(Press-News.org) Colorectal cancer (CRC) with synchronous peritoneal metastases (SPM) is a challenging disease to treat, with a relatively poor prognosis. However, recent advances in treatment strategies have led to improved outcomes for patients with SPM.
The optimal treatment approach for CRC with SPM remains controversial. A growing body of evidence suggests that comprehensive treatment, including cytoreductive surgery (CRS), chemotherapy, and hyperthermic intraperitoneal chemotherapy (HIPEC), may improve patient outcomes.
A recent study from China, published in the journal eGastroenterology, evaluated the treatment strategies and clinical outcomes of patients with CRC with SPM. The study included a large sample of patients and the findings suggest that comprehensive treatment was associated with a significantly improved prognosis.
Specifically, patients who underwent CRS, chemotherapy, and HIPEC had a median overall survival of 29 months, compared to 14 months for patients who received less aggressive treatment. The study also found that complete cytoreductive surgery (CC-0), in which all visible cancer is removed during CRS, was an independent predictor of improved survival.
The findings of this study are significant because they provide further evidence to support the use of comprehensive treatment for patients with CRC with SPM. The study also highlights the importance of CC-0 in achieving long-term survival benefits.
However, it is important to note that this study was observational and cannot establish a causal relationship between treatment and outcome. More refined stratification and randomized clinical trials are needed to address potential confounding factors and bias.
The study also noted that current knowledge on the treatment and prognosis of CRC with SPM is inconclusive, and a study with a large sample size from China is still lacking.
This is supported by the fact that most studies on the treatment and prognosis of patients with colorectal SPM have been conducted in Europe and North America, with limited data available from China. Additionally, the optimal treatment approach for CRC with SPM remains controversial.
The researchers also highlighted that the National Comprehensive Cancer Network (NCCN) guideline is conservative regarding CRS plus HIPEC, and clinicians still tend to favor palliative care for patients with CRC with peritoneal metastases.
Overall, the findings of this study suggest that patients with CRC with SPM who receive integrated treatment have better prognoses. Specifically, CC-0 should be considered to achieve long-term survival benefits. However, more research is needed to refine treatment strategies and identify the optimal treatment approach for all patients with CRC with SPM.
See the article:
Qin X, Yang Z, Li Y, et al. Treatment and prognosis of colorectal cancer with synchronous peritoneal metastases: 11-year single institute experience. eGastroenterology 2023; 1:e100016. doi:10.1136/egastro-2023-100016
About the eGastroenterology
eGastroenterology is a new, open-access, and open peer-reviewed BMJ Journal, which focuses on basic, clinical, translational, and evidence-based medicine research in all areas of gastroenterology (including hepatology, pancreatology, esophagology, and gastrointestinal surgery).
For more information, please visit: egastroenterology.bmj.com and follow us on Twitter (@eGastro_BMJ).
END
In a groundbreaking review published in Nature Energy, Professor Jaephil Cho from the School of Energy and Chemical Engineering at UNIST presents an analysis protocol to evaluate silicon cathode materials applicable to commercialized batteries. The study delves deep into the characteristics and challenges surrounding silicon anode materials—the focus of significant attention as secondary battery components.
Silicon has emerged as a promising alternative to conventional graphite anodes in high-energy lithium-ion batteries due to its exceptional gravimetric capacity. However, intrinsic issues such as severe volume expansion during cycling have hindered the widespread ...
Two Mount Sinai Health System hospitals are among the top-ranked for “America’s Best Physical Rehabilitation Centers for 2023” by Newsweek/Statista.
The Mount Sinai Hospital is ranked No. 2 in New York State for inpatient rehabilitation care, with stroke care designated as a “Standout Program.” Mount Sinai Morningside, on Manhattan’s Upper West Side, is ranked No. 5 for inpatient rehabilitation. These prestigious accolades highlight the exceptional quality of care and follow-up care, along with accommodations and amenities that are part of the rehabilitation ...
COLUMBUS, Ohio – In lonely people, the boundary between real friends and favorite fictional characters gets blurred in the part of the brain that is active when thinking about others, a new study found.
Researchers scanned the brains of people who were fans of “Game of Thrones” while they thought about various characters in the show and about their real friends. All participants had taken a test measuring loneliness.
The difference between those who scored highest on loneliness and those who ...
A majority of older adults disagree with the idea of using life expectancy as part of guidelines that say which patients should get cancer screenings such as mammograms and colonoscopies, a new poll finds.
In all, 62% of people aged 50 to 80 said that national guidelines for stopping cancer-detecting tests in individual patients should not be based on how long that person might have left to live, according to new results from the University of Michigan National Poll on Healthy Aging.
That goes against a trend in such guidelines, which national organizations develop based on medical evidence. Guidelines ...
PULLMAN, Wash. – Elk treponeme-associated hoof disease, previously thought to be limited to deformations in elks’ hooves, appears to create molecular changes throughout the animal’s system, according to epigenetic research from Washington State University.
The findings, published in the journal Scientific Reports, also suggest those changes may be heritable. It remains to be seen though whether this means subsequent generations of elk may be more, or less, prone to catching the devastating disease that severely impairs the elk’s ability to find food and escape predators.
“It’s not just the ...
A lack of sleep and reduced physical activity during pregnancy are linked to risk of preterm birth, according to new research led by the Stanford School of Medicine.
In the study, which will publish online Sept. 28 in npj Digital Medicine, the researchers collected data from devices worn by more than 1,000 women throughout pregnancy. With a machine learning algorithm, the scientists sifted through participants’ activity information to detect fine-grained changes in sleep and physical activity patterns.
“We showed that an artificial intelligence algorithm can build a ‘clock’ of physical activity and sleep ...
(Memphis, Tenn – September 28, 2023) Many cancers are caused by fusion oncoproteins, molecules that aberrantly form when a rearrangement of DNA results in parts of two different proteins being expressed as one. Several fusion oncoproteins spontaneously form condensates inside cells that promote cancer development. New research by St. Jude Children’s Research Hospital established a method to study this biophysical process in cells, then used that information as a launchpad to predict the behavior of other fusion oncoproteins. The findings, which offer insight into ...
An international team of scientists from Sweden, Norway, Japan, and Switzerland, has presented research findings that reveal a crucial role of biological particles, including pollen, spores, and bacteria, in the formation of ice within Arctic clouds. These findings, published today in Nature Communications, have far-reaching implications for climate science and our understanding of the rapidly changing Arctic climate.
The research, whose outcomes have unveiled the connection between biological particles and the formation of ...
Fitness and Staving Off Weight Gain May Be More Important than Weight Loss for Preventing Kidney Disease in Obese Adults, Drexel Study Says
As obesity is a contributing factor to chronic kidney disease, weight loss can help mitigate a patient’s risk. But new research suggests that fitness and preventing weight gain could actually play a more important role in reducing risk than weight loss. The findings were published today in the journal Obesity from researchers at Drexel University’s College of Medicine and Dornsife School of Public Health.
The researchers followed 1,208 overweight ...
Previous research shows that conversational turns (interactive conversations) between parents and children are important for a child’s long-term language development and academic achievement and that these conversations can be enhanced via parent-coaching language interventions. The neural networks responsible for language develop rapidly even before a child can talk, making these interactive conversations especially important during infancy.
Music is an engaging and social experience between parents and children that is often part of daily routines during infancy. Emerging literature also documents links between music experiences and child language outcomes. Researchers ...
