Prostate cancer screening with PSA, Kallikrein Panel, and MRI

JAMA

2024-04-06

(Press-News.org) About The Study: In this preliminary descriptive report from an ongoing randomized clinical trial, one additional high-grade cancer per 196 men and one low-grade cancer per 909 men were detected among those randomized to be invited to undergo a single prostate cancer screening intervention compared with those not invited to undergo screening. These preliminary findings from a single round of screening should be interpreted cautiously, pending results of the study’s primary mortality outcome.

Authors: Anssi Auvinen, M.D., Ph.D., of Tampere University in Tampere, Finland, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.3841)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being released to coincide with presentation at the 39th Annual European Association of Urology Congress.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.3841?guestAccessKey=0ec76eb2-a05b-4ae3-b31c-7a662e979189&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040624

END

ELSE PRESS RELEASES FROM THIS DATE:

PSA screening and 15-year prostate cancer mortality

2024-04-06

About The Study: A single invitation for prostate-specific antigen (PSA) screening compared with standard practice without routine screening reduced prostate cancer deaths at a median follow-up of 15 years in this secondary analysis of a randomized clinical trial. However, the absolute reduction in deaths was small. Authors: Richard M. Martin, B.M., B.S., Ph.D., of the University of Bristol in Bristol, United Kingdom, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.4011) Editor’s ...

Screening with a PSA test has a small impact on prostate cancer deaths but leads to overdiagnosis

2024-04-06

The largest study to date investigating a single invitation to a PSA blood test* to screen for prostate cancer has found it had a small impact on reducing deaths, but also led to overdiagnosis and missed early detection of some aggressive cancers. The CAP trial, published in the Journal of the American Medical Association (JAMA) and carried out by researchers from the universities of Bristol, Oxford and Cambridge, involved over 400,000 men aged 50-69. Just under half received a single invitation for a PSA test as part of the trial. After following up for 15 years, there was a small difference in the number of men who died from prostate cancer between the ...

Five-year interval is safe for prostate cancer screening, research shows

2024-04-06

A simple blood test every five years is sufficient to screen low risk men for prostate cancer, new research has shown. The PSA blood test checks the level of prostate-specific antigen, a marker for prostate cancer. In Europe, only Lithuania routinely screens men for prostate cancer based on their PSA levels, as the test has historically been seen as insufficiently reliable. The German study, presented at the European Association of Urology (EAU) Congress in Paris today [April 6, 2024], involved over 12,500 men aged between 45-50 taking part in the ongoing ...

Urine test halves painful procedures in bladder cancer follow up, new trial shows

2024-04-06

A simple urine test can more than halve the number of cystoscopies necessary to follow up high-risk bladder cancer patients, new research has found. Cystoscopies involve inserting a flexible probe through the urethra into the bladder, which allows a clinician to look at the bladder lining for signs of cancer. While they are predominantly safe procedures, cystoscopies do incur some risk of urinary infections and bleeding. They can also cause pain and discomfort. Initial results from a two-year study, presented today ...

Study: Epilepsy patients benefit from structured 'seizure action plans'

2024-04-06

COLUMBUS, Ohio – A new 16-week study of 204 adult epilepsy patients found that 98% of participants believe that all patients with epilepsy should have a seizure action plan (SAP), regardless of seizure status. These plans can help patients with epilepsy to safely manage seizure emergencies. But healthcare providers don’t always discuss them with their patients. Researchers at The Ohio State University Wexner Medical Center and College of Medicine found that standardizing a structured SAP can help adults with epilepsy safely manage seizures. Study findings published online today in the journal Neurology: Clinical Practice. “Our work suggests that simple discussions between ...

Innovative sensing platform unlocks ultrahigh sensitivity in conventional sensors

2024-04-05

By Shawn Ballard Optical sensors serve as the backbone of numerous scientific and technological endeavors, from detecting gravitational waves to imaging biological tissues for medical diagnostics. These sensors use light to detect changes in properties of the environment they’re monitoring, including chemical biomarkers and physical properties like temperature. A persistent challenge in optical sensing has been enhancing sensitivity to detect faint signals amid noise. New research from Lan Yang, the Edwin H. & Florence G. Skinner Professor in the Preston M. Green Department of Electrical & Systems Engineering in the McKelvey School ...

Dinosaur study challenges Bergmann’s rule

2024-04-05

When you throw dinosaurs into the mix, sometimes you find that a rule simply isn’t. A new study led by scientists at the University of Alaska Fairbanks and the University of Reading calls into question Bergmann’s rule, an 1800s-era scientific principle stating that animals in high-latitude, cooler climates tend to be larger than close relatives living in warmer climates. The fossil record shows otherwise. “Our study shows that the evolution of diverse body sizes in dinosaurs and mammals cannot be reduced to simply being a function of latitude or temperature,” said Lauren Wilson, a UAF graduate student and a lead author ...

NRL charters Navy’s quantum inertial navigation path to reduce drift

2024-04-05

WASHINGTON – U.S. Naval Research Laboratory (NRL) researchers have developed a patent-pending Continuous 3D-Cooled Atom Beam Interferometer derived from a patented cold and continuous beam of atoms to explore atom-interferometry-based inertial measurement systems as a path to reduce drift in Naval navigation systems. Inertial navigation is a self-contained navigation technique in which measurements provided by accelerometers and gyroscopes are used to track the position and orientation of an object relative to a known starting point, orientation and velocity. Quantum inertial navigation is a new field of research and ...

Portsmouth researchers enable detection of remarkable gravitational-wave signal

2024-04-05

Researchers from the University of Portsmouth’s Institute of Cosmology and Gravitation (ICG) have helped to detect a remarkable gravitational-wave signal, which could hold the key to solving a cosmic mystery. The discovery is from the latest set of results announced today (5 April) by the LIGO-Virgo-KAGRA collaboration, which comprises more than 1,600 scientists from around the world, including members of the ICG, that seeks to detect gravitational waves and use them for exploration of fundamentals of science. In May 2023, shortly after ...

Common loons threatened by declining water clarity

2024-04-05

The Common Loon, an icon of the northern wilderness, is under threat from climate change due to reduced water clarity, according to a new study authored by Chapman University professor, Walter Piper. The study, published April 1 in Ecology, followed up an earlier paper that showed substantial reproductive decline in the author’s study area in northern Wisconsin. The paper is the first clear evidence demonstrating an effect of climate change on this charismatic species. Specifically, the paper shows that July rainfall results in reduced July water clarity in loon territories. Reduced water clarity, in turn, ...

Prostate cancer screening with PSA, Kallikrein Panel, and MRI

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: