Immunogenicity and safety of influenza and COVID-19 multicomponent vaccine in adults age 50 and older

JAMA

2025-05-07

(Press-News.org) About The Study: In this phase 3 study, mRNA-1083, an investigational, multicomponent vaccine against seasonal influenza and SARS-CoV-2, met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64), the 3 clinically relevant influenza strains (among those age 65 and older), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile.

Corresponding Author: To contact the corresponding author, Amanda K. Rudman Spergel, MD, email Amanda.RudmanSpergel@modernatx.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.5646)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Immunogenicity and safety of influenza and COVID-19 multicomponent vaccine in adults age 50 and older

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