(Press-News.org) A groundbreaking study recently published in JAMA indicates that aspirin may not be necessary as part of an antithrombotic regimen for patients with a fully magnetically levitated left ventricular assist device (LVAD). Ochsner Health surgical director for the Mechanical Assist Device Circulatory Support Program, Dr. Aditya Bansal, was a contributing author on the study known as the ARIES-HM3 trial.
The ARIES-HM3 trial, a randomized trial involving 628 patients with advanced heart failure, compared the outcomes of patients who received aspirin (100 mg/d) with those who received a placebo in addition to a vitamin K antagonist (VKA) therapy. The trial was conducted across 51 centers in 9 countries, with patients enrolled from July 2020 to September 2022.
Dr. Bansal said, “LVADs have transformed the treatment of advanced heart failure; however, nonsurgical bleeding events remain a significant concern. We have commonly used aspirin as an antiplatelet agent alongside VKAs with continuous-flow LVADs, even though there has been limited evidence of its efficacy and safety. This study has demonstrated that excluding aspirin from the treatment plan resulted in a significant decrease (34%) in major nonsurgical bleeding events without increasing the risk of thromboembolic complications.”
The results of the study were remarkable. Patients who did not receive aspirin had a higher rate of survival free from major nonsurgical hemocompatibility-related adverse events at 12 months compared to those who took aspirin. Furthermore, avoiding aspirin was associated with a significant reduction in nonsurgical bleeding events, without an increase in stroke or other thromboembolic events.
This study challenges the conventional approach and provides compelling evidence that excluding aspirin from the antithrombotic regimen is not only safe but also beneficial in reducing bleeding events. Researchers conclude that in patients with advanced heart failure treated with a fully magnetically levitated LVAD, avoiding aspirin as part of the antithrombotic regimen, which includes VKA, is not inferior to a regimen containing aspirin.
Dr. Bansal shared, “the results of the ARIES-HM3 trial have the potential to transform clinical practice and improve outcomes for patients with advanced heart failure. This is an exciting development as we continue to refine best practices for treating heart failure patients.”
END
Ochsner participates in study showing aspirin may not be necessary with LVAD
2023-11-21
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Caring is sharing: Call for more openness on cancer drug trial results
2023-11-21
Development of potential or improved anti-cancer treatments are being blocked or slowed down by lack of transparency in data sharing between pharmaceutical companies and research groups, according to cancer clinicians, researchers and consumers.
The multidisciplinary team led by Flinders University researchers Mr Natansh Modi and Dr Ashley Hopkins evaluates the literature and policy developments since the 2013 data sharing commitments were struck by US and European regulators, including the commitment to publish clinical trial results.
The agreement forged by the Pharmaceutical Research and Manufacturers ...
Calls for improved support about menstruation changes during perimenopause
2023-11-21
Perimenopausal women need better education and support about how their periods might change towards the end of their reproductive life, finds a new study led by UCL researchers.
The research, published in Post Reproductive Health, highlighted how as women approach the menopause, their periods may become unpredictable, heavy and cause worse premenstrual symptoms – including mood swings, breast tenderness and headaches.
The team of researchers from the UCL EGA Institute of Women’s Health and Centre for Reproductive Health, University of Edinburgh, ...
Why emotions stirred by music create such powerful memories
2023-11-20
Key takeaways
UCLA psychologists used music to manipulate emotions of volunteers and found the dynamics of their emotions molded otherwise neutral experiences into memorable events.
The tug of war between integrating memories and separating them helps to form distinct memories, allowing people to understand and find meaning in their experiences, and retain information.
These findings could hold therapeutic promise in helping people with PTSD and depression.
Time flows in a continuous stream — yet our ...
Low-quality studies on early interventions for autism dominate the field, says researchers
2023-11-20
CHAPEL HILL, N.C. – The Centers for Disease Control and Prevention report that autism is becoming more common in young children. In an effort to improve the challenges young autistic children face as part of their early development, researchers have focused on developing and evaluating nonpharmaceutical interventions that can be provided in early childhood.
Micheal Sandbank, PhD, an assistant professor in the Department of Health Sciences at the UNC School of Medicine, is an expert on the research supporting these early interventions, which informs clinical practice across the United States. A new comprehensive meta-analysis, led by Sandbank, shows that many low-quality ...
Study finds possible early predictor of successful transcranial magnetic stimulation therapy for major depression
2023-11-20
A new study from UCLA Health researchers demonstrates that a novel treatment is effective in most patients with major depressive symptoms even after multiple failed courses of antidepressant medication. The treatment, repetitive transcranial magnetic stimulation (rTMS), may work even more rapidly than past findings have suggested, starting to alleviate symptoms as quickly as one week.
Researchers from the Neuromodulation Division of UCLA’s Semel Institute analyzed the outcomes of hundreds of patients treated at UCLA Health from 2009 to 2022 with rTMS therapy, which uses magnetic fields to effectively “rewire” ...
Trend report: High blood pressure increasing in low-income adults; diabetes and obesity on the rise in higher-income adults
2023-11-20
Embargoed for release until 5:00 p.m. ET on Monday 20 November 2023
Annals of Internal Medicine Tip Sheet
@Annalsofim
Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.
----------------------------
1. ...
More than 1,100 physicians, health care professionals, and scientists boycott medical journal
2023-11-20
WASHINGTON, D.C. — More than 1,100 experts have joined the Physicians Committee for Responsible Medicine in boycotting the medical journal Nutrients until it stops publishing egregious animal experiments that could have been ethically conducted in humans.
The boycott, which also applies to Nutrients’ publisher, MDPI, comes after repeated requests to the journal’s editors asking them to institute sound editorial practices.
A letter sent to those editors today, Nov. 20, 2023, says “As a community of scientists and health care professionals, we have ...
Urban environmental exposures drive increased breast cancer incidence
2023-11-20
DURHAM, N.C. – A Duke Health analysis of breast cancer in North Carolina showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis.
The findings, appearing in the journal Scientific Reports, serve as a national template for assessing the impact of poor environmental quality across different stages of breast cancer, which is marked by highly diverse origins and mechanisms for spreading. North Carolina serves as a good model; it has a diverse population ...
C-sections in Mexico increase with obesity level and health care specialization
2023-11-20
URBANA, Ill. — Cesarean section (C-section) procedures have increased dramatically around the world in the recent decades. Overweight and obesity rates, common risk factors for pregnancy outcomes and for C-sections, are also on the rise — creating a major health issue in low- and middle-income countries. A new study from the University of Illinois Urbana-Champaign investigates how high obesity levels lead to hospital specializations that affect the frequency of C-sections in Mexico.
“Of course, obesity is a medical factor for C-sections; however, when we started this project we did not believe it to be the ...
New machine learning technique 30% better at predicting cancer cure rates
2023-11-20
With the rapid development in computing power over the past few decades, machine-learning (ML) techniques have become popular in medical settings as a way to predict survival rates and life expectancies among patients diagnosed with diseases such as cancer, heart disease, stroke, and, more recently, COVID-19. Such statistical modeling helps patients and caregivers balance treatment that offers the highest chance of a cure while minimizing the consequences of potential side effects.
A professor and his doctoral student at The University of Texas at Arlington have published a new model of predicting survival from ...