PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin

New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin
2023-10-04
(Press-News.org) WINSTON-SALEM, NC – October 4, 2023  - A research paper published today in Science Translational Medicine presents a significant breakthrough in the area of skin regeneration and wound healing by researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM). The study, titled "Bioprinted Skin with Multiple Cell Types Promotes Skin Regeneration, Vascularization, and Epidermal Rete Ridge Formation in Full-Thickness Wounds," shows the successful development of bioprinted skin that accelerate wound healing, support healthy extracellular matrix remodeling, and provide optimism for complete wound recovery. Anthony Atala, M.D., director of WFIRM and Adam Jorgensen, M.D., Ph.D., post-doctorate researcher at WFIRM, co-led the study.

Skin regeneration has long been studied with hopes of providing burn victims, wounded warriors, and those with skin disorders opportunities at complete healing. Available grafts are often temporary, or if permanent, have only some of the elements of normal skin, which often have a scarred appearance. The creation of full thickness skin has not been possible to date. This study involved the bioprinting of all six major primary human cell types present in skin combined with specialized hydrogels as a bioink. Multi-layered full thickness skin was created which contained all three layers present in normal human tissue: epidermis, dermis, and hypodermis. When transplanted in pre-clinical settings, the bioprinted skin formed blood vessels, skin patterns, and normal tissue formation. Additional arms of the study demonstrated improved wound closure, reduced skin contraction, and more collagen production to reduce scarring.

“Comprehensive skin healing is a significant clinical challenge, affecting millions of individuals worldwide, with limited options,” explained Dr. Atala, who is the primary author on the paper. “These results show that the creation of full thickness human bioengineered skin is possible, and promotes quicker healing and more naturally appearing outcomes.”

By leveraging existing bioprinting technology to address these limitations, the team at WFIRM has proven that fully functional skin regeneration is possible. The bioengineered skin grafts offer a triple-layer structure for full-thickness wound coverage.

In addition to Atala and Jorgensen, the research team includes Anastasiya Gorkun, Ph.D., Naresh Mahajan, Ph.D., Kelsey Willson, Ph.D., Cara Clouse, D.V.M., Claire G. Jeong, Mathew Varkey, Ph.D., Mingsong Wu, Stephen J. Walker, Ph.D., Joseph A. Molnar, M.D., Ph.D., Sean V. Murphy, Ph.D., Sang Jin Lee, Ph.D., James J Yoo, M.D., Ph.D., and Shay Soker, Ph.D., all of Wake Forest University School of Medicine. The full research paper, "Bioprinted Skin with Multiple Cell Types Promotes Skin Regeneration, Vascularization, and Epidermal Rete Ridge Formation in Full-Thickness Wounds," is available for review in the October issue of Science Translational Medicine, a leading peer-reviewed journal that publishes cutting-edge research with the potential to transform clinical practice and improve patient care.

About the Wake Forest Institute for Regenerative Medicine: The Wake Forest Institute for Regenerative Medicine is recognized as an international leader in translating scientific discovery into clinical therapies, with many world firsts, including the development and implantation of the first engineered organ in a patient. Over 450 people at the institute, the largest in the world, work on more than 40 different tissues and organs. A number of the basic principles of tissue engineering and regenerative medicine were first developed at the institute. WFIRM researchers have successfully engineered replacement tissues and organs in all four categories – flat structures, tubular tissues, hollow organs and solid organs – and 16 different applications of cell/tissue therapy technologies, such as skin, urethras, cartilage, bladders, muscle, kidney, and vaginal organs, have been successfully used in human patients. The institute, which is part of Wake Forest University School of Medicine, is located in the Innovation Quarter in downtown Winston-Salem, NC, and is driven by the urgent needs of patients. The institute is making a global difference in regenerative medicine through collaborations with over 500 entities and institutions worldwide, through its government, academic and industry partnerships, its start-up entities, and through major initiatives in breakthrough technologies, such as tissue engineering, cell therapies, diagnostics, drug discovery, biomanufacturing, nanotechnology, gene editing and 3D printing. 

Media Contact: Emily Gregg, egregg@wakehealth.edu

END

[Attachments] See images for this press release:
New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin 2 New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin 3

ELSE PRESS RELEASES FROM THIS DATE:

Analysis of grinding tools reveals plant, pigment and bone processing in Neolithic Northern Saudi Arabia

Analysis of grinding tools reveals plant, pigment and bone processing in Neolithic Northern Saudi Arabia
2023-10-04
In recent years, studies have revealed that the now-arid region of northern Arabia was once much wetter and greener, providing Neolithic human populations with access to both water and game. The present aridity of the region, however, preserves little organic matter, making a reconstruction of the Neolithic lifestyle difficult. Now, in a new study published in the journal PLOS ONE, researchers from the Max Planck Institute of Geoanthropology, the National Research Council of Italy, Institute of Heritage Science (CNR ISPC), and University College London present use-wear ...

Early human migrants followed lush corridor-route out of Africa

Early human migrants followed lush corridor-route out of Africa
2023-10-04
An international team of scientists has found early human migrants left Africa for Eurasia, across the Sinai peninsula and on through Jordan, over 80-thousand years ago. Researchers from the University of Southampton (UK) and Shantou University (China), together with colleagues in Jordan, Australia and the Czech Republic(1), have proved there was a “well-watered corridor” which funnelled hunter-gatherers through The Levant towards western Asia and northern Arabia via Jordan. Their findings, published in the journal Science Advances, support previous research conducted ...

A UCLA-led team may have found the key to stimulating human brown adipose tissue into combating obesity

2023-10-04
EMBARGOED FOR USE UNTIL: 2 p.m. (ET) on Oct. 4, 2023 -- A UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue (BAT), a type of tissue that releases chemical energy from fat metabolism as heat – a finding that could pave the way toward using it to treat obesity and related metabolic conditions. The researchers have for the first time detailed this nerve supply and provided examples of how manipulating it can change BAT activity, marking a first step toward understanding how to use it therapeutically, said ...

Proteins roll the dice to determine bee sex

Proteins roll the dice to determine bee sex
2023-10-04
To date it has been unclear exactly how the sex of a bee is determined. A research team from Heinrich Heine University Düsseldorf (HHU) comprising biologists and chemists has now identified a key gene and the molecular mechanism linked with it. In the current issue of the scientific journal Science Advances, they describe how this process is similar to a game involving two dice. The sex of a living creature has significant consequences for its form, function and behaviour. The biological sex of an organism is usually determined at the start of its life. In humans, for example, the presence of the sex-determining “Y chromosome” ...

DOE’s Office of Science Graduate Student Research (SCGSR) Program selects 60 outstanding U.S. graduate students

2023-10-04
WASHINGTON, DC – The Department of Energy’s (DOE’s) Office of Science has selected 60 graduate students representing 26 states for the Office of Science Graduate Student Research (SCGSR) program’s 2023 Solicitation 1 cycle. Through world-class training and access to state-of-the-art facilities and resources at DOE National Laboratories, SCGSR prepares graduate students to enter jobs of critical importance to the DOE mission and secures our national position at the forefront of discovery and innovation. “This ...

Brain & Behavior Research Foundation names Special Olympics International Recipient of 2023 Pardes Humanitarian Prize in Mental Health and awards Honorary Pardes Prize to Henry Jarecki, M.D

Brain & Behavior Research Foundation names Special Olympics International Recipient of 2023 Pardes Humanitarian Prize in Mental Health and awards Honorary Pardes Prize to Henry Jarecki, M.D
2023-10-04
NEW YORK (October 4, 2023) -- The Brain & Behavior Research Foundation today announced that Special Olympics International is the recipient of the 2023 Pardes Humanitarian Prize in Mental Health. It is recognized for its lasting humanitarian impact around the world through sports training and athletic competition for adults and children with intellectual disabilities. An Honorary Pardes Prize Recipient was also announced for 2023 – Henry Jarecki, M.D – for his important contributions to the field of psychiatry and his unique work to preserve academic and scientific freedom. “Special Olympics International is being honored as a beacon of light ...

Mayo Clinic researchers develop calculation to identify high-risk moderate aortic stenosis patients

2023-10-04
ROCHESTER, Minn. — Mayo Clinic researchers have developed a calculation that can help identify moderate aortic stenosis patients at higher risk of dying from the condition. According to new research published in Mayo Clinic Proceedings, calculating the patient's mean arterial pressure (AugMAP) is a simple and effective way to identify those patients who may benefit from more aggressive treatment strategies. "Physiologically, AugMAP can be considered a marker of global left ventricular contractile function," says Chieh-Ju Chao, M.D., senior associate consultant in the Mayo Clinic Department ...

Machine learning used to probe the building blocks of shapes

Machine learning used to probe the building blocks of shapes
2023-10-04
Applying machine learning to find the properties of atomic pieces of geometry shows how AI has the power to accelerate discoveries in maths. Mathematicians from Imperial College London and the University of Nottingham have, for the first time, used machine learning to expand and accelerate work identifying ‘atomic shapes’ that form the basic pieces of geometry in higher dimensions. Their findings have been published in Nature Communications. The way they used artificial intelligence, in the form of machine learning, could transform how maths is done, say the authors. Dr Alexander Kasprzyk from ...

Invertebrate biodiversity is improving in England’s rivers, long-term trends show

2023-10-04
Rivers across England have seen a significant improvement in river invertebrate biodiversity since 1989, shows a study led by UK Centre for Ecology & Hydrology (UKCEH) researchers. The study, which involved one of the largest and most wide-ranging analyses of long-term monitoring data in the world – spanning over 30 years, found improvements in invertebrate biodiversity across all regions and river types in England. This improvement is all the more surprising given English rivers are amongst the most highly exposed to wastewater and other pressures in Europe. The recent State of Nature report shows that the overall abundance of species in Great ...

LSU Health New Orleans’ Porche awarded top honor by National League for Nursing

LSU Health New Orleans’ Porche awarded top honor by National League for Nursing
2023-10-04
New Orleans – The National League for Nursing (NLN) presented Demetrius Porche, DNS, PhD, ANEF, FACHE, FAANP, FAAN, Professor and Dean of LSU Health New Orleans School of Nursing, with its Mary Adelaide Nutting Award for Outstanding Teaching or Leadership in Nursing Education during the 2023 NLN Education Summit. The Annual NLN Awards recognize and honor individuals of stature and distinction for their outstanding contributions to nursing education and the broader space of health care. The NLN Mary Adelaide ...

LAST 30 PRESS RELEASES:

Reality check: making indoor smartphone-based augmented reality work

Overthinking what you said? It’s your ‘lizard brain’ talking to newer, advanced parts of your brain

Black men — including transit workers — are targets for aggression on public transportation, study shows

Troubling spike in severe pregnancy-related complications for all ages in Illinois

Alcohol use identified by UTHealth Houston researchers as most common predictor of escalated cannabis vaping among youths in Texas

Need a landing pad for helicopter parenting? Frame tasks as learning

New MUSC Hollings Cancer Center research shows how Golgi stress affects T-cells' tumor-fighting ability

#16to365: New resources for year-round activism to end gender-based violence and strengthen bodily autonomy for all

Earliest fish-trapping facility in Central America discovered in Maya lowlands

São Paulo to host School on Disordered Systems

New insights into sleep uncover key mechanisms related to cognitive function

USC announces strategic collaboration with Autobahn Labs to accelerate drug discovery

Detroit health professionals urge the community to act and address the dangers of antimicrobial resistance

3D-printing advance mitigates three defects simultaneously for failure-free metal parts 

Ancient hot water on Mars points to habitable past: Curtin study

In Patagonia, more snow could protect glaciers from melt — but only if we curb greenhouse gas emissions soon

Simplicity is key to understanding and achieving goals

Caste differentiation in ants

Nutrition that aligns with guidelines during pregnancy may be associated with better infant growth outcomes, NIH study finds

New technology points to unexpected uses for snoRNA

Racial and ethnic variation in survival in early-onset colorectal cancer

Disparities by race and urbanicity in online health care facility reviews

Exploring factors affecting workers' acquisition of exercise habits using machine learning approaches

Nano-patterned copper oxide sensor for ultra-low hydrogen detection

Maintaining bridge safer; Digital sensing-based monitoring system

A novel approach for the composition design of high-entropy fluorite oxides with low thermal conductivity

A groundbreaking new approach to treating chronic abdominal pain

ECOG-ACRIN appoints seven researchers to scientific committee leadership positions

New model of neuronal circuit provides insight on eye movement

Cooking up a breakthrough: Penn engineers refine lipid nanoparticles for better mRNA therapies

[Press-News.org] New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin