Immunogenicity and safety of influenza and COVID-19 multicomponent vaccine in adults age 50 and older

JAMA

2025-05-07

(Press-News.org) About The Study: In this phase 3 study, mRNA-1083, an investigational, multicomponent vaccine against seasonal influenza and SARS-CoV-2, met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64), the 3 clinically relevant influenza strains (among those age 65 and older), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile.

Corresponding Author: To contact the corresponding author, Amanda K. Rudman Spergel, MD, email Amanda.RudmanSpergel@modernatx.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.5646)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.5646?guestAccessKey=143c6ea1-0112-4ea2-8e85-b19e45dd9773&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=050725

END

ELSE PRESS RELEASES FROM THIS DATE:

Comb jellies reveal ancient origins of animal genome regulation

2025-05-07

Life depends on genes being switched on and off at exactly the right time. Even the simplest living organisms do this, but usually over short distances across the DNA sequence, with the on/off switch typically right next to a gene. This basic form of genomic regulation is probably as old as life on Earth. A new study published today in Nature by researchers at the Centre for Genomic Regulation (CRG) and the Centre Nacional d’Anàlisi Genòmica (CNAG) finds that the ability to control genes from far away, over many tens of thousands of DNA letters, evolved between 650 and 700 million years ...

Will you live an unprecedented life?

2025-05-07

Climate change's disproportionate burden on youth Climate extremes, including heatwaves, crop failures, river floods, tropical cyclones, wildfires and droughts, will intensify with continued atmospheric warming. Today’s children will endure more climate extremes then any previous generation. “In 2021, we demonstrated how children are to face disproportionate increases in extreme event exposure – especially in low-income countries. Now, we examined where the cumulative exposure to climate extremes across one’s lifetime will far exceed that which would have ...

Study finds teens driving older vehicles have increased risk for fatal crashes

2025-05-07

(COLUMBUS, Ohio) – Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities. Researchers at Nationwide Children’s Hospital reviewed national fatal crash data (2016-2021) and examined the vehicle age and driver assistance technologies of vehicles driven by teen and middle-aged drivers, and their associations with driver deaths during fatal crashes. In a study published today ...

AI Model Improves Delirium Prediction, Leading to Better Health Outcomes for Hospitalized Patients

2025-05-07

New York, NY [May 7, 2025]—An artificial intelligence (AI) model improved outcomes in hospitalized patients by quadrupling the rate of detection and treatment of delirium. The model identifies patients at high risk for delirium and alerts a specially-trained team to assess the patient and create a treatment plan, if needed. The model, developed by researchers at the Icahn School of Medicine at Mount Sinai, has been integrated into hospital operations, helping health care providers identify and manage delirium, a condition that can affect up to one-third of hospitalized ...

Vehicle age and driver assistance technologies in fatal crashes involving teen and middle-aged drivers

2025-05-07

About The Study: The findings of this study suggest that older vehicles and those with fewer driver assistance technologies are associated with increased risk of driver death in fatal crashes; thus, teens should drive the safest vehicles available, not older family cars. The findings underscore the urgent need to ensure teens drive safer vehicles to protect their lives. Corresponding Author: To contact the corresponding author, Jingzhen Yang, PhD, MPH, email ginger.yang@nationwidechildrens.org. To access the embargoed study: Visit our For The Media website ...

Reporting and representation of race and ethnicity in clinical trials of pharmacotherapy for mental disorders

2025-05-07

About The Study: The findings of this meta-analysis suggest that differences in reporting race and ethnicity across geographic locations and underrepresentation of certain racial and ethnic groups in U.S.-based randomized clinical trials highlight the need for international guidelines to ensure equitable recruitment and reporting in clinical trials. Corresponding Author: To contact the corresponding author, Alessio Bellato, PhD, email a.bellato@soton.ac.uk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2025.0666) Editor’s ...

Clinical and neuropathological evaluations of the New Brunswick neurological syndrome of unknown cause

2025-05-07

About The Study: There was no evidence supporting a diagnosis of neurological syndrome of unknown cause (NSUC) in this cohort. The data inclusive of independent examinations and neuropathology strongly supported the presence of several neurodegenerative and non-neurodegenerative conditions. Unfounded concerns that a potentially fatal mystery disease, possibly induced by an environmental toxin, is causing the patients’ neurological symptoms has been amplified in traditional and social media. Second, independent clinical evaluations ...

Childhood brain tumors develop early in highly specialized nerve cells

2025-05-07

Medulloblastoma is one of the most common malignant tumors of the central nervous system (CNS) in children and adolescents. It develops in the area of the cerebellum, which is responsible for movement coordination, among other things. Medulloblastomas enlarge rapidly, often grow into surrounding tissue and can also form metastases. The wide variety of this tumor group also makes it difficult to find the right treatment. A team of researchers at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ) and Heidelberg University ...

A new class of molecules against cancer cells refractory to standard treatments

2025-05-07

Current anticancer treatments essentially target the primary tumour cells that proliferate quickly, but do not effectively eliminate specific cancer cells able to adapt to existing treatments and which exhibit high metastatic potential1. Yet metastases are responsible for 70% of cancer deaths. A French research team from Institut Curie, the CNRS and Inserm has just developed a new class of small molecules that bring about the destruction of cell membranes, and hence triggers cell death. Led by scientists at the Laboratory of Biomedicine (Institut Curie/CNRS/Inserm)2, ...

Neuroscientists pinpoint where (and how) brain circuits are reshaped as we learn new movements

2025-05-07

A landmark study published by scientists at the University of California San Diego is redefining science’s understanding of the way learning takes place. The findings, published in the journal Nature and supported by the National Institutes of Health and U.S. National Science Foundation, provide novel insights on how brain wiring changes during learning periods, offering a path to new therapies and technologies that aid neurological disorders. For many years, neuroscientists have isolated the brain’s primary ...

LAST 30 PRESS RELEASES:

Tracing the quick synthesis of an industrially important catalyst

New software sheds light on cancer’s hidden genetic networks

UT Health San Antonio awarded $3 million in CPRIT grants to bolster cancer research and prevention efforts in South Texas

Manhattan E. Charurat, Ph.D., MHS invested as the Homer and Martha Gudelsky Distinguished Professor in Medicine at the University of Maryland School of Medicine

Insilico Medicine’s Pharma.AI Q4 Winter Launch Recap: Revolutionizing drug discovery with cutting-edge AI innovations, accelerating the path to pharmaceutical superintelligence