New perspectives on MAFLD
(Press-News.org) Fatty liver disease is a condition characterised by a build-up of fat in the liver and is the most common chronic liver disease that affects over one billion people. Over time, this can lead to complications including cirrhosis, liver failure, liver cancer, and heart health issues. The disease is now known as metabolic (dysfunction) associated fatty liver disease (MAFLD). This is because the disease is now understood to be linked to metabolic factors, such as obesity, insulin resistance, and diabetes.
MAFLD is a multisystem disorder with a heterogeneous disease course and outcomes. This means that it can affect multiple organs, and the course of the disease can vary from person to person. Some people with MAFLD may have no symptoms, while others may develop serious complications, such as liver cirrhosis or liver cancer. The diagnosis of MAFLD is often delayed, sometimes for decades. This is because the disease is often asymptomatic in the early stages. Additionally, there is no single test that can definitively diagnose MAFLD.
Early diagnosis of MAFLD is essential for effective treatment. This is because early treatment can help prevent the disease's progression and the development of complications. Many pharmacological and non-pharmacological treatments can be more effective in early disease. For example, lifestyle changes, such as losing weight, eating a healthy diet, and exercising regularly, can help to improve liver function and reduce the risk of complications.
It is important to stratify patients to develop effective treatments. This means grouping patients based on their individual characteristics, such as their disease severity, complications risk, and treatment response. This will help to ensure that patients receive the most appropriate treatment for their individual needs.
A new set of diagnostic criteria for MAFLD has been developed. An international group of experts developed these criteria to help in addressing these issues. The criteria apply to all ages and consider age-related factors. This means that they can be used to diagnose MAFLD in people of all ages, from children to adults.
The new diagnostic criteria for MAFLD have met their promise. This is because they are accurate and reliable in diagnosing MAFLD and idenftying the patients at high risk of disease complications.
The development of the new criteria has created a positive momentum for change. This is because it has led to increased awareness of MAFLD and has paved the way for further research and clinical trials. Therefore, the new criteria represent a significant step forward in diagnosing and treating this disease.
About the eGastroenterology
eGastroenterology is a new, open-access, and open peer-reviewed BMJ Journal, which focuses on basic, clinical, translational, and evidence-based medicine research in all areas of gastroenterology (including hepatology, pancreatology, esophagology, and gastrointestinal surgery).
For more information, please visit: egastroenterology.bmj.com and follow us on Twitter (@eGastro_BMJ).
ELSE PRESS RELEASES FROM THIS DATE:
Most artificially intelligent systems are based on neural networks, algorithms inspired by biological neurons found in the brain. These networks can consist of multiple layers, with inputs coming in one side and outputs going out of the other. The outputs can be used to make automatic decisions, for example, in driverless cars. Attacks to mislead a neural network can involve exploiting vulnerabilities in the input layers, but typically only the initial input layer is considered when engineering a defense. For the first time, researchers augmented a neural network’s inner layers with a process involving random noise to improve its resilience.
Artificial intelligence (AI) ...
Scientists have used genomics to reveal distinct sexual networks for syphilis transmission, defined geographically or by sexual preference, among a background of wider circulation in England. They also show a presence of drug resistance in the majority of cases.
By grouping closely related strains of the bacterium that causes syphilis – Treponema pallidum –, researchers demonstrate how a large number of cases are linked together. Researchers from the Wellcome Sanger Institute and their collaborators at the UK Health Security Agency (UKHSA)* sequenced ...
The U.S. Department of Energy Office of Science, or DOE-SC, is investing in machine learning, a type of artificial intelligence, to accelerate the speed of research and development in nuclear science. Michigan State University researchers at the Facility for Rare Isotope Beams, or FRIB, are leading five of these new grant projects.
These projects aim to enhance the breadth of FRIB’s activities, covering nuclear physics experiments and theory, as well as particle accelerator operations.
FRIB is a DOE-SC user facility, meaning that these advances will serve ...
The University of Kentucky Markey Cancer Center announced today that it has earned a National Cancer Institute “Comprehensive” Cancer Center designation, the highest level of recognition awarded by the NCI. Markey is the first and only center in Kentucky to achieve this designation, and the next-closest Comprehensive Cancer Center is nearly 200 miles from Lexington. There are currently only 72 NCI-Designated Cancer Centers in the country, and 56 of those are Comprehensive Cancer Centers.
As the federal government’s principal ...
Ratings on platforms such as Yelp and TripAdvisor can greatly impact high-priced New York City restaurants that service tourists, but have less of an effect on restaurants frequented by “locals” outside of tourist areas, according to new Cornell research.
“In neighborhoods frequented by ‘locals,’ the advent and expansion of internet-based ratings platforms did not result in greater disparities in restaurant sales despite how ubiquitous they are and how frequently we anecdotally use them,” said Jason Greenberg, associate ...
The feel of a cat’s fur can reveal some information, but seeing the feline provides critical details: is it a housecat or a lion? While the sound of fire crackling may be ambiguous, its scent confirms the burning wood. Our senses synergize to give a comprehensive understanding, particularly when individual signals are subtle. The collective sum of biological inputs can be greater than their individual contributions. Robots tend to follow more straightforward addition, but Penn State researchers have now harnessed the biological concept for application in artificial intelligence (AI) to develop ...
Genetically speaking, we are individuals different from each other because of slight variations in our DNA sequences – so-called genetic variants – some of which have dramatic effects we can see and comprehend, from the color of our eyes to our risk for developing schizophrenia – a debilitating psychiatric condition affecting many millions worldwide. For several years, scientists have studied the entire genomes of thousands of people – called genome-wide association studies, or GWAS – to find approximately 5,000 genetic variants associated with schizophrenia.
Rochester Institute of Technology scientists have once again used data from the James Webb Space Telescope (JWST) as part of the Cosmic Evolution Early Release Science (CEERS) Survey to change the way we think about the universe and its distant galaxies.
Jeyhan Kartaltepe, associate professor in the School of Physics and Astronomy, and Rebecca Larson, postdoctoral research associate, co-authored a paper, “Confirmation and refutation of very luminous galaxies in the early Universe,” published in Nature confirming ...
Researchers from Western and Brown University have made groundbreaking progress towards identifying the root cause and potential therapy for preeclampsia.
The pregnancy complication affects up to eight per cent of pregnancies globally and is the leading cause of maternal and fetal mortality due to premature delivery, complications with the placenta and lack of oxygen.
The research, led by Drs. Kun Ping Lu and Xiao Zhen Zhou at Western, and Drs. Surendra Sharma and Sukanta Jash at Brown, has identified ...
WASHINGTON (September 15, 2023) – As misinformation flourished online during the Covid-19 pandemic, a number of platforms announced policies and practices aimed at combating the spread of misinformation. Did those efforts work?
New research published today in Science Advances suggests that the Covid-19 vaccine misinformation policies of Facebook, the world’s largest social media platform, were not effective in combating misinformation. The study, led by researchers at the George Washington University, found that Facebook’s efforts were undermined by the core design features ...
LAST 30 PRESS RELEASES:
[Press-News.org] New perspectives on MAFLD