Ivonescimab plus chemotherapy in non–small cell lung cancer with EGFR variant

JAMA

2024-05-31

(Press-News.org) About The Study: Ivonescimab plus chemotherapy significantly improved progression-free survival with tolerable safety profile in patients with non–small cell lung cancer who previously underwent EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment and may offer a new treatment option for patients with TKI resistance.

Quote from corresponding author Li Zhang, M.D.:

“For patients with non-small cell lung cancer whose illness has progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, especially the third generation TKIs, optimal treatment options remain limited.

“This randomized, placebo-controlled phase 3 study demonstrated ivonescimab plus chemotherapy significantly improved progression-free survival (7.1 vs 4.8 months) compared with chemotherapy alone in TKI-treated non-small cell lung cancer.

“Based on the results of this study, ivonescimab has been approved in China as a new treatment option for those patients. An international multi-center study of this treatment regimen is ongoing.”

Contact information for Li Zhang, M.D.: email zhangli@sysucc.org.cn.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.10613)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.10613?guestAccessKey=4a907c26-6d2e-46e7-94b1-d0b5670ff18a&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=053124

END

ELSE PRESS RELEASES FROM THIS DATE:

Mussels downstream of wastewater treatment plant contain radium, study reports

2024-05-31

UNIVERSITY PARK, Pa. — Burrowed into streambeds and rarely moving for their decades-long lifespans, freshwater mussels are biomonitors, meaning they indicate how clean their environment is, according to Penn State researchers. As the bivalves feed on organic matter and filter the water around them, their inner tissues and hard shells begin to reflect whatever is in their environment — including radioactive particles. A pair of researchers from Penn State’s Department of Civil and Environment ...

This self-powered sensor could make MRIs more efficient

2024-05-31

MRI scans are commonly used to diagnose a variety of conditions, anything from liver disease to brain tumors. But, as anyone who has been through one knows, patients must remain completely still to avoid blurring the images and requiring a new scan. A prototype device described in ACS Sensors could change that. The self-powered sensor detects movement and shuts down an MRI scan in real time, improving the process for patients and technicians. During an MRI scan, a patient must stay entirely still for several minutes at a time, otherwise “motion artifacts” could appear and blur the final image. To ensure a clear picture, patient movement needs to be identified as ...

Cognitive declines preceding Alzheimer’s diagnosis lead to credit card, mortgage delinquency

2024-05-31

(May 31, 2024) — In the years prior to an Alzheimer’s disease or other memory disorder diagnosis, credit scores begin to weaken and payment delinquency begins to increase, concludes new research led by Georgetown University. The findings show consistent deterioration in these financial outcomes over the quarters leading up to diagnosis. The findings also show that credit card and mortgage delinquencies, specifically, both increase substantially prior to diagnosis. The research was released today by the Federal Reserve Bank of New York (FRBNY). (“The Financial Consequences of Undiagnosed Memory Disorders”). “Most memory disorders ...

Eye-tracking techniques could help primary care providers diagnose autism sooner, more accurately

2024-05-31

INDIANAPOLIS — Nearly 3% of all children in the United States are diagnosed with autism, according to the Centers for Disease Control and Prevention. But a collaborative team of researchers at Indiana University and Purdue University are finding ways to make the right diagnosis sooner. “The number of children needing autism evaluations exceeds the capacity of specialists trained to provide this service,” said Rebecca McNally Keehn, PhD, assistant professor of pediatrics at the IU School of Medicine. “Children and their families are currently waiting a year or more to access evaluations. ...

Antibodies may aid effort to fight influenza B: Study

2024-05-31

Researchers at Vanderbilt University Medical Center have isolated human monoclonal antibodies against influenza B, a significant public health threat that disproportionately affects children, the elderly and other immunocompromised individuals. Seasonal flu vaccines cover influenza B and the more common influenza A but do not stimulate the broadest possible range of immune responses against both viruses. In addition, people whose immune systems have been weakened by age or illness may not respond effectively to the flu shot. Small-molecule drugs that block neuraminidase, a major surface glycoprotein of the ...

ASCO: Novel CAR T therapy and shorter targeted therapy durations show promise for patients with leukemia

2024-05-31

Novel CAR T cell therapy obe-cel yields strong remission rates in adults with relapsed or refractory B-ALL (Abstract 6504) The novel anti-CD19 autologous chimeric antigen receptor (CAR) T cell therapy obecabtagene autoleucel (obe-cel) achieved durable remissions in 40% of patients with relapsed or refractory B-ALL without a subsequent stem cell transplant (SCT), according to results from the Phase Ib/II FELIX clinical trial presented today by Elias Jabbour, M.D., professor of Leukemia. At a median follow-up of 21.5 months, these patients were in ongoing remission ...

Synthetic plugs offer alternative to total knee replacements

2024-05-31

Osteochondral defects (OCDs) can cause damage to cartilage and underlying bone, leading to chronic pain and loss of joint function. Depending on the extent of damage, individuals must undergo surgical treatment, the most extensive being total knee replacement, which over 800,000 Americans undergo each year. Dr. Melissa Grunlan, professor in the Department of Biomedical Engineering at Texas A&M University, received a grant from the National Institute of Arthritis and Musculoskeletal and Skin Disease, a suborganization of the National Institutes ...

CU researchers analyze prevalence, impact of ethical or religious barriers to providing medical aid in dying

2024-05-31

Recently published research led by the University of Colorado Anschutz Medical Campus examined the prevalence — and impact — of physicians’ ethical or religious barriers to their involvement in medical aid in dying (MAiD), a multi-step process where a physician provides a terminally ill adult with decision-making capacity with a lethal dose of medication to end their life. The research article, “Conscience-Based Barriers to Medical Aid in Dying: A Survey of Colorado Physicians,” was published this May in the Journal of General Internal Medicine. It shows that 26% of physician ...

Want to be a successful scientist? The McClements family has some tips

2024-05-31

The latest book of prolific author David Julian McClements is a family affair. The Distinguished Professor of Food Science, along with his daughter Isobelle Farrell McClements and nephew Jake McClements, have written “How to be a Successful Scientist: A Guide for Graduate Students, Postdocs, and Professors” (Springer, 2024). The three authors offer different perspectives as scientists at different stages in their careers. Julian McClements, who has published more than 1,300 scientific articles and numerous books, is the most highly ...

Overcoming barriers to heat pump adoption in cold climates and avoiding the 'energy poverty trap'

2024-05-31

Converting home heating systems from natural gas furnaces to electric heat pumps is seen as a way to address climate change by reducing greenhouse gas emissions. But a new University of Michigan study of 51 Southeast Michigan households shows that switching to efficient, cold-climate heat pumps would increase annual utility bills by an average of about $1,100. Home weatherization upgrades, such as adding attic insulation and sealing around doors and windows, could help reduce utility bills and make ...

LAST 30 PRESS RELEASES:

Scientists trace microplastics in fertilizer from fields to the beach

The Lancet Obstetrics, Gynecology, & Women’s Health: Taking paracetamol during pregnancy does not increase risk of autism, ADHD or intellectual disabilities, confirms new gold-standard evidence review