Study uncovers the true burden of asthma in African pupils, highlighting need for better access to asthma diagnosis and care

(Press-News.org) Peer reviewed | Observational study | People 

Rapid urbanisation and population growth in sub-Saharan Africa has increased the incidence of asthma in young people, but the lack of diagnosis and care means that many young people are suffering from untreated symptoms of asthma, according to research from Queen Mary University of London.    

  The team who led the study, whose pioneering research on the impact of pollution on lung health was instrumental in introducing the Ultra Low-Emission Zone (ULEZ) in London, are calling for better access to asthma diagnosis and care in areas of rapid urbanisation and population growth.  



Asthma is the second most common cause of chronic respiratory deaths in the overall population of sub-Saharan Africa. The study led by researchers at Queen Mary and published today in The Lancet Child and Adolescent Health, is the first of its kind to determine the true prevalence and severity of asthma in undiagnosed, yet symptomatic young people in sub-Saharan Africa.  

The researchers recruited 20,000 school students between the ages of 12 and 14 from schools in urban areas in Malawi, South Africa, Zimbabwe, Uganda, Ghana, and Nigeria. The first part of the trial screened for asthma symptoms – of the 20,000 students, 12% of the participants reported symptoms of asthma, but of that group, only 20% had received a formal diagnosis of the condition.  

In the second part of the trial, the students who reported asthma symptoms were invited to complete a detailed questionnaire covering asthma control, current treatment, knowledge and perception of asthma, and barriers to achieving good control (including access to care and environmental factors). Researchers also carried out lung function tests, which are used as test to help asthma diagnosis. The study found that nearly half of undiagnosed participants with severe symptoms had positive diagnostic tests, making clinical asthma very likely.  

Using International Study of Asthma and Allergies in Childhood (ISAAC) criteria, severe asthma symptoms were reported by two-thirds of adolescents, and 80% had not previously been diagnosed. Even where participants already had an asthma diagnosis, over 30% with severe symptoms were not using any asthma medication.  

Concerningly, almost half of students with asthma symptoms were not able to access emergency medical care when it was needed. 45% of students with asthma symptoms had required emergency treatment within the previous year, with a similar proportion reporting that this had not been available to them. 

Professor Jonathan Grigg, Professor of Paediatric Respiratory and Environmental Medicine at Queen Mary University of London, said: “The vast majority of children with asthma can be well controlled with inhaled medications. Our study done in six urban areas in sub-Saharan Africa shows that a large proportion of children with asthma symptoms have no formal diagnosis and are therefore untreated. Health professionals, policy makers, and the pharmaceutical industry must work together to address this unmet need that has been under recognised for far too long.” 

Dr Rebecca Nantanda, ACACIA Principal Investigator for Uganda, Paediatrician and Senior Research Scientist, Makerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, said: “Undiagnosed and poorly controlled asthma greatly impacts on the physical and psychosocial well-being of the affected children and their caregivers. The high burden of severe undiagnosed asthma revealed by the ACACIA study requires urgent attention, including access to medicines and diagnostics.”  

Dr Gioia Mosler, Head of Global Health Group and Community Engagement at Queen Mary University of London and the study’s research manager, said: “If our data are generalisable, there are millions of adolescents with undiagnosed asthma symptoms in sub-Saharan Africa. To improve the poor state of asthma control in sub-Saharan Africa, potential solutions such as educational programmes, better diagnosis, and treatment and screening in schools should be considered.” 

Professor Chris Griffiths, Professor of Primary Care at Queen Mary and author on the paper, is a leading expert on the health impacts of air pollution, particularly in cities, on the health and development of children. We spoke to him about the importance of his research in the context of climate change ahead of COP28: https://youtu.be/4Jv2ucStBME 

 

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NOTES TO EDITORS  

 

Researchers from this study were from the following organisations: 

Queen Mary University of London 

Department of Child Health, School of Medical Sciences Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana 

Department of Medicine, Lagos State University College of Medicine, and Lagos State University Teaching Hospital, Ikeja Lagos, Nigeria  

Komfo Anokye Teaching Hospital, Kumasi, Ghana  

University of Zimbabwe Faculty of Medicine and Health Sciences, Harare, Zimbabwe  

Malawi Liverpool Wellcome Programme, Blantyre, Malawi  

Department of Paediatrics and Child Health, Nelson R Mandela School of Clinical Medicine, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa  

Makerere University Lung Institute, Makerere College of Health Sciences, Kampala, Uganda  

Department of Paediatrics & Child Health, Lagos State University Teaching Hospital, and College of Medicine, Ikeja, Lagos, Nigeria  

Education for Health Africa, Durban, South Africa 

 

Contact: 

Faustine Akwa 

Senior Media Relations Officer  

Queen Mary University of London   

Email: f.akwa@qmul.ac.uk or press@qmul.ac.uk   

 

Paper details:    

Victoria O Oyenuga, et al: “Asthma symptoms, severity, and control with and without a clinical diagnosis of asthma in early adolescence in sub-Saharan Africa: a multi-country, school-based, cross-sectional study.” Corresponding author: Professor Jonathan Grigg. Published in The Lancet Child and Adolescent Health.  

DOI: 10.1016/S2352-4642(24)00232-3 
Available after publication at:  https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(24)00232-3/fulltext  

Under strict embargo until 23:30 (UK time) on Monday 21 October 2024.  

 A copy of the paper is available upon request.  

Conflicts of interest:   

Prof O O Adeyeye is an unpaid convener for Lung Health Improvement Initiative. Prof C J Griffiths is an investigator in the Genes and Health Programme with funds from Alnylam Pharmaceuticals, Genomics, and a Life Sciences Industry Consortium of AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline Research and Development, Maze Therapeutics, Merck Sharp & Dohme, Novo Nordisk, Pfizer, and Takeda Development Centre Americas. Prof Jonathan Grigg is a National Institute for Health and Care Research Senior Investigator, and reports research grants from OM Pharma and Marinomed, honoraria from AstraZeneca, payment from OM Pharma as an Advisory Board member, gift of asthma equipment from Omron, donation of Investigational Medicinal Product from Marinomed and OM Pharma, and was commissioned by Hodge Jones & Allen Solicitors to provide medical evidence related to the inquest on an asthma death. All other authors declare no competing interests. 

Funded by:  

UK National Institute for Health and Care Research, and UK Medical Research Council. 

  

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