PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New study is one of first to show people with evidence of any remission of diabetes from weight-loss trial had a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease

2024-01-19
(Press-News.org) While several trials have shown that substantial weight loss using diet and lifestyle can reverse type 2 diabetes, new research published in Diabetologia (the journal of the European Association of the Study of Diabetes [EASD]) is among the first to show the subsequent impact of remission on cardiovascular outcomes. The study is by Professor Edward Gregg, Head of the School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland, and colleagues.

The new study shows that in patients that took part in the Look AHEAD study, those with any evidence of remission had a 40% lower rate of cardiovascular disease (CVD) and 33% lower rate of chronic kidney disease (CKD).

The Look AHEAD study was a multi-centre RCT that compared the effect of a 12-year intensive lifestyle intervention (ILI) with that of diabetes support and education (DSE) on CVD and other long-term health conditions. The study, carried out between 2001 and 2016, recruited and randomised 5145 adults with overweight or obesity (BMI >25 kg/m2 for non-insulin users or BMI >27 kg/m2 for insulin users) aged 45–76 years with type 2 diabetes. The authors conducted an observational post hoc analysis of participants in both groups, classified them based on remission status, and then compared long-term outcomes (described below) based on any remission, and the duration of remission, over a period of 12 years. They compared the incidence of CVD and CKD among more than 4000 participants, respectively, based on achievement and duration of diabetes remission.

Participants were 58% female, and had a mean age of 59 years, a mean duration of diabetes of 6 years, and a mean BMI of 35.8 kg/m2 (in the range of severe obesity). The authors applied an epidemiological definition of remission: taking no diabetes medications and having a glycated haemoglobin (HbA1c – a measure of blood sugar control) of <48 mmol/mol (6.5%) at a single point in time.

The team defined high-risk or very high-risk CKD based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria, and CVD incidence as any occurrence of non-fatal acute heart attack, stroke, admission for angina or CVD death.

Participants with evidence of any diabetes remission during follow-up had a 33% lower rate of CKD and a 40% lower rate of CVD in analyses adjusting for HbA1c, blood pressure, blood fats, CVD history, diabetes duration and intervention arm, compared to participants without remission. The magnitude of risk reduction was greatest for participants with evidence of longer-term remission.

The authors say they observed three main findings related to the implications of achieving diabetes remission. First, although 18% of participants achieved remission at some point during follow-up, the percentage of participants with current remission had decreased to 3% by the 8th year of the study, underlining the challenges of keeping weight off using lifestyle interventions. Second, despite the relatively short-lived durations of most episodes of remission, they found that any achievement of remission was associated with 33% and 40% lower rates of CKD and CVD, respectively, compared with participants who did not achieve remission, and risk reduction was even greater (55% and 49%, respectively) among those who had evidence of at least 4 years of remission (see table 2 and figure 2 of full paper)  Third, participants with a short duration of diabetes, low starting HbA1c and a large magnitude of weight loss were most likely to experience remission. The authors conclude that the associations they found “may be explained by post-baseline improvements in weight, fitness, HbA1c and LDL (bad) cholesterol.”

Professor Gregg says: “As the first intervention study to associate remission with reduction of diabetes-related complications, this is encouraging news for those who can achieve remission from type 2 diabetes. While our study is also a reminder that maintenance of weight loss and remission is difficult, our findings suggests any success with remission is associated with later health benefits.”

 

 

 

 

 

 

 

 

 

 

 

 

END


ELSE PRESS RELEASES FROM THIS DATE:

RCSI research shows new benefits of weight loss for type 2 diabetes

RCSI research shows new benefits of weight loss for type 2 diabetes
2024-01-19
18 January 2024: Researchers in the School of Population Health at RCSI University of Medicine and Health Sciences have provided new evidence of the health benefits of weight loss efforts that lead to diabetes remission for type 2 diabetes patients.   For participants in the weight-loss trial who were able to achieve remission i.e. reduce the need for medications and reduce their HbA1c levels (a measure of blood sugar control), the research found there was a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease in this group.  While previous trials have shown that substantial weight loss using diet and lifestyle can reverse type ...

Rice research opens new arena to study quantum interactions

Rice research opens new arena to study quantum interactions
2024-01-18
HOUSTON – (Jan. 18, 2024) – Quantum technologies bring the promise of faster computing, enhanced drug development and new sensing applications. However, quantum behaviors are difficult to study experimentally since most systems can only sustain quantum effects for a short time. “The reason why quantum physics’ mysterious features tend to vanish so quickly is a process called decoherence,” said Kaden Hazzard, associate professor of physics and astronomy at Rice University and a corresponding author on a study published in Nature Physics. “It occurs when a quantum system ...

For this beetle, ‘date night’ comes every other day

For this beetle, ‘date night’ comes every other day
2024-01-18
Life on Earth runs on a 24-hour cycle as the planet turns. Animals and plants have built-in circadian clocks that synchronize metabolism and behavior to this daily cycle. But one beetle is out of sync with the rest of nature. A new study, published Jan. 18 in Current Biology, looks at a beetle with a unique, 48-hour cycle. The large black chafer beetle, Holotrichia parallela, is an agricultural pest in Asia. Every other night, the female beetles emerge from the soil, climb up a host plant ...

National Science Foundation taps NYU Tandon with $5 million grant to advance accessibility

2024-01-18
A team at NYU Tandon School of Engineering will kick off the second phase of an ambitious research project that aims to transform navigation and accessibility for many of the 285 million people with blindness and low vision (pBLV) worldwide. The National Science Foundation (NSF) awarded the project a three-year $5 million grant last month. Led by John-Ross Rizzo – an associate professor in NYU Tandon’s Biomedical Engineering department, associate director of NYU WIRELESS, affiliated faculty at the NYU Tandon Center for Urban Science and Progress (CUSP) and associate professor in the Department of Rehabilitation Medicine at NYU ...

Texas A&M AgriLife Research study may lead to novel obesity treatment 

2024-01-18
      MEDIA INQUIRES   WRITTEN BY Laura Muntean   Paul Schattenberg laura.muntean@ag.tamu.edu   paschattenberg@ag.tamu.edu 601-248-1891   210-859-5752 FOR ...

Semen microbiome health may impact male fertility

2024-01-18
You may have heard about the gut microbiome and its influence on a person’s overall health and well-being. It turns out that the same may hold true for the semen microbiome.   According to researchers from the Department of Urology at UCLA, the semen microbiota might play a crucial role in influencing sperm parameters and enhancing male fertility. Considering recent studies highlighting the microbiome’s significance in overall human health, researchers investigated the semen microbiome to understand its potential impact on male infertility. Exploring the functions of these microorganisms in semen could potentially pave the way for developing treatments targeted ...

South Florida’s nearshore reefs less vulnerable to ocean acidification, study finds

South Florida’s nearshore reefs less vulnerable to ocean acidification, study finds
2024-01-18
South Florida’s Nearshore Reefs Less Vulnerable to Ocean Acidification, Study Finds Results offer a glimmer of hope as climate change impacts coral reefs worldwide Researchers studying South Florida’s coral reefs found that the region’s nearshore reefs and more sheltered inshore areas are less vulnerable to ocean acidification than previously thought – a major climate-related threat to coral reefs as ocean waters absorb more atmospheric CO2 from the burning of fossil fuels. This new study, led by scientists at the University of Miami Rosenstiel School of Marine, Atmospheric, ...

Three University of Houston projects included in $17M+ funding for decarbonization and emissions research

Three University of Houston projects included in $17M+ funding for decarbonization and emissions research
2024-01-18
HOUSTON, January 18, 2024 – The U.S. Department of Energy (DOE) recently announced $17.4 million funding for 19 early-stage research projects focused on expanding clean energy technologies at colleges and universities across America. These projects will establish visiting scholars’ programs, create new academic curricula related to geosciences, and provide interdisciplinary training in humanities-driven science, technology, engineering, and mathematics fields. The list includes three projects from the University of Houston, a Carnegie-designated Tier One Research University. Two of these explore the feasibility and benefit of repurposing ...

Knowing what dogs like to watch could help veterinarians assess their vision

Knowing what dogs like to watch could help veterinarians assess their vision
2024-01-18
Ever wonder what kind of TV shows your dog might choose if they could work the remote control? New research from the University of Wisconsin–Madison’s School of Veterinary Medicine provides some answers, but the study was more interested in solving a longstanding problem in veterinary medicine than turning canine companions into couch potatoes. According to Freya Mowat, veterinary ophthalmologist and professor in the School of Veterinary Medicine’s department of surgical sciences, researchers wanted to determine factors, including age and vision, that influence a dog’s ...

Household income and health insurance among factors in decision to withdraw life support after hemorrhagic stroke

2024-01-18
Living in a high-income neighborhood, having private health insurance, and being older are tied to an increased likelihood that life support will be withdrawn for people who have suffered severe bleeding in the brain, a new study shows. Led by researchers at NYU Grossman School of Medicine, the study focused on the social and economic factors linked to the withdrawal of life support and related death after being hospitalized for intracerebral hemorrhages. Such bleeds, sometimes referred to as hemorrhagic stroke, often lead to swelling in the brain, which can put a patient into a coma and frequently ...

LAST 30 PRESS RELEASES:

Breathable yet protective: Next-gen medical textiles with micro/nano networks

Frequency-engineered MXene supercapacitors enable efficient pulse charging in TENG–SC hybrid systems

Developed an AI-based classification system for facial pigmented lesions

Achieving 20% efficiency in halogen-free organic solar cells via isomeric additive-mediated sequential processing

New book Terraglossia reclaims language, Country and culture

The most effective diabetes drugs don't reach enough patients yet

Breast cancer risk in younger women may be influenced by hormone therapy

Strategies for staying smoke-free after rehab

Commentary questions the potential benefit of levothyroxine treatment of mild hypothyroidism during pregnancy

Study projects over 14 million preventable deaths by 2030 if USAID defunding continues

New study reveals 33% gap in transplant access for UK’s poorest children

Dysregulated epigenetic memory in early embryos offers new clues to the inheritance of polycystic ovary syndrome (PCOS)

IVF and IUI pregnancy rates remain stable across Europe, despite an increasing uptake of single embryo transfer

It takes a village: Chimpanzee babies do better when their moms have social connections

From lab to market: how renewable polymers could transform medicine

Striking increase in obesity observed among youth between 2011 and 2023

No evidence that medications trigger microscopic colitis in older adults

NYUAD researchers find link between brain growth and mental health disorders

Aging-related inflammation is not universal across human populations, new study finds

University of Oregon to create national children’s mental health center with $11 million federal grant

Rare achievement: UTA undergrad publishes research

Fact or fiction? The ADHD info dilemma

Genetic ancestry linked to risk of severe dengue

Genomes reveal the Norwegian lemming as one of the youngest mammal species

Early birds get the burn: Monash study finds early bedtimes associated with more physical activity

Groundbreaking analysis provides day-by-day insight into prehistoric plankton’s capacity for change

Southern Ocean saltier, hotter and losing ice fast as decades-long trend unexpectedly reverses

Human fishing reshaped Caribbean reef food webs, 7000-year old exposed fossilized reefs reveal

Killer whales, kind gestures: Orcas offer food to humans in the wild

Hurricane ecology research reveals critical vulnerabilities of coastal ecosystems

[Press-News.org] New study is one of first to show people with evidence of any remission of diabetes from weight-loss trial had a 40% lower rate of cardiovascular disease and 33% lower rate of chronic kidney disease