Age on the molecular level: showing changes through proteins
Comprehensive analysis of quantitative changes in various proteins due to aging
2024-11-15
(Press-News.org)
With the worldwide population aging at an unprecedented rate, the prevention of age-related diseases has become a prominent issue. It is important to comprehensively and quantitatively evaluate the changes that aging causes at the molecular level in the body. By doing so, it may be possible to pinpoint specific aging factors and suppress age-related diseases.
Addressing this problem, previously conducted research established an atlas of changes in major tissues from aging by determining the extent to which mRNA was produced within living cells. However, there has not been an atlas of changes in proteins associated with aging.
To fill this gap in research, a team led by Lecturer Masaki Takasugi and Professor Naoko Ohtani at Osaka Metropolitan University’s Graduate School of Medicine constructed a highly comprehensive database called the Mouse Aging Proteomic Atlas. They did so by analyzing the proteomes and transcriptomes of brain, artery, heart, kidney, liver, lung, skeletal muscle, and skin tissues of 6-, 15-, 24-, and 30-month-old mice, as well as extracellular matrix-enriched fractions of major tissues. Through this, it became possible to analyze the characteristics of protein groups affected by aging in major tissues and revealed proteins in the extracellular matrix that increased with age.
“By clarifying the changes in various tissues due to aging in detail with regard to the number of proteins that are directly linked to gene function, we have dramatically improved our understanding of the overall changes on the molecular level,” said Dr. Takasugi.
Professor Ohtani concluded, “The results of this research are expected to contribute to a better understanding of the changes that occur with age.”
The findings were published in Nature Communications.
###
About OMU
Established in Osaka as one of the largest public universities in Japan, Osaka Metropolitan University is committed to shaping the future of society through “Convergence of Knowledge” and the promotion of world-class research. For more research news, visit https://www.omu.ac.jp/en/ and follow us on social media: X, Facebook, Instagram, LinkedIn.
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2024-11-15
In crowdsourcing scenarios, we can obtain each instance's multiple noisy labels from different crowd workers and then infer its integrated label via label aggregation. In spite of the effectiveness of label aggregation methods, there still remains a certain level of noise in the integrated labels. Thus, some noise correction methods have been proposed to reduce the impact of noise in recent years. However, to the best of our knowledge, existing methods rarely consider an instance's information from both its features and multiple noisy labels simultaneously ...
2024-11-15
Peer-reviewed / Modelling study / People
Embargoed access to the paper and contact details for authors are available in Notes to Editors at the end of the release.
Most comprehensive US analysis of overweight and obesity at the national level and across all states and age groups estimates that obesity rates in adults (aged 25 or older) and older adolescents (aged 15-24 years) have at least doubled over the past three decades (1990-2021).
Southern states, including Oklahoma, Alabama, Arkansas, ...
2024-11-15
New research, led by experts at the University of Nottingham, has found that certain types of medication used to treat diabetes may be effective in reducing alcohol use.
The study, which is published in eClinicalMedicine, looked at whether a type of diabetes medication, called GLP-1 receptor agonists (GLP-1 RAs), could also be used to help people cut down on drinking.
The study was led by Dr Mohsen Subhani, Clinical Assistant Professor of Gastroenterology at the NIHR Nottingham Biomedical Research Centre, in the ...
2024-11-15
If every American over the age of 40 was as physically active as the top 25% of the population, they could expect to live an extra 5 years, on average, suggest the findings of a modelling study published online in the British Journal of Sports Medicine.
And if the least physically active matched the level of the most physically active, they could live almost 11 years longer, the estimates indicate.
It’s well known that low physical activity levels are associated with a higher risk of diseases, such as heart disease and stroke, as well as premature death, but it’s not clear to what extent low physical activity levels shorten lifespan in specific groups of people ...
2024-11-15
Hospitals must use artificial intelligence responsibly to avoid huge carbon emissions, new research has shown.
Released before Technology Day (Saturday, 16 November) at the COP29 climate conference in Baku, Azerbaijan, a study investigating the impact of artificial intelligence in healthcare has shown that using large language models to process thousands of patient records daily across multiple hospitals could lead to substantial resource consumption.
Published today (Friday, 15 November) in Internal Medicine Journal, researchers from the University ...
2024-11-14
SAN ANTONIO, Nov. 14, 2024 – The race to draw the best and brightest students has become an international one, with candidates weighing options not only in their state or country, but also across the globe. Universities likewise face fierce competition globally for top scientists and research funding.
The University of Texas Health Science Center at San Antonio (UT Health San Antonio) was ranked at the top 5% of universities in the world (No. 51 out of the top 1,000) in the U.S. News & World Report’s 2024-2025 Best Global Universities ...
2024-11-14
In 2021, the University of Arkansas School of Social Work partnered with the Fayetteville Police Department to pair officers with social workers trained to help people suffering mental crises. Initially, the officers were supportive of the effort but also somewhat hesitant. Now that the co-response teams are fully established, the officers say the program benefits the community and helps them carry out their duties.
The officers’ changing attitudes to the program were reported in the latest issue of the Journal of Police and Criminal Psychology. The paper was written by U of A social work professors Mark Plassmeyer and Kim Stauss, who helped launch and continue ...
2024-11-14
A new variant of human mpox has claimed the lives of approximately 5% of people with reported infections in the Democratic Republic of the Congo since 2023, many of them children. Since then, it has spread to several other countries. The World Health Organization declared the outbreak a Public Health Emergency of International Concern on August 14. In addition, a different but rarely fatal mpox variant was responsible for an outbreak that has spread to more than 100 countries since 2022.
There is an urgent need for faster and ...
2024-11-14
A multitude of genes have been linked to the development of Alzheimer’s disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.
Using cerebrospinal fluid (CSF) collected from living patients, a team of researchers at Washington University School of Medicine in St. Louis has for the first time linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer’s ...
2024-11-14
INDIANAPOLIS — An international, multidisciplinary team of leading neuro-oncology researchers and clinicians has released new recommendations for good clinical practice — a set of guidelines that helps ensure clinical trial results are reliable, and patients are protected — regarding the use of artificial intelligence methods to more accurately diagnose, monitor and treat brain cancer patients.
The team recently published two companion policy reviews in The Lancet Oncology, on behalf of the ...
LAST 30 PRESS RELEASES:
[Press-News.org] Age on the molecular level: showing changes through proteins
Comprehensive analysis of quantitative changes in various proteins due to aging
