coronary artery disease

2023-08-28

About The Study: In this study of 111,000 U.S. military veterans with coronary artery disease, suboptimal lipid-lowering therapy was prevalent in the clinical setting. Optimization of statin therapy was projected to produce clinically relevant reductions in the risks of death and cardiovascular events. Despite a lesser lipid-lowering efficacy of ezetimibe, its widespread use on a population level in conjunction with optimized statin therapy may be associated with further meaningful reductions in cardiovascular risk. Authors: Gregory G. Schwartz, M.D., Ph.D., of the Rocky Mountain Regional VA Medical Center in Aurora, Colorado, is the corresponding author. To ...

COVID-19 virus is evolving rapidly in white-tailed deer

2023-08-28

COLUMBUS, Ohio – White-tailed deer across Ohio have been infected with the virus that causes COVID-19, new research has found – and the results also show that viral variants evolve about three times faster in deer than in humans. Scientists collected 1,522 nasal swabs from free-ranging deer in 83 of the state’s 88 counties between November 2021 and March 2022. More than 10% of the samples were positive for the SARS-CoV-2 virus, and at least one positive case was found in 59% of the counties in which testing took place. Genomic analysis showed that at least 30 infections in deer had been introduced by humans – ...

Are cannabis products safe and effective for reducing symptoms in children with cancer?

2023-08-28

A recent analysis of all relevant published studies reveals a lack of evidence to determine the dosing, safety, and efficacy of medical marijuana or cannabis-containing products for managing symptoms experienced by children with cancer. The analysis is published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Although treatments for childhood cancer have improved significantly, even leading to cures for many patients, many children still suffer from symptoms such as pain, anxiety, and weight loss related to cancer and its treatment. Over the last decade, cannabis ...

First defence against devastating ToCSV tomato virus explored

2023-08-28

How tomato plants defend themselves against a devastating ‘young’ Southern African virus has now been investigated at a molecular genetics level for the first time by researchers at the University of Johannesburg (UJ). The Ty-1 gene is known to confer resistance to the well-known tomato yellow leaf curl virus (TYLCV). UJ researchers investigated what happens when tomato plants that harbour the Ty-1 gene are infected with the relatively unknown tomato curly stunt virus (ToCSV). They found a link between tolerance to ToCSV, a plant defence called viral DNA methylation, and Ty-1 gene activity. The research is published ...

Sleep can be most restful for older adults when nighttime temperature range is between 68 to 77 °F, study finds

2023-08-28

New research finds that sleep can be most efficient and restful for older adults when nighttime bedroom ambient temperature ranges between 68 to 77 °F. The authors observed an overall trend: a 5-10 % drop in sleep efficiency as the nighttime ambient temperature increases from 77°F to 86°F. Importantly, this research also reveals substantial between-individual differences in optimal bedroom temperature. “These results highlight the potential to enhance sleep quality in older adults by optimizing home thermal environments and emphasizing the importance ...

New study reveals anti-cancer properties in Kencur ginger

2023-08-28

You may know it as an aromatic spice to add flavor to your dishes or as a soothing herbal remedy to use for upset stomachs, but researchers from Osaka Metropolitan University have uncovered promising findings that Kencur, a tropical plant in the ginger family native to Southeast Asia, possesses anti-cancer effects. Led by Associate Professor Akiko Kojima of the Graduate School of Human Life and Ecology, the researchers demonstrated that Kencur extract and its main active component, ethyl p-methoxycinnamate (EMC), significantly suppressed cancer cell growth at the cellular and animal levels. While previous studies on EMC indicated its anti-cancer potential by decreasing the expression ...

New type of visible-light responsive photocatalyst is efficient, stable and very economical

2023-08-28

A new type of versatile economical photocatalyst that harnesses the visible portion of the sunlight spectrum has been developed by researchers from the University of Johannesburg. It is simple to manufacture. Currently, economical photocatalysts only ‘use’ the UV spectrum of sunlight. The new photocatalyst harnesses about a third of the visible light spectrum. The extremely stable, powder-form three-component photocatalyst is built from graphitic carbon (89% of mass), a modified calixarene (10%) and a niobium-containing MXene (1%). Researchers at the University of Johannesburg have developed a new type of photocatalyst that harnesses the visible ...

Low cost, high efficiency, multiple colors at the same time!

2023-08-28

A research team led by Dr. Jung-dae Kwon from the Department of Energy & Electronic Materials at the Korea Institute of Materials Science(KIMS) has succeeded in realizing the world's first transparent thin-film solar cell on a flexible substrate that exhibits different reflective colours and does not significantly reduce solar cell's efficiency. KIMS is a government-funded research institute under the Ministry of Science and ICT. This is a technology that achieves reflective colour only a single material by periodically incorporating hydrogen into zinc oxide material doped with aluminium, which is a transparent electrode, to induce a refractive index difference. ...

New guidance on take-home naloxone for community overdose responders

2023-08-28

New guidance aimed at helping standardize community overdose response and take-home naloxone kits across Canada is published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.230128. The guidance is an important document to optimize the effectiveness of take-home naloxone to save lives. The guidance was developed by a panel of experts, including people with lived experience of drug use and overdose response, front-line and harm-reduction workers, public health professionals, clinicians and academics with expertise in harm reduction across Canada. ...

Muvalaplin, an oral small molecule inhibitor of lipoprotein(a) formation

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: