Postpartum hormonal contraceptive use and risk of depression

JAMA Network Open

2025-03-31

(Press-News.org) About The Study: Hormonal contraceptive initiation postpartum was associated with an instantaneous increased risk of developing depression in this cohort study. The associated risk was higher the earlier it was initiated postpartum, at least for combined oral contraceptives. This finding raises the issue of whether the incidence of depression postpartum is increased by routine hormonal contraceptive initiation after childbirth.

Corresponding Author: To contact the corresponding author, Vibe Gedsø Frokjaer, PhD, email vibe.frokjaer@nru.dk.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.2474)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Postpartum hormonal contraceptive use and risk of depression

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