PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

HonorHealth Research Institute presents new findings in decades-long quest to conquer aggressive pancreatic cancer

Promising results of RMC-6236, in combination with other drug treatments, presented at annual meeting of AACR

2025-04-29
(Press-News.org) PHOENIX, Ariz. — April 30, 2025 — HonorHealth Research Institute’s new downtown Phoenix laboratory has produced its first study, centered on a promising new treatment for pancreatic cancer, one of the most aggressive and difficult to treat of all malignancies.

Study results were presented April 29 in Chicago at the annual meeting of the 58,000-member American Association for Cancer Research (AACR), the world’s largest professional organization of cancer investigators, caregivers and patient advocates.

Study findings indicate that a newly discovered drug, RMC-6236, also known as Daraxonrasib, is a powerful inhibitor of RAS (including KRAS, NRAS and HRAS). These are commonly mutated cancer-causing genes that drive the formation of many types of tumors, including pancreatic cancer.  This study evaluated the effectiveness of RMC-6236 in patient-derived pancreatic tumors harboring KRAS mutations.

New: Center for Translational Science

According to this initial study to emerge from the Research Institute’s new Center for Translational Science laboratory, RMC-6236, when combined with other proven pancreatic cancer drugs, is a promising new agent against RAS, particularly KRASG12X. Existing KRASG12C inhibitors are unable to target other mutations and often have the unintended result of making  patient tumors drug resistant.

“The fibrotic tumor microenvironment in pancreatic cancer exacerbates therapy resistance, and combining RMC-6236 with other therapies could overcome both intrinsic and acquired resistances,” according to Taylor Bargenquast, a clinical research technician and lead author of the study abstract, which she presented at AACR.

“These results demonstrate the efficacy of RMC-6236 when combined with other therapeutic agents in a pancreatic cancer model — a three dimensional model of pancreatic cancer cells derived from patient biopsies,” said Sunil Sharma, M.D., director of the Center for Translational Science and the senior author of the study abstract.

“The combination of RMC-6236 with standard chemotherapy and targeted therapies enhances its antitumor activity, suggesting a promising strategy for improving therapeutic outcomes in pancreatic cancer,” said Erkut Borazanci, M.D., another of the study’s authors, and medical director of the Institute’s Oncology Research Division.

52,000 Americans expected to die

Pancreatic cancer is the third-leading cause of cancer-related death in the U.S., after lung and colorectal cancers, and is expected to contribute this year to the deaths of nearly 52,000 Americans.

Contributing to this study — Evaluating the efficacy of RAS(ON) inhibitor RMC-6236 combined with chemotherapy and other targeted therapies in 3D models involving patients with KRAS-mutated pancreatic cancer — was the Phoenix-based Translational Genomics Research Institute (TGen), part of City of Hope.

The study suggests that human clinical trials are warranted to further evaluate the safety and effectiveness of RMC-6236.

For more about HonorHealth Research Institute clinical trials: call 833-354-6667; or emailclinicaltrials@Honorhealth.com.

# # #

About the HonorHealth Research Institute
HonorHealth Research Institute is an international destination that is at the forefront of providing patients with a better quality of life through its clinical trials and innovative treatment options. Headquartered in Scottsdale, Arizona, the institute’s team of physicians and researchers collaborate with experts from across the nation to offer life-changing therapies, drugs and devices. At HonorHealth Research Institute, patients have access to tomorrow’s health innovations, today. Learn more at: HonorHealth.com/research.
 

END


ELSE PRESS RELEASES FROM THIS DATE:

HonorHealth Research Institute is the first of 50 sites worldwide to treat a patient in a new clinical study aimed at melanoma

2025-04-29
SCOTTSDALE, Ariz. — April 29, 2025 — HonorHealth Research Institute recently treated the first patient in a 50-site international clinical trial that will test a new type of therapy aimed at difficult-to-treat melanoma, an aggressive type of skin cancer. This new therapy targets PRAME, a peptide commonly found in melanoma tumors. The therapy uses the patient’s own manufactured and enhanced immune system T cells to create billions of new patient specific cells to attack melanoma, even after the cancer has spread to other parts of the body. “We are excited about the potential of this new type of cellular therapy,” said Justin Moser, M.D., an associate ...

Surviving cancer, still suffering: Survey reveals gaps in follow‑up care

2025-04-29
Over 70% said mental health was not addressed during treatment Less than a third had information about survivorship care Northwestern oncologists are launching new survivorship clinic based on findings Findings apply broadly to survivors of many cancers CHICAGO --- More Americans are beating cancer than ever, yet many still grapple with treatment’s long shadow — especially on their mental health. A new Northwestern Medicine study found most head-and-neck cancer survivors who underwent ...

A scientific method for flawless cacio e pepe

2025-04-29
WASHINGTON, April 29, 2025 – The beloved Italian pasta cacio e pepe is perhaps best known for two things: being delicious and being frustratingly difficult to cook. At first glance, it looks like a simple recipe, containing only three ingredients: pasta, pecorino romano cheese, and black pepper. But as anyone who has tried to make it will know, the cheese will often clump when added to the hot pasta water, turning what is supposed to be a smooth, creamy sauce into a stringy, sticky mess. In Physics of Fluids, by AIP Publishing, researchers from the University of Barcelona, the Max Planck Institute for the Physics of Complex Systems, the University of Padova, and the Institute of Science ...

Uptake of and disparities in semaglutide and tirzepatide prescribing for obesity in the US

2025-04-29
About The Study: Semaglutide and tirzepatide prescriptions within Epic-affiliated health care systems increased slightly between 2021 and 2024, but their uptake remained limited, with only 3% of eligible patients having ever received a prescription during that period. Furthermore, there were disparities in prescribing of varying magnitude based on race and ethnicity, social vulnerability, and urbanicity, although the absolute differences were small compared with the overall underutilization. Corresponding Author: To contact the corresponding author, Yuan Lu, ScD, email y.lu@yale.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.4735) Editor’s ...

Bridging the AI gap in medicine: new framework targets family doctor education

2025-04-29
(Toronto, April 28, 2025) A team of Canadian researchers has developed a curriculum framework to help train future family physicians in the use of artificial intelligence (AI), addressing a critical gap in medical training as digital tools become more common in patient care. Published in JMIR Medical Education, the study, “Curriculum Framework for AI Training in Postgraduate Family Medicine Education (AIFM-ed): Mixed Methods Study,” introduces the AIFM-ed framework to guide the integration of AI into family medicine training programs. As the health care system evolves, many medical professionals feel unprepared for the growing influence of AI in diagnostics, treatment, ...

Prenatal and perinatal factors of life’s essential 8 cardiovascular health trajectories

2025-04-29
About The Study: Pre-pregnancy overweight or obesity, smoking during pregnancy, and formula-feeding in the first 6 months of life were each associated with adverse cardiovascular health trajectories early in life in this cohort study. Future work should examine whether interventions that address these factors would be effective in optimizing cardiovascular health in children. Corresponding Author: To contact the corresponding author, Izzuddin M. Aris, PhD, email izzuddin_aris@hphci.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.7774) Editor’s ...

Maternal hypertension and adverse neurodevelopment in a cohort of preterm infants

2025-04-29
About The Study: In this preterm cohort study, maternal hypertensive disorders of pregnancy were independently associated with adverse cognitive and language development, with accentuated associations observed in preeclampsia-exposed preterm infants, emphasizing the clinical importance of recognizing hypertensive disorders of pregnancy as a risk, enabling targeted risk management strategies for closer monitoring and aggressive early intervention in affected populations. Corresponding Author: To contact the corresponding author, Nehal A. Parikh, DO, MS, email nehal.parikh@cchmc.org. To access the embargoed study: Visit our For The Media website at this ...

Menstrual cycle length changes following vaccination against influenza alone or with COVID-19

2025-04-29
About The Study: In this cohort study of individuals with regular menstrual cycles, influenza vaccine given alone or in combination with a COVID-19 vaccine was associated with a small but temporary change in menstrual cycle length. These findings may help clinicians confirm the utility of vaccination for patients with concerns about menstrual adverse effects of vaccination. Corresponding Author: To contact the corresponding author, Alison Edelman, MD, MPH, email edelmana@ohsu.edu. To access the embargoed study: ...

Study suggests dance and lullabies aren’t universal human behaviors

2025-04-29
Social singing and dance are often assumed to be hard-wired into the human condition; studies have supported the conclusion that these are common across cultures. But new research from a University of California, Davis, anthropologist challenges the idea that dance and lullabies are universal among humans. The study, published April 29 in Current Biology, draws on 43 years of research with the Northern Aché, an Indigenous population in Paraguay. “Aside from church singing introduced by missionaries, Northern Aché adults sing alone and in a limited number of contexts,” said study author Manvir Singh, an assistant ...

Feeling stressed may lead to worsened respiratory symptoms, decreased quality of life

2025-04-29
Miami (April 29, 2025) – Increased perceived stress may cause worsened respiratory symptoms and decreased quality of life in people with chronic obstructive pulmonary disease (COPD), according to a new study. The study is published in the March 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open-access journal. Perceived stress is used to describe how overwhelmed or stressed a person feels based on their personal understanding of the situation. It is a psychosocial factor, along with loneliness, social isolation and emotional support, which have been shown to impact health outcomes in ...

LAST 30 PRESS RELEASES:

Scientists shoot lasers into brain cells to uncover how illusions work

Your ecosystem engineer was a dinosaur

New digital cognitive test for diagnosing Alzheimer's disease

Parents of children with health conditions less confident about a positive school year

New guideline standardizes consent for research participants in Canada

Research as reconciliation: Oil sands and health

AI risks overwriting history and the skills of historians have never been more important, leading academic outlines in new paper

The Lancet Diabetes & Endocrinology: Higher doses of semaglutide can safely enhance weight loss and improve health for adults living with obesity, two new clinical trials confirm

Trauma focused therapy shows promise for children struggling with PTSD

School meals could drive economic growth and food system transformation

Home training for cerebellar ataxias

Dry eyes affect over half the general population, yet only a fifth receive diagnosis and treatment

Researchers sound warning about women with type 2 diabetes taking oral HRT

Overweight and obesity don’t always increase the risk of an early death, Danish study finds

Cannabis use associated with a quadrupling of risk of developing type 2 diabetes, finds study of over 4 million adults

Gestational diabetes linked to cognitive decline in mothers and increased risk of developmental delays, ADHD and autism among children

Could we use eye drops instead of reading glasses as we age?

Patients who had cataracts removed or their eyesight corrected with a new type of lens have good vision over all distances without spectacles

AI can spot which patients need treatment to prevent vision loss in young adults

Half of people stop taking popular weight-loss drug within a year, national study finds

Links between diabetes and depression are similar across Europe, study of over-50s in 18 countries finds

Smoking increases the risk of type 2 diabetes, regardless of its characteristics

Scientists trace origins of now extinct plant population from volcanically active Nishinoshima

AI algorithm based on routine mammogram + age can predict women’s major cardiovascular disease risk

New hurdle seen to prostate screening: primary-care docs

MSU researchers explore how virtual sports aid mental health

Working together, cells extend their senses

Cheese fungi help unlock secrets of evolution

Researchers find brain region that fuels compulsive drinking

Mental health effects of exposure to firearm violence persist long after direct exposure

[Press-News.org] HonorHealth Research Institute presents new findings in decades-long quest to conquer aggressive pancreatic cancer
Promising results of RMC-6236, in combination with other drug treatments, presented at annual meeting of AACR