(Press-News.org) About The Study: In an open-label trial in patients with heart failure with preserved ejection fraction with left ventricular ejection fraction of 60% or greater, mavacamten, a cardiac myosin inhibitor, was associated with improvements in biomarkers of cardiac wall stress and injury, with no sustained reductions in left ventricular ejection fraction observed.
Corresponding Authors: To contact the corresponding authors, email Sanjiv J. Shah, MD, (sanjiv.shah@northwestern.edu) and Scott D. Solomon, MD, (ssolomon@bwh.harvard.edu).
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamacardio.2024.3810)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
# # #
Media advisory: This study is being presented at the Heart Failure Society of America Annual Scientific Meeting.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.3810?guestAccessKey=90c1d87e-0a72-447a-b6a6-e9cdb9d39cbb&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=093024
END
Cardiac myosin inhibition in heart failure with normal and supranormal ejection fraction
JAMA Cardiology
2024-09-30
ELSE PRESS RELEASES FROM THIS DATE:
Amy Vandiver, MD, PhD, of UCLA receives the 2024 Sagol Network GerOmic Award for Junior Faculty
2024-09-30
NEW YORK — The American Federation for Aging Research (AFAR) is pleased to announce the recipient of the 2024 Sagol Network GerOmic Award for Junior Faculty: Amy Vandiver, MD, PhD, Clinical Instructor Clinician-Investigator Track, University of California Los Angeles. Established in 2020, the Sagol Network GerOmic Award for Junior Faculty is a one- to two-year award given to junior faculty (MDs and PhDs) to conduct aging-related Omics (GerOmics) research.
Omics is a rapidly evolving, multi-disciplinary, and emerging field that encompasses genomics, epigenomics, transcriptomics, ...
Post-mastectomy radiation therapy can be shortened by nearly half for patients planning breast reconstruction
2024-09-30
WASHINGTON, September 30, 2024 — An accelerated course of radiation therapy does not increase complications for patients who undergo breast reconstruction following a mastectomy, new research shows. Findings of the large, phase III RT CHARM trial (Alliance A221505) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
While radiation therapy following mastectomy to remove breast cancer is known to improve survival rates for certain patients who are at higher risk of recurrence, RT CHARM is the first multi-institutional international study to show that a shorter course ...
IMRT and proton therapy offer equally high quality of life and tumor control for people with prostate cancer
2024-09-30
WASHINGTON, September 30, 2024 — People with low- and intermediate-risk prostate cancer treated with either of two types of contemporary radiation therapy — proton beam therapy or intensity modulated radiation therapy (IMRT) — achieved equally high rates of tumor control with no differences in patient-reported quality of life, according to a first-of-its-kind phase III clinical trial comparing the two technologies. Findings of the PARTIQoL trial will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
“We tested two contemporary, advanced forms of external ...
Timing matters when adding immunotherapy to chemoradiation for patients with limited-stage small cell lung cancer
2024-09-30
WASHINGTON, September 30, 2024 — People with limited-stage small cell lung cancer may benefit from adding immunotherapy to chemoradiation, but not if both treatments are given at the same time, new research finds. The results suggest that the timing of when immunotherapy is given plays a key role in its ability to extend survival. Findings of the multi-institutional phase III trial, which also found that twice-daily radiation treatments offer greater survival benefits than once-daily treatment, will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
The ...
Existing standard chemoradiation superior to deintensification approaches for HPV-related oropharyngeal cancer
2024-09-30
WASHINGTON, September 30, 2024 — Researchers looking to de-intensify radiation treatments for people with early-stage, HPV-associated oropharyngeal cancer to prevent long-term side effects halted a large, randomized phase II/III trial after patients in the control arm reached a record high, two-year progression-free survival rate of 98%. De-intensified treatments involving a lower radiation dose and immunotherapy in place of chemotherapy did not perform as well as the more rigorous chemoradiation approach. Findings of the NRG Oncology HN005 trial will be presented today at the American Society for Radiation Oncology (ASTRO) Annual ...
CAR-T safe and effective on an outpatient basis in community hospitals
2024-09-30
(WASHINGTON – September 30, 2024) In the largest prospective study to date examining the use of chimeric antigen receptor (CAR)-T therapy in a community setting on an outpatient basis, patients with relapsed or refractory large B-cell lymphoma (LBCL) responded well to treatment with few serious side effects, according to results published today in Blood Advances.
LBCL is a cancer affecting B lymphocytes, a type of white blood cell. It can progress rapidly and is fatal if untreated, although most forms of LBCL respond well to standard ...
City of Hope to present leading-edge radiotherapy treatments for people with lung, genitourinary and blood cancers at the American Society for Radiation Oncology Annual Meeting
2024-09-30
LOS ANGELES — City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. and ranked among the nation’s top 5 cancer centers by U.S. News & World Report, is part of today’s press conference program at the American Society for Radiation Oncology (ASTRO) Annual Meeting, where a renowned City of Hope radiation oncologist will present phase 3 clinical trial data showing that people with limited-stage small cell lung cancer may benefit from adding immunotherapy to chemoradiation, but not if both treatments are given at the same time. The results suggest that the timing of when immunotherapy is given plays a key role in its ...
A new and unique fusion reactor comes together with PPPL's contributions
2024-09-30
Like atoms coming together to release their power, fusion researchers worldwide are joining forces to solve the world’s energy crisis. Harnessing the power of fusing plasma as a reliable energy source for the power grid is no easy task, requiring global contributions.
The Princeton Plasma Physics Laboratory (PPPL) — a U.S. national laboratory funded by the Department of Energy (DOE) — is leading several efforts on this front, including collaborating on the design and development of a new fusion device at the University of Seville in Spain. The SMall Aspect Ratio Tokamak (SMART) strongly ...
Reduced risk of serious cardiovascular disease after COVID vaccination
2024-09-30
People who have been fully vaccinated against COVID-19 have a significantly lower risk of developing more severe cardiovascular conditions linked to COVID-19 infection, according to a nationwide study at the University of Gothenburg. At the same time, some cardiovascular effects are seen after individual doses of the vaccine.
The COVID-19 vaccine aims to reduce complications and overall mortality from the disease. At the same time, some cardiovascular effects have been seen after individual doses of the vaccine. A rare acute side effect is inflammation of the cardiac muscle or the pericardium in young men following mRNA vaccination. In terms of other cardiovascular ...
New laser-based headset can measure blood flow, assess risk of stroke
2024-09-30
When physicians want to know more about a patient’s risk of cardiovascular disease, they can order a cardiac stress test. But when it comes to risk of stroke, there is no equivalent scalable and cost-effective test of the brain’s function to help physicians counsel patients on their potential risk. A questionnaire that asks patients about contributing risk factors is currently the best tool for estimating such risk.
Now a team of engineers and scientists from Caltech and the Keck School ...
LAST 30 PRESS RELEASES:
CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1
Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce
Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes
New research expands laser technology
Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain
A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers
Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes
CTE and normal aging are difficult to distinguish, new study finds
Molecular arms race: How the genome defends itself against internal enemies
Tiny chip speeds up antibody mapping for faster vaccine design
KTU experts reveal why cultural heritage is important for community unity
More misfolded proteins than previously known may contribute to Alzheimer’s and dementia
“Too much going on”: Autistic adults overwhelmed by non-verbal social cues
What’s driving America’s deep freezes in a warming world?
A key role of brain protein in learning and memory is deciphered by scientists
Heart attacks don’t follow a Hollywood script
Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories
Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds
Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%
Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR
New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications
State gun laws and firearm-related homicides and suicides
Use of tobacco and cannabis following state-level cannabis legalization
Long-term obesity and biological aging in young adults
Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement
Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development
A technological breakthrough for ultra-fast and greener AI
Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption
Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications
[Press-News.org] Cardiac myosin inhibition in heart failure with normal and supranormal ejection fractionJAMA Cardiology