PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Entering the golden age for antibody-drug conjugates in gynecologic cancer

Entering the golden age for antibody-drug conjugates in gynecologic cancer
2024-07-12
(Press-News.org)

“We are optimistic that the incorporation of ADCs into the treatment of aggressive tumors and treatment refractory gynecologic cancers will improve quality of life and survival outcomes in our patients.”

BUFFALO, NY- July 12, 2024 – A new editorial paper was published in Oncoscience (Volume 11) on May 20, 2024, entitled, “Entering the golden age for antibody-drug conjugates in gynecologic cancer.”

In this new editorial, researchers Michelle Greenman, Blair McNamara, Levent Mutlu, and Alessandro D. Santin from Yale University School of Medicine discuss gynecologic cancers. Biologically aggressive tumors such as uterine serous carcinoma (USC) and carcinosarcoma (CS) are aggressive subtypes of endometrial cancer with a poor prognosis and a disproportionately high mortality rate. 

“Cytoreductive surgery along with chemotherapy is critical in treatment.”

However, recurrence is common, requiring multiple lines and combinations of chemotherapy. Use of immunotherapy in combination with gold standard chemotherapy regimens and targeted drugs represent novel modalities in treatment endowed with a remarkable potential in endometrial cancer patients. In a recent publication, entitled “In Vivo and In Vitro Efficacy of Trastuzumab Deruxtecan in Uterine Serous Carcinoma” the researchers evaluated trastuzumab-deruxtecan (T-DXd), a HER2-directed antibody drug conjugate (ADC) against biologically aggressive uterine tumors.

“We demonstrated for the first time the remarkable preclinical activity of T-DXd against primary USC cells lines as well as USC xenografts overexpressing HER2/neu.”

 

Continue reading: DOI: https://doi.org/10.18632/oncoscience.604 

Correspondence to: Alessandro D. Santin

Email: alessandro.santin@yale.edu 

Keywords: antibody-drug conjugates, gynecologic malignancies, precision medicine
 

About Oncoscience: 

Oncoscience is a peer-reviewed, open-access, traditional journal covering the rapidly growing field of cancer research, especially emergent topics not currently covered by other journals. This journal has a special mission: Freeing oncology from publication cost. It is free for the readers and the authors.

Oncoscience is indexed and archived by PubMed, PubMed Central, Scopus, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncoscience, visit Oncoscience.us and connect with us on social media:

X, formerly Twitter  Instagram Facebook  YouTube  LinkedIn   

For media inquiries, please contact media@impactjournals.com.

 

Oncoscience Journal Office

6666 East Quaker Str., Suite 1

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 4

###

END


[Attachments] See images for this press release:
Entering the golden age for antibody-drug conjugates in gynecologic cancer

ELSE PRESS RELEASES FROM THIS DATE:

Judge: Texas university must release records on research study that resulted in deaths of dozens of animals

2024-07-12
SAN ANGELO, Texas —Tom Green County District Court Judge Barbara L. Walther ruled Thursday, July 11, 2024, that Angelo State University must release public records relating to an experiment conducted on dozens of mice that resulted in the animals’ unnecessary suffering and death, reportedly to study the impact of the foster care system on human children. The ruling overturns Texas Attorney General Ken Paxton’s Nov. 17, 2022 decision to side with the university in denying the records. On July 13, 2023, the Physicians Committee for Responsible Medicine, a Washington, D.C. based health advocacy group of more than 17,000 doctor members that encourages higher standards ...

UMass Amherst food scientist rises to the challenge of giving marbled fatty feel and taste to plant-based meat

UMass Amherst food scientist rises to the challenge of giving marbled fatty feel and taste to plant-based meat
2024-07-12
One of the challenges of creating realistic-looking and delectable plant-based meat is mimicking the marbled effect of animal fat that many carnivores expect and enjoy. A University of Massachusetts Amherst food scientist has a plan to tackle this quandary by developing new technology supported by a $250,000 grant from the Good Food Institute. The not-for-profit think tank promotes plant-based alternatives to meat, dairy and eggs, as well as cultivated “clean meat” grown from animal cells in a facility. The technology proposed ...

Complex impact of large wildfires on ozone layer dynamics unveiled by new study

2024-07-12
In a revelation that highlights the fragile balance of our planet's atmosphere, scientists from China, Germany, and the USA have uncovered an unexpected link between massive wildfire events and the chemistry of the ozone layer. Published in Science Advances, this study reveals how wildfires, such as the catastrophic 2019/20 Australian bushfires, impact the stratosphere in previously unseen ways. The ozone layer, a crucial shield protecting life on Earth from harmful ultraviolet (UV) radiation, has been on a path to ...

Brain inflammation triggers muscle weakness after infections

Brain inflammation triggers muscle weakness after infections
2024-07-12
Infections and neurodegenerative diseases cause inflammation in the brain. But for unknown reasons, patients with brain inflammation often develop muscle problems that seem to be independent of the central nervous system. Now, researchers at Washington University School of Medicine in St. Louis have revealed how brain inflammation releases a specific protein that travels from the brain to the muscles and causes a loss of muscle function. The study, in fruit flies and mice, also identified ways to block this process, which could have ...

Research alert: All stem cell therapies are not created equal

2024-07-12
Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current “one-cell-cures-all” paradigm in orthopedic stem cell therapeutics and highlight the need for more informed and rigorous characterization of injectable stem cell therapies before they are marketed for use in patients. The researchers analyzed cell populations of autologous bone marrow aspirate concentrate (BMAC) and adipose-derived ...

Complex impact of large wildfires on ozone layer dynamics

2024-07-12
The ozone layer, a crucial shield protecting life on Earth from harmful ultraviolet (UV) radiation, has been on a path to recovery thanks to the Montreal Protocol. This landmark international treaty, adopted in 1987, successfully led to phasing out the production of numerous substances responsible for ozone depletion. Over the past decades, the ozone layer has shown significant signs of healing, a testament to global cooperation and environmental policy. However, the stability of this vital atmospheric layer is now facing a new and unexpected challenge. During the 2019/20 Australian wildfires, ...

AI found to boost individual creativity – at the expense of less varied content

2024-07-12
Stories written with AI assistance have been deemed to be more creative, better written and more enjoyable. A new study published in the journal Science Advances finds that AI enhances creativity by boosting the novelty of story ideas as well as the ‘usefulness’ of stories – their ability to engage the target audience and potential for publication. It finds that AI “professionalizes” stories, making them more enjoyable, more likely to have plot twists, better written and less boring. In ...

Texas A&M research collaboration uncovers how domestic rabbits become feral in the wild

2024-07-12
Researchers at the Texas A&M School of Veterinary Medicine and Biomedical Sciences (VMBS) have uncovered how natural selection “rewilds” domestic rabbits. The study, published in Nature Ecology and Evolution, helps answer the question of how normally tame rabbits — which have many natural predators — can become a force of ecological destruction when purposefully or accidentally reintroduced to the wild. Here Comes Peter Cottontail Every gardener knows how much of a nuisance rabbits can be, but ...

Scientists find new way global air churn makes particles

2024-07-12
By Leah Shaffer You can think of our atmosphere as a big chemistry set, a global churn of gaseous molecules and particles that constantly bounce off and change each other in complicated ways. While the particles are very small, often less than 1% of the thickness of human hair, they have outsized impacts. For example, particles are the seeds of cloud droplets, and the abundance of the particles changes the reflectivity and the amount of clouds, rainfall and climate. Now, researchers at Washington University in St. ...

Researchers discover a new neural biomarker for OCD

2024-07-12
A recent study from Baylor College of Medicine and Texas Children’s Hospital has identified a specific neural activity pattern as a novel biomarker to accurately predict and monitor the clinical status of individuals with obsessive-compulsive disorder (OCD) who have undergone deep brain stimulation (DBS),  a rapidly emerging therapeutic approach for severe psychiatric disorders. The study, led by led by Drs. Sameer Sheth and Wayne Goodman along with co-lead authors, Drs. Nicole Provenza, ...

LAST 30 PRESS RELEASES:

Premenstrual symptoms linked to increased risk of cardiovascular disease

Newly discovered remains of ancient river landscapes control ice flow in East Antarctica

Newly discovered interstellar object 'may be oldest comet ever seen'

Animal-inspired AI robot learns to navigate unfamiliar terrain

Underserved youth less likely to visit emergency department for concussion in Ontario, study finds

‘Molecular shield’ placed in the nose may soon treat common hay fever trigger

Beetles under climate stress lay larger male eggs: Wolbachia infection drives adaptive reproduction strategy in response to rising temperature and CO₂

Groundbreaking quantum study puts wave-particle duality to work

Weekly injection could be life changing for Parkinson’s patients

Toxic metals linked to impaired growth in infants in Guatemala

Being consistently physically active in adulthood linked to 30–40% lower risk of death

Nerve pain drug gabapentin linked to increased dementia, cognitive impairment risks

Children’s social care involvement common to nearly third of UK mums who died during perinatal period

‘Support, not judgement’: Study explores links between children’s social care involvement and maternal deaths

Ethnic minority and poorer children more likely to die in intensive care

Major progress in fertility preservation after treatment for cancer of the lymphatic system

Fewer complications after additional ultrasound in pregnant women who feel less fetal movement

Environmental impact of common pesticides seriously underestimated

The Milky Way could be teeming with more satellite galaxies than previously thought

New study reveals surprising reproductive secrets of a cricket-hunting parasitoid fly

Media Tip Sheet: Symposia at ESA2025

NSF CAREER Award will power UVA engineer’s research to improve drug purification

Tiny parasitoid flies show how early-life competition shapes adult success

New coating for glass promises energy-saving windows

Green spaces boost children’s cognitive skills and strengthen family well-being

Ancient trees dying faster than expected in Eastern Oregon

Study findings help hone precision of proven CVD risk tool

Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later

Introducing BioEmu: A generative AI Model that enables high-speed and accurate prediction of protein structural ensembles

Replacing mutated microglia with healthy microglia halts progression of genetic neurological disease in mice and humans

[Press-News.org] Entering the golden age for antibody-drug conjugates in gynecologic cancer