Cardiometabolic trajectories preceding dementia in community-dwelling older individuals

JAMA Network Open

2025-02-07

(Press-News.org) About The Study: In this study of older individuals, decline in body mass index, waist circumference, and high-density lipoprotein (HDL) occurred up to a decade before dementia diagnosis. These findings provide insights into cardiometabolic changes preceding dementia and the potential for early monitoring and intervention.

Corresponding Author: To contact the corresponding author, Zimu Wu, PhD, email zimu.wu1@monash.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.58591)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.58591?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=020725

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Role of ELK3 in ferroptosis of rheumatoid arthritis fibroblast-like synoviocytes

2025-02-07

Background and objectives Rheumatoid arthritis (RA) is an inflammatory arthritis characterized by chronic joint inflammation, cartilage degradation, and bone erosion. ELK3 is a transcriptional repressor that can affect cell proliferation, migration, invasion, apoptosis, and other cellular processes. The study aimed to clarify the effect of ELK3 in the biological activity and ferroptosis phenotype of RA fibroblast-like synoviocytes (FLS), and to reveal its molecular mechanism in regulating ferroptosis in RA FLS. Methods We investigated the impact of ELK3 on the biological activity and ferroptosis phenotype of RA FLS using real-time quantitative polymerase chain reaction, immunohistochemistry, ...

Team of Prof. Woo Young Jang Department of Orthopedic Surgery, KU Anam Hospital wins the Best Paper Award from the Korean Musculoskeletal Tumor Society

2025-02-07

Professor Woo Young Jang (Department of Orthopedic Surgery, Korea University Anam Hospital) recently won the best paper award at the 2024 fall academic conference of the Korean Musculoskeletal Tumor Society held in November 22th, 2024. This award recognizes the outstanding results and academic value of the research led by Professor Jang. Professor Woo Young Jang, in collaboration with Professor Jun Seok Lee from the Department of Pharmacology and Dr. Jang Sun Hwang from the Department of Orthopedic Surgery at Korea University College of Medicine, conducted the research ‘Disaggregation-Activated ...

Terasaki Institute for Biomedical Innovation announces recipients of inaugural Keith Terasaki Mid-Career Innovation Award

2025-02-07

Los Angeles, CA – February 7, 2025 - The Terasaki Institute for Biomedical Engineering (TIBI) is pleased to announce their selection of Dr. Liangfang Zhang - Irwin Jacobs Chancellor’s Endowed Chair Professor at the University of California San Diego, and Dr. Aydogan Ozcan – Chancellor’s Professor, UCLA & Professor, Howard Hughes Medical Institute (HHMI), as the recipients of the inaugural Keith Terasaki Mid-Career Innovation Award. These awards will be presented at the 3rd Annual Terasaki Innovation Summit, to be held March ...

The impact of liver graft preservation method on longitudinal gut microbiome changes following liver transplant

2025-02-07

Background and Aims End-stage liver disease is associated with disruptions in gut microbiota composition and function, which may facilitate gut-to-liver bacterial translocation, impacting liver graft integrity and clinical outcomes following liver transplantation. This study aimed to assess the impact of two liver graft preservation methods on fecal microbiota and changes in fecal and breath organic acids following liver transplantation. Methods This single-center, non-randomized prospective pilot study enrolled liver transplant patients whose grafts were preserved using either static cold storage or ex situ normothermic machine perfusion (NMP). Fresh stool ...

Cardiovascular health risks continue to grow within Black communities, action needed

2025-02-07

DALLAS, Feb. 7, 2025 — The American Heart Association’s 2025 Heart Disease and Stroke Statistical Update reports that while progress has been made in reducing cardiovascular and cerebral health disparities, Black communities in the United States still face disproportionately higher risk of heart disease, stroke and hypertension. These gaps subsequently contribute to equally disproportionate high death rates, underscoring the urgent need for lifesaving intervention. As part of its nationwide Heart Month and Black History Month activations, the ...

ALS survival may be cut short by living in disadvantaged communities

2025-02-07

Living in a disadvantaged community may decrease the length of time a person can survive with amyotrophic lateral sclerosis, or ALS, by over 30%, a Michigan Medicine-led study suggests. ALS is a progressive, incurable condition that causes muscle wasting and loss of muscle control. While most people survive with ALS around two to four years, some people can live significantly longer. In the study of more than 1,000 patients with ALS seen between 2012 and mid-2024, people from the most disadvantaged neighborhoods had up to a 37% ...

No quantum exorcism for Maxwell's demon (but it doesn't need one)

2025-02-07

In a groundbreaking discovery, researchers from Nagoya University in Japan and the Slovak Academy of Sciences have unveiled new insights into the interplay between quantum theory and thermodynamics. The team demonstrated that while quantum theory does not inherently forbid violations of the second law of thermodynamics, quantum processes may be implemented without actually breaching the law. This discovery, published in npj Quantum Information, highlights a harmonious coexistence between the two fields, ...

Balancing the pressure: How plant cells protect their vacuoles

2025-02-07

Plants droop and shed their leaves when parched, but with a splash of water, their stems regain strength and their leaves unfurl. This dramatic transformation is a clear signal for us to reach for the watering can – and it demonstrates a delicate balance at the cellular level, which lies at the heart of plant’s rigidity. The structural support of a plant depends on the unique balance between two elements: The strong, flexible cell wall provides structural support, while the vacuole, a large cellular compartment filled with water, acts like a water balloon, pressing against the cell wall. The delicate pressure balance between the inside and the ...

Electronic reporting of symptoms by cancer patients can improve quality of life and reduce emergency visits

2025-02-07

CHAPEL Hill, N.C.—People with metastatic cancer who regularly report their symptoms via a home-based electronic monitoring system experienced improved quality of life, clinical outcomes and well-being, as well as fewer emergency department visits than those who didn’t file reports. Both groups had similar overall survival rates, according to University of North Carolina Lineberger Comprehensive Cancer Center researchers and their colleagues. The results from the national multicenter study appeared in Nature Medicine on Feb. 7. “Doctors and nurses are often ...

DNA barcodes and citizen science images map spread of biocontrol agent for control of major invasive shrub

2025-02-07

New CABI-led research using publicly-shared DNA barcodes and citizen science images have provided new evidence on the establishment and spread of a biological control agent used for the control of the major invasive shrub Lantana camara. Lantana camara was introduced as a garden and ornamental plant throughout the tropics and subtropics but is now pervasive throughout the Old World, invading woodlands, forestry, orchards, grasslands, and disturbed areas, where is displaces useful and indigenous plants. Dr Matthew Cock, CABI Emeritus Fellow, and colleagues took DNA barcodes from the Barcode of Life Data System (BOLD) and citizen ...

LAST 30 PRESS RELEASES:

Treating heart failure patients with anti-obesity medication reduces greenhouse gas emissions and improves clinical outcomes

Cardiac arrest in space: New research shows that automatic chest compressions are more effective for CPR when both rescuer and patient are floating in microgravity