Ohio State develops searchable database for Alzheimer’s research
Comprehensive, user-friendly repository offers broader spectrum of Alzheimer’s datasets
2024-06-06
(Press-News.org) COLUMBUS, Ohio – A searchable database is now ready to help study Alzheimer’s disease.
Neuroscience and biomedical informatics researchers at The Ohio State University Wexner Medical Center and College of Medicine created the comprehensive, user-friendly repository.
The free database – known as ssREAD – is outlined in a manuscript published online in Nature Communications.
Alzheimer’s disease is the most common cause of dementia, accounting for up to 80% of cases. An estimated 6.7 million Americans who are age 65 and older are living with Alzheimer's dementia today, according to the Alzheimer’s Association’s 2023 Alzheimer's disease facts and figures report.
This database will help study the pathology of Alzheimer’s disease. Pathology examines the cause, development, structural/functional changes and natural history associated with diseases.
Molecular signatures underlying Alzheimer's disease pathology have been increasingly explored through single-cell and single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and spatial transcriptomics.
“These technologies have cast fresh light on the exploration of Alzheimer’s disease pathogenesis and sex difference at the cellular and molecular levels. Our ssREAD repository offers a broader spectrum of Alzheimer’s disease-related datasets, with an optimized analytical pipeline and improved usability,” said study co-corresponding author Hongjun “Harry” Fu, PhD, assistant professor of neuroscience at Ohio State.
Datasets
The database encompasses 277 integrated datasets from 67 Alzheimer’s disease-related scRNA-seq & snRNA-seq studies, totaling 7,332,202 cells. The repository also includes 381 spatial transcriptomics samples from 85 human and mouse studies.
Detailed annotations including cell types and spatial layers
Differential gene expressions and functional enrichment analysis
Spatially variable genes and deconvolution with single-cell datasets
Interactive visualizations
User-friendly web server to provide comprehensive analysis interpretations and filters support multiple selections
Scatter plots for clusters, cell types, and spatial layers
Feature plots and violin plots for gene expression profile
Real-time gene set enrichment analysis
“We are closing the gap for researchers by creating this specialized database. Integrating these diverse datasets and conditions will be invaluable for researchers studying the complex landscape of Alzheimer’s disease,” said Qin Ma, PhD, professor in Ohio State’s department of biomedical informatics.
###
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2024-06-06
Economic analysis of the E-MOTIVE trial finds that average cost per patient of drape and treatment to save women’s lives incurs minimal additional cost compared with usual care, while significantly improving health outcomes.
The additional cost to achieve the improved outcome could be as little as 30 US cents extra- on average, compared to usual care.
Post-partum haemorrhage currently affects 14m women around the world and leads to 70,000 deaths a year which is equivalent to one woman dying every 6 minutes
A lifesaving package including early detection and bundled treatment for ...
2024-06-06
The hidden challenges faced by people with tooth loss and dentures has been identified by new research from the University of Sheffield.
Improvements in dental care, more people living longer and the social value placed on having a healthy smile has led to people keeping their own teeth longer, but it has also led to an increasing number of people needing some kind of restoration work including crowns, bridges and implants.
Many of these treatments remain unobtainable for most people due to the availability of NHS dentists and the high cost of private dental work. Removable dentures are often the only viable option for anyone experiencing tooth loss with an estimated ...
2024-06-06
Nano-agriculture: Sustainable solutions for global food security
PITTSBURGH—Researchers in the Department of Civil and Environmental Engineering at Carnegie Mellon University are using findings from nanomedicine and digital twin technologies to understand the new field of Plant Nanobiotechnology, address unsustainable agricultural practices, and meet increasing global food demands.
Currently, agriculture accounts for 14-28% of global greenhouse gas emissions and 70% of all freshwater withdraws. This, in addition to a range of other factors from extreme weather ...
2024-06-06
WORLD-FIRST STUDY INTO PRECISION MEDICINE FOR HIGH-RISK CHILDHOOD CANCER YIELDS EXTRAORDINARY RESULTS
VIDEO - https://www.youtube.com/watch?v=bwyugwVwNzc
In a world-first, Australian researchers and clinicians have shown that precision medicine – where treatment is tailored to an individual child’s cancer – leads to significantly improved outcomes in children with high risk cancer.
In a study published this week in the leading international journal Nature Medicine, the researchers found that precision medicine (also called personalised medicine) was shown to be superior to standard or non-guided therapy, both in terms of clinical response and survival.
A staggering ...
2024-06-06
Advanced technologies enable the controlled release of medicine to specific cells in the body. Scientists argue these same technologies must be applied to agriculture if growers are to meet increasing global food demands.
In a new Nature Nanotechnology journal review paper, scientists from UC Riverside and Carnegie Mellon University highlight some of the best-known strategies for improving agriculture with nanotechnology.
Nanotechnology is an umbrella term for the study and design of microscopically small things. How small? A nanometer is one billionth of a meter, or about 100,000 times smaller ...
2024-06-06
Peer Reviewed | Observational study | People
Researchers at Queen Mary University of London have developed a new method for predicting dementia with over 80% accuracy and up to nine years before a diagnosis. The new method provides a more accurate way to predict dementia than memory tests or measurements of brain shrinkage, two commonly used methods for diagnosing dementia.
The team, led by Professor Charles Marshall, developed the predictive test by analysing functional MRI (fMRI) scans to detect changes in the brain’s ‘default mode network’ (DMN). The DMN connects regions of the brain ...
2024-06-06
With the European Parliament elections now underway, millions of EU citizens are finalizing their decisions about which political party best represents their views.
But anyone using LlamaChat, one of the major new AI chatbots, is very likely to be confronted with biased answers. It turns out that the large language model developed by Meta, upon which LlamaChat is based, has clear political leanings. This has been demonstrated in a new study from the University of Copenhagen in which Department of Computer Science researchers examined the language model's knowledge of political groups in the European Parliament. Moreover, they tested LlamaChat’s ...
2024-06-06
Philadelphia, June 6, 2024 – A new study in Heart Rhythm, the official journal of the Heart Rhythm Society, the Cardiac Electrophysiology Society, and the Pediatric & Congenital Electrophysiology Society, published by Elsevier, examined the potential dangers of consuming energy drinks for patients with genetic heart diseases. A cohort of 144 sudden cardiac arrest survivors was examined at Mayo Clinic, of which seven patients (5%) had consumed one or more energy drinks in close proximity to their cardiac ...
2024-06-06
A review of research to-date reveals the complex nature of revealing a diagnosis of a sexually transmitted infection (STI) to a partner ahead of engaging in sexual activity.
With individuals experiencing a variety of feelings and emotions related to the prospect of disclosure, the research shows that only around half or fewer individuals felt able to disclose their diagnosis to a partner before sexual engagement.
Peer-reviewed results, published today in The Journal of Sex Research, also show a similar number of people believed they should have to disclose having a STI to a partner prior to engaging in sexual intercourse.
In order ...
2024-06-06
Australia’s ski industry is at risk of major disruptions and shorter seasons if the current level of climate pollution continues, according to new modelling from Protect Our Winters Australia (POW) and The Australian National University (ANU).
The report found the average ski season across all resorts in Australia will be 44 days shorter by 2050 under a mid-greenhouse gas emissions scenario and 55 days shorter under a high-emissions scenario.
It also shows that despite a dramatic decline in snowfall under mid- and high-emissions scenarios, the ...
LAST 30 PRESS RELEASES:
[Press-News.org] Ohio State develops searchable database for Alzheimer’s research
Comprehensive, user-friendly repository offers broader spectrum of Alzheimer’s datasets
