(Press-News.org) A team of scientists from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has identified a promising new drug target for acute myeloid leukemia (AML), a deadly blood cancer with a five-year survival rate of just 30%, according to the National Cancer Institute. Their study, published in Cell Stem Cell in February, highlights the crucial role of a protein called paraspeckle component 1 (PSPC1) in the progression of AML.
An aggressive blood cancer, AML originates in the bone marrow and is known to disrupt the normal production of blood cells. Treatment is difficult because patients may not respond to chemotherapy or experience a relapse of the disease.
“AML is highly diverse, with more than 70 known driver mutations,” said Mingjiang Xu, PhD, professor of molecular medicine at the Joe R. and Teresa Lozano Long School of Medicine and CTRC Council Distinguished Chair in Oncology at UT Health San Antonio’s Mays Cancer Center. “Even targeted therapies like IDH inhibitors can only treat a small subset of AML patients. Given this diversity, we need a uniform, one-for-all drug target to effectively treat AML.”
Xu is one of the study’s primary investigators. Co-primary investigators include Feng-Chun Yang, MD, PhD, a tenured professor in the Department of Cell Systems and Anatomy, A.B. Alexander Distinguished Chair in Cancer Research, Mays Cancer Center and Jianlong Wang, PhD, Columbia University Irving Medical Center.
In mouse models, depleting PSPC1 significantly delayed AML progression and improved survival rates. Removing PSPC1 inhibited cancer cell growth without affecting normal blood cell formation. Xu suggests that targeting PSPC1 could provide a new treatment for AML.
PSPC1 has been found in 21 different cancer cell lines, primarily in solid tumors, playing a role in worsening or advancing the disease more quickly. This suggests that therapies targeting PSPC1 could have broader applications in oncology, beyond just AML. Researchers are now investigating methods to selectively inhibit PSPC1 in cancer cells while preserving its function in normal cells, potentially offering a targeted treatment with fewer side effects.
Xu states the next step is to test potential drugs that could inhibit PSPC1, significantly impacting not only AML, but also solid tumors like lung and prostate cancer by preventing metastasis, offering new hope for cancer patients.
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The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is one of the country’s leading health science universities and is designated as a Hispanic-Serving Institution by the U.S. Department of Education. With missions of teaching, research, patient care and community engagement, its schools of medicine, nursing, dentistry, health professions, graduate biomedical sciences and public health have graduated more than 43,771 alumni who are leading change, advancing their fields and renewing hope for patients and their families throughout South Texas and the world. To learn about the many ways “We make lives better®,” visit UTHealthSA.org.
Stay connected with The University of Texas Health Science Center at San Antonio on Facebook, Twitter, LinkedIn, Instagram and YouTube.
The Mays Cancer Center at UT Health San Antonio is one of only four National Cancer Institute-designated Cancer Centers in Texas. The Mays Cancer Center provides leading-edge cancer care, propels innovative cancer research and educates the next generation of leaders to end cancer in South Texas. In 2017, Mays Cancer Center became one of a select few centers in the nation to partner with MD Anderson Cancer Center, expanding access to cancer treatments that are among the most advanced in the nation–close to home. To learn more, visit https://cancer.uthscsa.edu.
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New research finds novel drug target for acute myeloid leukemia, bringing hope for cancer patients
2025-04-01
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