During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered
Promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity
2023-09-14
(Press-News.org)
During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity.
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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002284
Article Title: A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans
Author Countries: Germany, United Kingdom
Funding: see manuscript
END
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Key points:
Protein aggregation in certain tissues is a hallmark of diseases such as neurodegeneration and occurs during ageing, but little is known about how protein quality control mechanisms acting to prevent toxic protein build-up vary on a tissue-by-tissue basis.
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[Press-News.org] During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered
Promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity
