Prothrombin complex concentrate vs frozen plasma for coagulopathic bleeding in cardiac surgery

JAMA

2025-03-29

(Press-News.org) About The Study: In this unblinded randomized clinical trial, prothrombin complex concentrate had superior hemostatic efficacy and safety advantages to frozen plasma among patients requiring coagulation factor replacement for bleeding during cardiac surgery.

Corresponding Author: To contact the corresponding author, Keyvan Karkouti, MD, email keyvan.karkouti@uhn.ca.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.3501)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being presented at the American College of Cardiology’s Annual Scientific Session.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.3501?guestAccessKey=4e76e8ef-73a1-44b9-b8e4-315cc6e46a6c&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032925

END

ELSE PRESS RELEASES FROM THIS DATE:

Who needs a statin? New study compares prescribing recommendations based on traditional risk factors vs. coronary artery calcium scoring

2025-03-29

A new study by researchers at Intermountain Health in Salt Lake City aims to determine the best method to screen and evaluate patients who are at risk of developing coronary heart disease and which patients would benefit from taking a statin medication to lower cholesterol. Currently, cardiologists determine a patient’s need for a statin based on traditional risk factors, using the Pooled Cohort Equation (PCE), which calculates coronary risk by assessing the risk factors of age, sex, total and HDL cholesterol levels, blood pressure, and whether someone ...

Finerenone and atrial fibrillation in heart failure

2025-03-29

About The Study: The efficacy of finerenone was consistent regardless of atrial fibrillation status in this study. New-onset atrial fibrillation was associated with a substantially higher risk of subsequent outcomes. Corresponding Author: To contact the corresponding author, John J. V. McMurray, MD, email john.mcmurray@glasgow.ac.uk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamacardio.2025.0848) Editor’s Note: Please see the article for additional information, including other authors, ...

Low coronary artery calcium score is associated with an excellent prognosis regardless of a person’s age, new study finds

2025-03-29

Having a coronary artery calcium (CAC) score of zero has generally been accepted as a marker of a very low risk of having a cardiac event within the next five years. However, age is a strong contributor to coronary risk, with risk increasing markedly as people age. Whether age-related risk factors diminish the low risk predicted by a zero coronary artery calcium score has been uncertain – until now. A large new study of more than 40,000 patients from heart researchers at Intermountain Health in Salt Lake City finds that a zero coronary artery calcium score continues to be an accurate indicator of a low risk for a coronary ...

Groundbreaking consensus statement on conduction system pacing released: a major milestone in the evolution of pacing therapy

2025-03-29

Vienna, 30 March 2025– The European Society of Cardiology (ESC) has released a groundbreaking consensus statement on conduction system pacing (CSP), marking a significant milestone in the evolution of pacing therapy. The document was officially presented today at the EHRA 2025 congress in Vienna and simultaneously published in EP Europace. For over 50 years, right ventricular pacing has been a standard treatment for slow heart rhythms. However, in some patients, this approach can lead to reduced heart function and even heart failure. Furthermore, biventricular pacing ...

Nuclear monitoring system suggests landslide cut off internet in west Africa

2025-03-29

Hydroacoustic signals captured by the world’s international nuclear monitoring system suggest an underwater landslide may have broken communications cables and disrupted internet traffic in west African countries for several weeks in March 2024. Researchers used data collected by hydrophones installed by the International Monitoring System of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) to determine the location of the possible landslide, placing it along the steep slopes of Trou Sans Fond Canyon offshore of Ivory Coast. The proposed landslide corresponds with the timing and location of four broken cables in the canyon, according to Vaibhav Vijay Ingale of UC ...

PNNL scientist elected AAAS fellow

2025-03-29

RICHLAND, Wash.—Chemist Zheming Wang, whose research largely focuses on the chemistry underlying radioactive and advanced energy materials, as well as critical elements, has been elected as a Fellow of the American Association for the Advancement of Science—the highest honor the society bestows. AAAS is the world's largest multidisciplinary scientific society with a mission to “advance science, engineering, and innovation throughout the world for the benefit of all people.” AAAS notes that Fellows are celebrated for contributions that span ...

American College of Cardiology recognizes five JACC Rocket Fuel Consultants

2025-03-28

The American College of Cardiology will honor five cardiovascular experts with the JACC Rocket Fuel Consultant Award for fueling JACC’s mission to provide high-quality, pertinent research and improve heart health for all. The awardees will be recognized during ACC’s Annual Scientific Session (ACC.25) in Chicago. This is the first year of the JACC Rocket Fuel Consultant Award. The JACC consultant program invites experts to provide comprehensive assessments of a submission’s quality, importance and impact. Their contributions streamline the review process and ensure that JACC maintains its commitment to high-quality research. The 2025 JACC Rocket ...

American College of Cardiology, Association of Black Cardiologists recognize three Merck Research Fellowship awardees

2025-03-28

The American College of Cardiology and the Association of Black Cardiologists have selected three recipients of the Merck Research Fellowship Award, fostering the next generation of cardiovascular investigators. Awardees will be recognized during the American College of Cardiology’s Annual Scientific Session (ACC.25) in Chicago. The ACC/ABC Merck Research Fellowship provides three, one-year fellowships totaling $100,000 to support one year of cardiovascular research. The year of research began in December 2024 and will run through December 2025. This year’s recipients and their research titles are: Temidayo ...

JACC to recognize 2025 Simon Dack Award recipients, Elite Reviewers

2025-03-28

JACC, the flagship journal of the American College of Cardiology, has awarded two peer reviewers with the Simon Dack Award for Outstanding Scholarship and seven peer reviewers with Elite Reviewer awards. Named after the founding editor of JACC, the Simon Dack Award recognizes outstanding peer reviewers whose contributions have helped JACC achieve its mission to publish new and important clinical research. The 2025 recipients are: Kershaw V. Patel, MD, Houston Methodist Hospital, Houston Robert S. Rosenson, MD, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York The Elite Reviewers are peer reviewers ...

American College of Cardiology honors two recipients with the William A. Zoghbi Global Research Initiative Award

2025-03-28

This year, the American College of Cardiology will recognize Jennifer Mateo Soto, MD, and Opeyemi Olalekan Oni, MBBS, MSc, with the William A. Zoghbi Global Research Initiative Award. The awardees will be honored during ACC’s Annual Scientific Session (ACC.25) in Chicago. First established in 2023, the William A. Zoghbi Global Research Initiative fosters innovations in cardiovascular research and aims to improve the care of people in low- to middle-income countries who at risk of or living with cardiovascular disease. Recipients of the award receive $25,000 to put toward an ...

Liver transplantation utilizing grafts donated after medical assistance in dying is feasible and has outcomes comparable to standard donation

New drug-eluting balloon may be as safe and effective as conventional metal stents for repeat percutaneous coronary interventions

Effectiveness and cost-effectiveness of automated external defibrillators in private homes

University of Phoenix College of Social and Behavioral Sciences leadership publishes white paper on trauma-informed education

Identifying the best high-biomass sorghum hybrids based on biomass yield potential and feedstock quality affected by nitrogen fertility management under various environments

Prothrombin complex concentrate vs frozen plasma for coagulopathic bleeding in cardiac surgery

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: