PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

High-performance inkjet print head enhances bioprinting productivity

Implementation of high-efficiency, low-heat bioprinting technology using piezoelectric thin film

High-performance inkjet print head enhances bioprinting productivity
2024-11-12
(Press-News.org) Bioprinting is a technology used to create three-dimensional structures, such as human tissues or organs, using bio-inks made of cells and hydrogels. However, conventional inkjet technology has difficulty dispensing bio-inks that are sensitive to temperature due to the heat generated during operation. Furthermore, conventional 3D bioprinting mainly utilizes simple syringe-type printing devices with a single needle, making it time-consuming to produce artificial organs like the brain, lungs, and heart.

The Bionics Research Center team, led by Dr. Byung Chul Lee at the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh), in collaboration with Dr. Seung-Hyup Baek’s team at the Electronic Materials Research Center and Professor Tae-Keun Kim’s team at Korea University (President Dong-Won Kim), has developed a bio-ink inkjet print head using the piezoelectric material PMN-PZT. This new print head is thinner but performs better than conventional designs. When applied, it enables the simultaneous dispensing of bio-ink at high resolution in multiple positions, significantly improving bioprinting productivity.

The research team developed a multi-nozzle inkjet print head using high-performance PMN-PZT thin films. This technology allows individual control of 16 ink ejection units arranged at 300 μm intervals, resulting in 16 times higher driving efficiency compared to than conventional methods. This enhancement boosts productivity and stability in bioprinting, reducing the production time for artificial organs.

In experiments, the team successfully printed hydrogels, a type of bio-ink, at a diameter of 32μm—half the size of conventional methods. The print speed achieved was 1.2 m/s, approximately 60 times faster than traditional methods. Additionally, the heat generation was reduced by 73.4%, keeping the temperature increase below 3.2 degrees Celsius during printing, ensuring a stable output environment. This allows for precise dispensing of high-viscosity materials and minimizes the deformation of temperature-sensitive bio-inks.

The PMN-PZT-based print head developed in this research can be utilized in organoid fields such as artificial organ transplants and drug toxicity evaluations, where thermal stability has been challenging. Furthermore, the operating temperature remains below 30 degrees Celsius, preventing the deformation of temperature-sensitive electronic materials and providing a stable printing environment. Therefore, it has the potential for broad application in various industries, including electronic components beyond the medical field.

Dr. Lee stated, “The new print head using PMN-PZT thin film material has enhanced the potential for high-resolution 3D organoid model production,” adding, “We plan to commercialize a 3D bioprinter capable of creating organs applicable for transplantation and toxicity evaluation by experimenting with various bio-inks such as gelatin.”

 

###

KIST was established in 1966 as the first government-funded research institute in Korea. KIST now strives to solve national and social challenges and secure growth engines through leading and innovative research. For more information, please visit KIST’s website at https://eng.kist.re.kr/

This research was supported by the Ministry of Science and ICT (Minister Sang Im Yoo) through KIST's Major Projects and the National Core Materials Research Project (NRF-2020M3D1A2101933) funded by the Ministry of Science and ICT (Minister Sang-Im Yoo). The research findings were published in the international journal Sensors and Actuators B: Chemical (IF 8.0, JCR field 0.7%).

END

[Attachments] See images for this press release:
High-performance inkjet print head enhances bioprinting productivity High-performance inkjet print head enhances bioprinting productivity 2 High-performance inkjet print head enhances bioprinting productivity 3

ELSE PRESS RELEASES FROM THIS DATE:

Opioid use disorder: Updated clinical practice guideline

2024-11-12
La version française suit Opioid use disorder: updated clinical practice guideline An updated evidence-based guideline aimed at helping clinicians and other health care providers manage patients with opioid use disorder recommends buprenorphine and methadone as first-line treatments. The guideline is published in CMAJ (Canadian Medical Association Journal). https://www.cmaj.ca/lookup/doi/10.1503/cmaj.241173 Opioid use and opioid use disorder are the leading causes of drug-related deaths worldwide, and Canada ...

Microneedle sensors for dermal interstitial fluid analysis

Microneedle sensors for dermal interstitial fluid analysis
2024-11-12
The rapid advancement in personalized healthcare has driven the development of wearable biomedical devices for real-time biomarker monitoring and diagnosis. Traditional invasive blood-based diagnostics are painful and limited to sporadic health snapshots. To address these limitations, microneedle-based sensing platforms have emerged, utilizing interstitial fluid (ISF) as an alternative biofluid for continuous health monitoring in a minimally invasive and painless manner. The team led by Wei Gao from California Institute of Technology providea a comprehensive overview of microneedle sensor technology, covering microneedle design, fabrication methods, ...

‘Sleepy cannabis’: first study to show cannabinol increases sleep

‘Sleepy cannabis’: first study to show cannabinol increases sleep
2024-11-12
Research by scientists at the University of Sydney has identified a constituent in the cannabis plant that improves sleep. Their report is the first to use objective measures to show the component, known as cannabinol (CBN), increases sleep in rats.  The study has been published in the leading journal Neuropsychopharmacology. “For decades, cannabis folklore has suggested that aged cannabis makes consumers sleepy via the build-up of CBN, however there was no convincing evidence for this,” said lead author on the study Professor Jonathon Arnold, ...

Mount Sinai team shows AI can detect serious neurologic changes in babies in the NICU using video data alone

Mount Sinai team shows AI can detect serious neurologic changes in babies in the NICU using video data alone
2024-11-12
A team of clinicians, scientists, and engineers at Mount Sinai trained a deep learning pose-recognition algorithm on video feeds of infants in the neonatal intensive care unit (NICU) to accurately track their movements and identify key neurologic metrics. Findings from this new artificial intelligence (AI)-based tool, published November 11 in Lancet’s eClinicalMedicine, could lead to a minimally invasive, scalable method for continuous neurologic monitoring in NICUs, providing critical real-time insights into infant health that have not been possible before. Every year, more than 300,000 ...

Jeffrey Popma, MD, joins CRF as Chief Scientific and Strategic Officer

2024-11-11
NEW YORK – November 11, 2024 – The Cardiovascular Research Foundation® (CRF®) proudly announces the appointment of Dr. Jeffrey Popma as Chief Scientific and Strategic Officer. A world-renowned leader in cardiovascular research, Dr. Popma will drive forward pivotal programs and initiatives that will shape CRF’s future and fuel innovation at the CRF® Clinical Trials Center (CTC). His leadership will be instrumental in the development of the recently launched Real-World Data and Outcomes Center, advancing CRF’s commitment to impactful ...

Seiber elevated to IEEE senior member

Seiber elevated to IEEE senior member
2024-11-11
Larry Seiber, an R&D staff member in the Vehicle Power Electronics group at the Department of Energy’s Oak Ridge National Laboratory, has been elevated to senior member of the Institute of Electrical and Electronics Engineers, or IEEE.  Senior member status requires extensive experience that reflects professional accomplishments. Only 10% of IEEE’s more than 450,000 members achieve this level.  Seiber has conducted decades of cutting-edge research in power electronics and electric machinery. He developed the hardware ...

Study sheds light on how BRCA1 gene mutations fuel breast cancer

2024-11-11
People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of them doesn’t function. For cancer-suppressor genes like BRCA1, researchers have long hypothesized that a single healthy copy could still guard against tumor development. Yet women with one harmful BRCA1 mutation are far more likely to develop breast cancer — a risk traditionally explained by a second mutation that arises later in life, damages the healthy copy of the gene, ...

A new wrinkle in turtles: Their genomes fold in a unique way, Iowa State researchers find

2024-11-11
AMES, Iowa – In their long strings of nucleotides, DNA molecules hold massive troves of genetic data providing instructions for how living organisms should function – the blueprint of life. How the blueprint is stored, however, impacts how it is read and used. As cells divide and replicate, DNA strands coiled around proteins – chromatin – are in tightly bundled chromosomes. After division, the chromosomes loosen and chromatin is less compact. How and where the chromatin fiber folds and ...

Adequate sleep significantly reduces the risk of hypertension in adolescents, according to new study

2024-11-11
Adolescents who meet the recommended guidelines of nine to 11 hours of sleep per day were shown to have a significantly lower risk of hypertension, according to a new study from UTHealth Houston.   Recently published in the Journal of the American Heart Association, the research revealed that adolescents had a 37% lower risk of developing incidents of high blood pressure by meeting healthy sleep patterns, and underscoring the importance of adequate sleep behavior. The research further explored the ...

Research spotlight: Uncovering the mechanisms behind T cell differentiation

2024-11-11
How would you summarize your study for a lay audience?  T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against viruses and intracellular pathogens, or TH2 cells, which fight against extracellular pathogens like bacteria and parasites. However, scientists haven’t fully understood whether infected tissue itself has any role in directing the optimal T cell differentiation in response ...

LAST 30 PRESS RELEASES:

Meteorite contains evidence of liquid water on Mars 742 million years ago

Self-reported screening helped reduce distressing symptoms for pediatric patients with cancer

Which risk factors are linked to having a severe stroke?

Opening borders for workers: Abe’s profound influence on Japan’s immigration regime

How skills from hospitality and tourism can propel careers beyond the industry

Research shows managers of firms handling recalls should review media scrutiny before deciding whether to lobby

New model system for the development of potential active substances used in condensate modifying drugs

How to reduce social media stress by leaning in instead of logging off

Pioneering research shows sea life will struggle to survive future global warming

In 10 seconds, an AI model detects cancerous brain tumor often missed during surgery 

Burden of RSV–associated hospitalizations in US adults, October 2016 to September 2023

Repurposing semaglutide and liraglutide for alcohol use disorder

IPK-led research team provides insights into the pangenome of barley

New route to fluorochemicals: fluorspar activated in water under mild conditions

Microbial load can influence disease associations

Three galactic “red monsters” in the early Universe

First ever study finds sexual and gender minority physicians and residents have higher levels of burnout, lower professional fulfillment

Astronomers discover mysterious ‘Red Monster’ galaxies in the early Universe

The secrets of fossil teeth revealed by the synchrotron: a long childhood is the prelude to the evolution of a large brain

Obesity-fighting drugs may reduce alcohol consumption in individuals with alcohol use disorder

Does AI improve doctors’ diagnoses? Study puts it to the test

Extreme weather accelerates nitrate pollution in groundwater

Burden of liver cancer attributable to hepatitis B and alcohol globally, in China, and for five sociodemographic index regions from 1990 to 2021

Lehigh partners with North Carolina A&T to enhance flood damage mapping with AI and advanced radar

2024 AAAS Kavli Science Journalism Award winners named

Collaborative of prominent academic institutions launches groundbreaking healthcare AI challenge

American Federation for Aging Research announces 2024 AFAR grants for junior faculty

Potential single-dose smallpox and mpox vaccine moves forward

Mass General Brigham Gene and Cell Therapy Institute names Spark Grant recipients

New discovery may lead to more effective treatment for cardiovascular disease

[Press-News.org] High-performance inkjet print head enhances bioprinting productivity
Implementation of high-efficiency, low-heat bioprinting technology using piezoelectric thin film