(Press-News.org)
A new review paper was published in Oncotarget's Volume 14 on December 12, 2023, entitled, “Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in Brazil: Balancing efficacy, safety, and tolerability.”
Classic Hodgkin lymphoma (CHL), which accounts for 90–95% of all cases of Hodgkin lymphoma, is the most frequent cancer in adolescents and the most frequent lymphoma in adolescents and young adults. Despite progressive improvements over past decades and the general sensitivity of CHL to frontline chemotherapy, approximately 10–15% of patients have refractory disease that either does not respond to such therapy or progresses after an initial partial response.
In patients with refractory or relapsed disease, standard treatment until recently consisted mainly of salvage chemotherapy, in many cases followed by high-dose chemotherapy and autologous stem-cell transplantation. However, improved understanding of the pathobiology of CHL, coupled with the introduction of novel agents, has markedly changed the treatment landscape in the past decade. Although refractory or relapsed CHL continues to be challenging, the therapeutic landscape is undergoing profound changes brought about by novel agents, particularly brentuximab vedotin and immunotherapy.
In this new review, researchers Flávia Dias Xavier, Danielle Leão Cordeiro de Farias, Abrahão Elias Hallack Neto, Glaciano Nogueira Ribeiro, Marco Aurelio Salvino de Araujo, Thiago Xavier Carneiro, and Otavio Cesar Carvalho Guimarães Baiocchi from Hospital Universitário de Brasília-Universidade de Brasília/Ebserh, Hospital DF Star, Hospital A Beneficência Portuguesa de São Paulo, Universidade Federal de Juiz de Fora, Clínica Hematológica/Grupo Oncoclinicas, Universidade Federal da Bahia, Instituto D'Or de Pesquisa e Ensino, Universidade Estadual do Pará, Universidade Federal de São Paulo, and Hospital Alemão Oswaldo Cruz discuss the most salient treatment options for adult patients with refractory or relapsed CHL, with a special focus on the Brazilian healthcare setting, which is constrained by inherent characteristics of this system.
“In the attempt to balance efficacy, safety and tolerability, practicing physicians must rely on clinical trials and on results from real-world studies, and use their own point of view and experience, as well as patient characteristics and previous therapy, to make treatment decisions for refractory or relapsed CHL.”
Read the full paper: DOI: https://doi.org/10.18632/oncotarget.28541
Correspondence to: Flávia Dias Xavier
Email: flavia.xavier@unb.br
Keywords: brentuximab vedotin, drug therapy, hodgkin lymphoma, nivolumab, pembrolizumab
About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
X, formerly known as Twitter
Facebook
YouTube
Instagram
LinkedIn
Pinterest
LabTube
Soundcloud
Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28541
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact: media@impactjournals.com.
Oncotarget Journal Office
6666 East Quaker Str., Suite 1A
Orchard Park, NY 14127
Phone: 1-800-922-0957 (option 2)
###
END
Young adults who are more familiar with e-cigarette marketing practices are more likely to have attitudes against vaping than those unaware of the industry’s marketing, according to a study led by Drexel University public health researchers published this month in the BMJ journal Tobacco Control. Expanding on ways cigarettes were marketed in the 1970s, such as using models and hosting smoking events, e-cigarette marketing includes more modern tactics, like paying social media influencers to promote vaping. The findings, from researchers at Drexel’s Dornsife School of Public Health and The National Institute ...
A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer’s disease. In a new review paper in the Journal of Internal Medicine, the lab that led those studies takes stock of what a growing number of scientists worldwide have been finding out since then in dozens of clinical and lab benchtop studies.
Brain rhythms (also called brain “waves” or ...
In a new study, viewers of Facebook users’ posts came away with perceptions of the users that differed from the users’ own self-perceptions. Qi Wang and colleagues at Cornell University, New York, US, present these findings in the open-access journal PLOS ONE on December 20, 2023.
Many people post on social media platforms in order to express themselves and connect with others. Prior research has shown that viewers of personal websites, such as blogs or online profiles, form largely accurate perceptions ...
In a survey study comparing Ukrainian refugees living in Kraków, Poland with those farther away from Ukraine in Vienna, Austria, those in Vienna tended to have higher education levels, more prior work experience, and greater willingness to remain in their new area of residence. Judith Kohlenberger of the Vienna University of Economics and Business, Austria, and colleagues present these findings in the open-access journal PLOS ONE on December 20, 2023.
Since Russia’s ongoing invasion of Ukraine began in early 2022, nearly 8 million Ukrainians have fled the country. These refugees often tend to be female, in their mid- to late 30s, and more highly educated than the average ...
Having high cholesterol and high blood pressure before the age of 55 has a lasting impact on your risk of heart disease in later life - even if you subsequently lower your levels
###
Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295004
Article Title: Association between systolic blood pressure and low-density lipoprotein cholesterol with coronary heart disease according to age
Author Countries: Australia, UK
Funding: The authors received no specific funding for this work. END ...
Women's risk of infertility increases by 3% for every extra 1cm of waist measurement, though physical activity may be protective, finds US epidemiological study
###
Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295360
Article Title: Association between waist circumference and female infertility in the United States
Author Countries: China
Funding: JK received the funding from the Science and Technology Project of Huizhou (http://sti.huizhou.gov.cn/). Grant number: 2022CZ010016. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. END ...
An international team of scientists has found the first direct evidence linking seemingly random weather systems in the ocean with climate on a global scale. Led by Hussein Aluie, an associate professor in the University of Rochester’s Department of Mechanical Engineering and staff scientist at the University’s Laboratory for Laser Energetics, the team reported their findings in Science Advances.
The ocean has weather patterns like what we experience on land, but on different time and length scales, says lead author Benjamin Storer, a research associate in Aluie’s Turbulence and Complex Flow Group. A weather pattern on land might last ...
In general, frogs’ teeth aren’t anything to write home about—they look like pointy little pinpricks lining the upper jaw. But one group of stream-dwelling frogs in Southeast Asia has a strange adaptation: two bony “fangs” jutting out of their lower jawbone. They use these fangs to battle with each other over territory and mates, and sometimes even to hunt tough-shelled prey like giant centipedes and crabs. In a new study, published in the journal PLOS ONE, researchers have described a new species of fanged frog: the smallest one ever discovered.
“This new species is tiny compared to other fanged frogs on the island where ...
COLUMBUS, Ohio – Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit. Their muscle wasting is substantial and extends beyond what can explained by inactivity or denervation (loss of nerve supply) alone.
Research led by The Ohio State University Wexner Medical Center and College of Medicine published in the journal Science Translational Medicine sheds new light and decodes early muscle loss after SCI to provide an unprecedent first understanding that muscle wasting is:
rapid ...
The world’s top fossil fuel firms subtly reset online conversations about climate change by ignoring discussions of extreme weather in favour of sharing praise for their own sustainability work, according to a new research paper in Nature’s npj | Climate Action series.
Over half a million social media posts on X (formerly Twitter) were studied using artificial intelligence-assisted language/rhetoric analysis to reveal how fossil fuel companies, intergovernmental organisations (IGOs) and non-governmental organisations (NGOs) interact online in conversations about climate change, including responses to climate change-related ...
