(Press-News.org) One dose of the pandemic flu vaccines used in seven European countries conferred good protection against pandemic H1N1 influenza in the 2009-10 season, especially in people aged less than 65 years and in those without any chronic diseases. These findings from a study funded by the European Centre for Disease Prevention and Control (ECDC) and coordinated by EpiConcept, Paris, France, published in this week's PLoS Medicine, give an indication of the vaccine effectiveness for the influenza A (H1N1) 2009 strain included in the 2010-11 seasonal vaccines.
The authors conducted a multi-centre case-control study based on practitioner surveillance networks from seven countries—France, Hungary, Ireland, Italy, Romania, Portugal and Spain. Patients consulting a participating practitioner for influenza-like-illness had a nasal or throat swab taken within eight days of symptom onset. Individuals were considered vaccinated if they had received a dose of the vaccine more than 14 days before the date of onset of influenza like illness and unvaccinated if they were not vaccinated at all or if the vaccine was given less than 15 days before the onset of symptoms.
The authors analysed pandemic influenza vaccination effectiveness in those vaccinated less than 8 days, those vaccinated between, and including, 8 and 14 days and those vaccinated more than 14 days before onset of symptoms compared to those who had never been vaccinated. The authors then used statistical models to measure the effectiveness of pandemic influenza vaccine according to three age groups (< 15, 15-64, and 65+ years of age) and the presence of chronic diseases. These results obtained during the late phase of the pandemic suggest good protection with the pandemic H1N1 vaccine (vaccine effectiveness estimates between 65% and 100%). The findings also suggest that the 2009-10 seasonal influenza vaccine (as opposed to the pandemic H1N1 vaccine) did not protect against pandemic H1N1 influenza illness.
The authors said: "The late availability of the pandemic vaccine and subsequent limited coverage with this vaccine hampered our ability to study vaccine benefits during the outbreak period." They added: "Future studies should include estimation of effectiveness of the new trivalent vaccine in the 2010-2011 season, when vaccination will occur before the influenza season starts."
Bruno C. Ciancio, senior influenza expert from ECDC – who conceived the idea of a European network to measure influenza vaccine effectiveness and collaborated to design the study– stressed: "This study showed the added value of collaboration at European level as concerns vaccine evaluation. In addition, the results obtained are especially important for European countries this season, considering that the predominant influenza strain currently circulating across Europe is influenza A (H1N1).''
INFORMATION:
Funding: This project received funding from the European Centre for Disease Prevention and Control (ECDC, http://www.ecdc.europa.eu) through the call for tender FWC ECDC/07/015. ECDC uses only public money and P. Kramarz and B. C. Cianco (coauthors of the article and working for ECDC) have no conflicts of interest to declare. P. Kramarz and B. C. Ciancio collaborated with EpiConcept in setting up the system, deciding on study design, and writing the article.
Competing Interests: J-M Cohen is a direct advisor for the French Minister of Health (MOH). His salary as Head of re´seau des GROG is financed by the French MOH (76%) and Institut Pasteur (24%). The Institut Pasteur contribution is funded by a pool of five pharmaceutical firms (Roche, Glaxo SmithKline [GSK], Sanofi Pasteur, Solvay, Arge`ne). As Head of Open Rome, he is involved in several epidemiological studies that are partially or fully funded by pharmaceutical companies (Sanofi-Pasteur, GSK, Roche), nonprofit organizations (Mutuelles, Re´saeu DES France) or public institutions (ECDC, CU Strasbourg). He is a member of Association Mieux Prescrire and the advisory boards of Novartis, Roche, and Wyeth (free participation, no compensation). During the past five years, he has received travel grants from Sanofi-Pasteur and Roche. A. Mosnier is a member of the French MOH advisory board on influenza, and adviser for influenza to the French Health Insurance organization. As coordinator of the Re´seau des GROG (French Influenza Sentinel network), her salary is funded by MOH (76%) and Institut Pasteur (24%). Institut Pasteur contribution is funded by a pool of five pharmaceutical firms (GSK, Roche, Sanofi-Pasteur, Solvay, Argene). She is involved, through the other institution with which she is affiliated and salaried (Open Rome research department), in the coordination or analysis of epidemiological studies partially or fully funded by Roche and GSK. She is member of the Groupe d'Expertise et d'Information sur la Grippe (GEIG) Scientific Board. During the last five years, she has received travel grants from Roche for speaking, or participation, at scientific meetings. All other authors have declared that no competing interests exist.
Citation: Valenciano M, Kissling E, Cohen J-M, Oroszi B, Barret A-S, et al. (2011) Estimates of Pandemic Influenza Vaccine Effectiveness in Europe, 2009�: Results of Influenza Monitoring Vaccine Effectiveness in Europe (I-MOVE) Multicentre Case-Control Study. PLoS Med 8(1): e1000388. doi:10.1371/journal.pmed.1000388
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000388
PRESS-ONLY PREVIEW OF THE ARTICLE: www.plos.org/press/plme-08-01-valenciano.pdf
CONTACT:
Marta Valenciano
EpiConcept
+34 638 40 97 07 6
m.valenciano@epiconcept.fr
ECDC Press Office
Tel: +46 (0) 8 586 01 678
Email: press@ecdc.europa.eu
Pandemic H1N1 influenza vaccine effective in 2009-10 flu season
Press release from PLoS Medicine
2011-01-12
ELSE PRESS RELEASES FROM THIS DATE:
Priorities to reduce birth asphyxia focus on implementation
2011-01-12
Joy Lawn from Saving Newborn Lives/Save the Children, South Africa, and an international group of colleagues used a systematic process developed by the Child Health Nutrition Research Initiative (CHNRI) to define and rank research options to reduce mortality from intrapartum-related neonatal deaths (birth asphyxia) by the year 2015. The top one-third of the ranked research investment options was dominated by delivery and implementation research, whilst discovery (basic science) questions were not ranked highly, especially for expected reduction of mortality and inequity ...
Shingles vaccine associated with 55 percent reduced risk of disease
2011-01-12
PASADENA, Calif. (January 11, 2011) – Receiving the herpes zoster vaccine was associated with a 55 percent reduced risk of developing shingles, according to a Kaiser Permanente study of 300,000 people that appears in the current issue of the Journal of the American Medical Association.
This retrospective study observed the outcomes of the effectiveness of the herpes zoster vaccine in a large, diverse population of men and women ages 60 years and older. Researchers found a significant reduced risk of shingles across all sub-groups -- those who are healthy as well as those ...
Behavioral therapy program reduces incontinence following radical prostatectomy
2011-01-12
For men with incontinence for at least one year following radical prostatectomy, participation in a behavioral training program that included pelvic floor muscle training, bladder control strategies and fluid management, resulted in a significant reduction in the number of incontinence episodes, according to a study in the January 12 issue of JAMA. The researchers also found that the addition of biofeedback and pelvic floor electrical stimulation provided no additional benefit.
"Men in the United States have a 1 in 6 lifetime prevalence of prostate cancer. Although survival ...
Zoster vaccine associated with lower risk of shingles in older adults
2011-01-12
Vaccination for herpes zoster, a painful rash commonly known as shingles, among a large group of older adults was associated with a reduced risk of this condition, regardless of age, race or the presence of chronic diseases, according to a study in the January 12 issue of JAMA.
"The pain of herpes zoster is often disabling and can last for months or even years, a complication termed postherpetic neuralgia. Approximately 1 million episodes of herpes zoster occur in the United States annually, but aside from age and immunosuppression, risk factors for this condition are ...
Comparison of medications for heart failure finds difference in risk of death
2011-01-12
In a comparison of the angiotensin II receptor blockers (ARBs) candesartan and losartan, used by patients with heart failure, candesartan was associated with a lower risk of death at 1 and 5 years, according to a study in the January 12 issue of JAMA.
Angiotensin II receptor blockers reduce cardiovascular mortality and heart failure (HF) hospitalization in patients with HF with reduced left ventricular ejection fraction (LVEF; a measure of how well the left ventricle of the heart pumps with each contraction). Despite variable effects of different ARBs, they have not ...
For CABG, use of artery from arm does not appear to be superior to vein grafts from the leg
2011-01-12
Use of a radial artery (located within the forearm, wrist and hand) graft compared with a saphenous vein (from the leg) graft for coronary artery bypass grafting did not result in improved angiographic patency (the graft being open, unobstructed) one year after the procedure, according to a study in the January 12 issue of JAMA.
Coronary artery bypass grafting (CABG) is one of the most common operations performed, with a database indicating that in the United States, 163,048 patients had CABG surgery in 2008. The success of CABG depends on the long-term patency of the ...
Study finds more breaks from sitting are good for waistlines and hearts
2011-01-12
It is becoming well accepted that, as well as too little exercise, too much sitting is bad for people's health. Now a new study has found that it is not just the length of time people spend sitting down that can make a difference, but also the number of breaks that they take while sitting at their desk or on their sofa. Plenty of breaks, even if they are as little as one minute, seem to be good for people's hearts and their waistlines.
The study, which is published online today (Wednesday 12 January) in the European Heart Journal [1], is the first in a large, representative, ...
Acne bug could be the cause of your infections
2011-01-12
Previously, researchers thought the detection of P. acnes at the site of these infections was due to contamination from the skin. For example, an infection at a site within the body after surgery, could have been caused by bacteria transferred to an open wound from the skin during an operation. But recent research has contradicted this, suggesting P. acnes already within the body, may be the cause. Although it is often disregarded as a harmless bystander when found in blood and tissue swabs taken from patients, we should not rule out this bug in the diagnosis of disease.
People ...
New method for reporting solar data
2011-01-12
Washington, D.C. (January 11, 2011) -- A straightforward new way to calculate, compile, and graphically present solar radiation measurements in a format that is accessible to decision makers and the general public has been developed by researchers at the University of Texas at Austin.
The method presents solar data in a framework that "can be used by policymakers, businesses, and the public to understand the magnitude of solar resources in a given region, which might aid consumers in selecting solar technologies, or policymakers in designing solar policies," says David ...
Trapped sunlight cleans water
2011-01-12
Washington, D.C. (January 11, 2011) -- High energy costs are one drawback of making clean water from waste effluents. According to an article in the journal Biomicrofluidics, which is published by the American Institute of Physics, a new system that combines two different technologies proposes to break down contaminants using the cheapest possible energy source, sunlight. Microfluidics – transporting water through tiny channels -- and photocatalysis -- using light to break down impurities – come together in the science of optofluidics.
"These two technologies have been ...
LAST 30 PRESS RELEASES:
Scientists unlock secrets behind flowering of the king of fruits
Texas A&M researchers illuminate the mysteries of icy ocean worlds
Prosthetic material could help reduce infections from intravenous catheters
Can the heart heal itself? New study says it can
Microscopic discovery in cancer cells could have a big impact
Rice researchers take ‘significant leap forward’ with quantum simulation of molecular electron transfer
Breakthrough new material brings affordable, sustainable future within grasp
How everyday activities inside your home can generate energy
Inequality weakens local governance and public satisfaction, study finds
Uncovering key molecular factors behind malaria’s deadliest strain
UC Davis researchers help decode the cause of aggressive breast cancer in women of color
Researchers discovered replication hubs for human norovirus
SNU researchers develop the world’s most sensitive flexible strain sensor
Tiny, wireless antennas use light to monitor cellular communication
Neutrality has played a pivotal, but under-examined, role in international relations, new research shows
Study reveals right whales live 130 years — or more
Researchers reveal how human eyelashes promote water drainage
Pollinators most vulnerable to rising global temperatures are flies, study shows
DFG to fund eight new research units
Modern AI systems have achieved Turing's vision, but not exactly how he hoped
Quantum walk computing unlocks new potential in quantum science and technology
Construction materials and household items are a part of a long-term carbon sink called the “technosphere”
First demonstration of quantum teleportation over busy Internet cables
Disparities and gaps in breast cancer screening for women ages 40 to 49
US tobacco 21 policies and potential mortality reductions by state
AI-driven approach reveals hidden hazards of chemical mixtures in rivers
Older age linked to increased complications after breast reconstruction
ESA and NASA satellites deliver first joint picture of Greenland Ice Sheet melting
Early detection model for pancreatic necrosis improves patient outcomes
Poor vascular health accelerates brain ageing
[Press-News.org] Pandemic H1N1 influenza vaccine effective in 2009-10 flu seasonPress release from PLoS Medicine