PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Research Spotlight: understanding sudden unusual mental or somatic experiences

2025-04-28
(Press-News.org) How would you summarize your study for a lay audience?

Our team has been investigating unusual mental and somatic experiences that occur in intensive meditative, spiritual and contemplative practice, such as:

The sense that the world is a dream or cartoon An absorbing sense of unity with God Ecstatic thrills running through the body Unusually vivid perceptions Out of body experiences Perceptions of non-physical lights. In a previous study, we found these experiences were surprisingly widespread in general populations, and that while they are usually followed by positive changes to wellbeing, sometimes they lead to clinically relevant suffering.

In this study, we applied epidemiological techniques to identify risk factors for the occurrence of these unusual experiences and subsequent suffering.

We found clear results that can help to predict when these phenomena might emerge in individuals, guide practitioners seeking to obtain or avoid these experiences, and enable clinicians to better differentiate between psychosis and events more often associated with contemplative or spiritual practice.

What methods or approach did you use?

We used an expert panel to develop a questionnaire that measured past occurrence of these events and subsequent suffering, as well as a variety of potential covariates including spiritual or contemplative practice histories, personal characteristics, and demographics.

We gathered data through three surveys of general populations across two countries (total study participants = 3133) and applied logistic regression to identify risk factors.

What did you find?

While unusual mental and somatic experiences are well known amongst contemplative and spiritual practitioners, they are usually reported by anecdote rather than formal measurement. They are understudied in the scientific literature and under-represented in both the DSM and clinician training.
In our study, we found very high increases in risk for these experiences associated with past psychedelic use, reality distorting practices (divine or occult practices, and contemplation of mysteries) and the total hours spent in spiritual or meditative practice outside retreats.

There were lesser but still considerable effects for other variables, including having had a traumatic or spiritually powerful childbirth experience and past diagnosis of mental illness.

For occurrence alone, but not for subsequent suffering, some traditional eastern meditative practices were risk factors while prayer was a protective factor.

What are the implications?

Clinicians can use these results to assist in the diagnosis; the presence or absence of relevant risk factors may help to distinguish between spiritual difficulties and psychosis, better guiding treatment response to patients.

For those promoting the use of psychedelics for contemplative practice or medical intervention, these results provide the first direct evidence of links to the potential for subsequent suffering. Psychedelic research protocols ought to take account of these longer-term risks to participants.

What are the next steps?

We hope our findings will contribute to the formation of the next set of DSM guidelines.

We are open to working with clinicians, as well as contemplative and spiritual teachers, to translate our results into practical guidelines for managing risk factors, diagnosing associated suffering, and treatment of symptoms.

We will also extend our work to investigate the risk factors for positive changes to wellbeing, as these are the more commonly reported aftereffects of unusual mental and somatic experiences.

As the research has been conducted on cross-sectional data, it would be useful to undertake longitudinal studies to better investigate causal links between the factors and outcomes that we have studied.

END


ELSE PRESS RELEASES FROM THIS DATE:

Bacteria’s mysterious viruses can fan flames of antibiotic damage, according to new model

2025-04-28
Some things just go together in your belly: peanut butter and jelly, salt and pepper, bacteria and bacteria-eating viruses. For the bacterial species that inhabit your gut, there’s a frenzy of viruses called bacteriophages that naturally infect them. Although they co-evolved with bacteria, phages get far less glory. They’re harder to classify and so deeply entangled with the bacteria they target that scientists struggle to understand what functions they serve. But what if there was a way to compare the exact same gut microbiome ...

All-cause mortality and life expectancy by birth cohort across US states

2025-04-28
About The Study: Cohort-specific patterns across states reveal wide disparities in mortality. Some states have experienced little or no improvements in life expectancy from the 1900 to 2000 birth cohorts. Understanding how mortality patterns vary by birth cohort within each state can inform decision-making around resource allocation and public health interventions. Corresponding Author: To contact the corresponding author, Theodore R. Holford, PhD, email theodore.holford@yale.edu. To ...

Trends in maternal, fetal, and infant mortality in the US, 2000-2023

2025-04-28
About The Study: The results of this study suggest that maternal health was difficult to track due to changes in reporting practices, but public health emergencies such as the COVID-19 pandemic can have large negative impacts. Corresponding Author: To contact the corresponding author, Seth Flaxman, PhD, email seth.flaxman@cs.ox.ac.uk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2025.0440) Editor’s Note: Please see the article for additional information, including other authors, ...

Children with liver disease face dramatically higher risk of early death

2025-04-28
Researchers from University of California San Diego have found that children diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD) are at significantly increased risk of premature death and serious long-term health complications. The findings, published April 22, 2025 in Hepatology, the scientific journal of the American Association for the Study of Liver Diseases, come from the Longitudinal InVestigation Evaluating Results of Steatosis (LIVERS) study, which followed 1,096 children over an average of 8.5 years. Nearly half of all deaths in the cohort were liver-related, and the overall mortality rate was 40 times higher than that ...

10x Genomics and Ultima Genomics partner with Arc Institute to accelerate development of the Arc Virtual Cell Atlas

2025-04-28
Arc Institute continues its work to generate and share large-scale, high-quality datasets of cell state before and after chemical or genetic perturbations to enable “virtual cell” models and other innovations. Two months after launching the Arc Virtual Cell Atlas comprising over 300 million cells, the initiative is now benefiting from new partnerships with 10x Genomics and Ultima Genomics, industry leaders in advanced tools that make collecting single cell data faster, more scalable, and more affordable for scientists working to improve human ...

Data collection changes key to understanding maternal mortality trends in the US, new study shows

2025-04-28
A new study led by researchers at the University of Oxford, published today (28 April) in JAMA Pediatrics, offers fresh insight into trends in maternal mortality in the United States. For the first time, the study disentangles genuine changes in health outcomes from shifts caused by how deaths are recorded. Nevertheless, the study confirms the devastating impact of the COVID-19 pandemic on maternal death rates for women of all racial and ethnic groups. The study, based on data from 2000 to 2023, investigated how the introduction of a ‘pregnancy checkbox’ ...

Early immune evasion found in HPV-related pre-cancer lesions of the anogenital region

2025-04-28
“This study demonstrated that the inflammatory response in a subset of anal, penile, and vulvar HSILs was associated with PD-L1 and FOXP3 expression.” BUFFALO, NY – April 28, 2025 – A new research paper was published in Oncotarget, Volume 16, on April 24, 2025, titled “PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region.” Researchers Humberto Carvalho Carneiro, Rodrigo de Andrade Natal, José Vassallo and Fernando Augusto Soares from the Instituto D’Or de Pesquisa e Ensino and Rede D’Or studied ...

The role of gamma knife radiosurgery in the management of grade 2 meningioma

2025-04-28
Background and objectives The role of radiosurgery in the treatment of grade 2 meningioma remains unclear. This study aimed to evaluate the long-term outcomes of gamma knife radiosurgery (GKRS) in patients with grade 2 meningiomas and to identify factors influencing tumor control and survival. Methods In this retrospective study, seventy patients underwent GKRS for grade 2 meningioma between 2007 and 2016. Tumor recurrence was categorized as local, marginal, or distant. Survival curves were estimated using the Kaplan-Meier method, while the log-rank test and Cox proportional ...

Don’t resent your robot vacuum cleaner for its idle hours – work it harder!

2025-04-28
At a time when we run ourselves ragged to meet society’s expectations of productivity, performance and time optimisation, is it right that our robot vacuum cleaners and other smart appliances should sit idle for most of the day? Computer scientists at the University of Bath in the UK think not. In a new paper, they propose over 100 ways to tap into the latent potential of our robotic devices. The researchers say these devices could be reprogrammed to perform helpful tasks around the home beyond ...

Natural killer cells remember and effectively target ovarian cancer

2025-04-28
Researchers at Karolinska Institutet have uncovered a unique ability of a special subtype of natural killer cells in the immune system, called adaptive NK cells, to remember ovarian tumours and effectively attack them. The discovery, published in Cancer Immunology Research, could pave the way for new, more powerful immunotherapies for difficult-to-treat cancers. NK cells, or natural killer cells, are white blood cells that play a central role in the body’s defence against viral infections and cancer. NK cells can identify and destroy unhealthy-looking cells, such as tumour cells, without prior exposure. Adaptive ...

LAST 30 PRESS RELEASES:

ESC launches guidelines for patients to empower women with cardiovascular disease to make informed pregnancy health decisions 

Towards tailor-made heat expansion-free materials for precision technology

New research delves into the potential for AI to improve radiology workflows and healthcare delivery

Rice selected to lead US Space Force Strategic Technology Institute 4

A new clue to how the body detects physical force

Climate projections warn 20% of Colombia’s cocoa-growing areas could be lost by 2050, but adaptation options remain

New poll: American Heart Association most trusted public health source after personal physician

New ethanol-assisted catalyst design dramatically improves low-temperature nitrogen oxide removal

New review highlights overlooked role of soil erosion in the global nitrogen cycle

Biochar type shapes how water moves through phosphorus rich vegetable soils

Why does the body deem some foods safe and others unsafe?

Report examines cancer care access for Native patients

New book examines how COVID-19 crisis entrenched inequality for women around the world

Evolved robots are born to run and refuse to die

Study finds shared genetic roots of MS across diverse ancestries

Endocrine Society elects Wu as 2027-2028 President

Broad pay ranges in job postings linked to fewer female applicants

How to make magnets act like graphene

The hidden cost of ‘bullshit’ corporate speak

Greaux Healthy Day declared in Lake Charles: Pennington Biomedical’s Greaux Healthy Initiative highlights childhood obesity challenge in SWLA

Into the heart of a dynamical neutron star

The weight of stress: Helping parents may protect children from obesity

Cost of physical therapy varies widely from state-to-state

Material previously thought to be quantum is actually new, nonquantum state of matter

Employment of people with disabilities declines in february

Peter WT Pisters, MD, honored with Charles M. Balch, MD, Distinguished Service Award from Society of Surgical Oncology

Rare pancreatic tumor case suggests distinctive calcification patterns in solid pseudopapillary neoplasms

Tubulin prevents toxic protein clumps in the brain, fighting back neurodegeneration

Less trippy, more therapeutic ‘magic mushrooms’

Concrete as a carbon sink

[Press-News.org] Research Spotlight: understanding sudden unusual mental or somatic experiences