Evolving insights in blood-based liquid biopsies for prostate cancer interrogation
2023-12-08
(Press-News.org)
“In the United States, 288,300 new cases of prostate cancer are estimated for 2023 [...]”
BUFFALO, NY- December 8, 2023 – A new research perspective was published in Oncoscience (Volume 10) on November 30, 2023, entitled, “Evolving insights in blood-based liquid biopsies for prostate cancer interrogation.”
During the last decade, blood sampling of cancer patients aimed at analyzing the presence of cells, membrane-bound vesicles, or molecules released by primary tumors or metastatic growths emerged as an alternative to traditional tissue biopsies. The advent of this minimally invasive approach, known as blood-based liquid biopsy, began to play a pivotal role in the management of diverse cancers, establishing itself as a vital component of precision medicine.
In this new paper, researchers R. Daniel Bonfil and Ghaith Al-Eyd from Nova Southeastern University discuss three blood-based liquid biopsies, namely circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumor-derived exosomes, as they relate to prostate cancer (PCa) management.
“In this research perspective, we present a comprehensive overview of the recent advances related to the clinical significance of blood-based liquid biopsies in PCa, with a primary emphasis placed on key biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and exosomes.”
The advances achieved in the molecular characterization of these types of liquid biopsies and their potential to predict recurrence, improve responses to certain treatments, and evaluate prognosis, in PCa patients, are highlighted herein. While there is currently full clinical validation for only one CTC-based and one ctDNA-based liquid biopsy for patients with metastatic castration-resistant PCa, the adoption of additional methods is anticipated as they undergo standardization and achieve analytical and clinical validation. Advantages and disadvantages of different blood-based liquid biopsy approaches in the context of PCa are outlined in this paper, while also considering potential synergies through combinatory strategies.
“We anticipate that, with the assistance of artificial intelligence based on pre-established parameters, the utilization of blood-based liquid biopsies will soon enhance the stratification of PCa patients and facilitate timely therapeutic decision making.”
Read the full paper: DOI: https://doi.org/10.18632/oncoscience.592
Correspondence to: R. Daniel Bonfil
Email: rbonfil@nova.edu
Keywords: prostate cancer, liquid biopsy, circulating tumor cells (CTC), circulating tumor DNA (ctDNA), exosomes
About Oncoscience:
Oncoscience is a peer-reviewed, open-access, traditional journal covering the rapidly growing field of cancer research, especially emergent topics not currently covered by other journals. This journal has a special mission: Freeing oncology from publication cost. It is free for the readers and the authors.
To learn more about Oncoscience, visit Oncoscience.us and connect with us on social media:
X, formerly known as Twitter
Facebook
YouTube
LinkedIn
For media inquiries, please contact media@impactjournals.com.
Oncoscience Journal Office
6666 East Quaker Str., Suite 1D
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 4
###
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2023-12-08
The most durable, heat-resistant materials ever made could be hiding in plain sight.
The U.S. Department of Defense wants to know if minerals and rocks found on Earth and in space hold the secrets of next-generation high-temperature materials. To find out, the DOD awarded $6.25 million through its Multidisciplinary University Research Initiative, or MURI, to a team from the University of Virginia and Arizona State University. The group is led by UVA’s Elizabeth J. Opila, the Rolls-Royce Commonwealth Professor and chair of the Department of Materials Science and Engineering.
The ...
2023-12-08
Magnesium oxide is a promising material for capturing carbon dioxide directly from the atmosphere and injecting it deep underground to limit the effects of climate change. But making the method economical will require discovering the speed at which carbon dioxide is absorbed and how environmental conditions affect the chemical reactions involved.
Scientists at the Department of Energy’s Oak Ridge National Laboratory analyzed a set of magnesium oxide crystal samples exposed to the atmosphere for decades, and another for days to months, to gauge the reaction rates. They found that carbon ...
2023-12-08
A study looking at 15 years of HIV transmission and suppression in Uganda reveals how closing gender gaps in treatment could slash infection rates.
Providing more heterosexual men with easy access to HIV treatment and care could help to suppress the virus and rapidly cut transmission to their female partners, shows a new study published in Nature Microbiology.
The research, led by scientists from Imperial College London and the Rakai Health Sciences Program in Uganda, analysed 15 years of data from 2003-2018, during which the US President’s Emergency Plan For AIDS ...
2023-12-08
When Senior Scientist Jonathan Grimm came to Janelia 13 years ago, he didn’t know much about fluorescence or fluorescent dyes. But as an organic chemist who had been working in drug discovery at Merck, he certainly knew a thing or two about medicinal chemistry.
On a whim, Grimm and Janelia Senior Group Leader Luke Lavis decided to try using a mainstay medicinal chemistry reaction Grimm had picked up in the pharmaceutical industry to improve centuries-old dye chemistry. They thought this approach could allow access to completely new, previously inaccessible rhodamines – molecules Lavis had been working to make brighter and longer-lasting so they could be ...
2023-12-08
The Gerontological Society of America (GSA) — the country’s largest interdisciplinary organization devoted to the field of aging — is proud to acknowledge the work of 34 outstanding individuals through its prestigious awards program.
GSA salutes outstanding research, recognizes distinguished leadership in teaching and service, and fosters new ideas through a host of awards. Nominated by their peers, the recipients’ achievements serve as milestones in the history and development of ...
2023-12-08
Nuclear fusion, the process that powers the sun, is the ultimate source of energy for all life on Earth. On the sun, deuterium and tritium nuclei combine to produce an alpha particle (the nucleus of a helium atom) and a neutron. The dream is to do the same down here, on Earth, in a controlled manner.
It’s for good reason that harnessing fusion energy is one of the greatest scientific and technological challenges of the 21st century. Fusion requires the fuel to be heated to more than 100 million degrees (10 times hotter than the core of the sun). Practical fusion energy also requires that the burning fuel is kept at these hot temperatures long enough so that energy ...
2023-12-08
More than 1.2 million people have died in the United States during the COVID-19 pandemic to date, more documented deaths than any other nation on Earth.
While many have attributed the high death toll on widespread personal hesitancy to wear masks, avoid crowded places or receive vaccines once they were developed, there were several “system hesitancies” that contributed to the tragic outcomes that need addressing, according to an analysis published Dec. 6, 2023, in Health Affairs Forefront.
The analysis ...
2023-12-08
LOS ANGELES – December 8, 2023 – Stand Up To Cancer® (SU2C) today announced the appointment of Julian Adams, Ph.D., as president and chief executive officer, which will be effective on January 1, 2024. Adams had previously served on SU2C’s Scientific Advisory Committee since 2008, and officially joined SU2C in July 2023 in the newly created position of chief science officer. He succeeds Russell Chew, who joins SU2C’s Board of Directors.
Adams is a longtime oncology researcher and pharmaceutical industry senior executive specializing in drug discovery and development in cancer. With this appointment, Adams assumes management responsibility for SU2C’s overall ...
2023-12-08
Northwestern University researchers have developed new virtual reality (VR) goggles for mice.
Besides just being cute, these miniature goggles provide more immersive experiences for mice living in laboratory settings. By more faithfully simulating natural environments, the researchers can more accurately and precisely study the neural circuitry that underlies behavior.
Compared to current state-of-the-art systems, which simply surround mice with computer or projection screens, the new goggles provide a leap in advancement. In current systems, mice can still see the lab environment peeking out from behind the screens, and the screens’ ...
2023-12-08
About The Study: In this study, in both Medicaid only and dual-eligible populations, Hispanic and non-Hispanic Black individuals had the lowest odds of receiving hospice, and Hispanic individuals had the highest odds of a short hospice stay. Knowledge about, access to, and acceptance of hospice may be lacking for these low-income individuals. Further research is needed to understand barriers to and facilitators of hospice use for people with nursing facility stays.
Authors: Julie ...
LAST 30 PRESS RELEASES:
[Press-News.org] Evolving insights in blood-based liquid biopsies for prostate cancer interrogation
