(Press-News.org) University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) researchers, who are on faculty at the University of Maryland School of Medicine, presented findings at the American Association for Cancer Research (AACR) Annual Meeting in Chicago last month.
These included a study conducted with researchers at the National Cancer Institute, which evaluated lifetime alcohol consumption and found that current drinkers who drank an average of 14 or more drinks per week throughout adulthood compared to current drinkers who drank less than one drink per week throughout adulthood had a 25 percent higher risk of colorectal cancer, particularly for rectal cancer.
Others tested the safety of a novel immunotherapy treatment in patients with relapsed or refractory acute myeloid leukemia in an early-stage clinical trial. Researchers also presented data that may guide the optimization of CAR T-cell therapy in myeloma patients, leading to greater success and fewer side effects of this promising immunotherapy.
UMGCCC #AACR25 Photo Gallery
AACR25 Highlights
Association of increasing alcohol intake over the lifetime with colorectal adenoma and colorectal cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Caitlin P. O'Connell, Sonja I. Bernd1, Kenechukwu Chudy-Onwugaje, Andrew T. Kunzmann, Wen-Yi Huang, Kathryn Hughes Barry, Erikka Loftfield
Intravenous infusion of the allosteric small molecule STING agonist CRD3874-SI in patients with relapsed or refractory acute myeloid leukemia: A Phase I trial
Maria R. Baer, Vu H. Duong, Oyinkansola Arasanmi, Devon T. Issac, Sunita Philip, Megan Wagner, Ar'Lena Hassan, Feyruz V. Rassool, Sandip Middya, Ritesh Shrivastava, Anindita Middya, Nagaswamy Mane, Thanilsana Soram, Kavita Puniya, Nidhi Rawat, Debjani Chakraborty, Rubeena R. Mansuri, Anul Singh, Rajib Ghosh, Anuj Gautam, Sourav Basu, Monali Banerjee, Arjun Surya
Distinct expansion, phenotype, function, and toxicity of cilta-cel vs. ide-cel CAR T cells in the real world
Djordje Atanackovic, Tim Luetkens, Dina Schneider, Peirong Hu, Xu Wang, Amol C. Shetty, Luke Tallon, Imari Patel, Rohan Singh, Etse Gebru, Rediet Mulatu, Destiny Omili, Daniel Yamoah, Xiaoxuan Fan, Aerielle Matsangos, Patricia Lesho, Kenneth A. Dietze, Ariel A. Fromowitz, Kim Hankey, Saurabh Dahiya, Jean A. Yared, Nancy M. Hardy, Rima Koka, Michael E. Kallen, Ashraf Badros, Aaron P. Rapoport, Mehmet Kocoglu
END
UMGCCC researchers share new findings on link between lifetime alcohol use and colorectal cancer and more at AACR 2025
2025-05-12
ELSE PRESS RELEASES FROM THIS DATE:
Energy from the depths of the Earth: Collaborative research project studies temperature-induced change of rocks in geothermal reservoirs
2025-05-12
Geothermal energy can make a decisive contribution towards the energy revolution in Germany while supporting the changeover from the use of fossil to climate-neutral energy resources. However, to ensure widespread public acceptance, it is essential to reduce associated risks, such as the triggering of earthquakes, as far as possible. A new research project led by Johannes Gutenberg University Mainz (JGU) will investigate the impact of changes in deep geothermal reservoirs caused by contact between hot rock and cold water. "We want to understand the effect of thermally induced fracture ...
Workplace culture, not policies, biggest factor in helping employees disclose mental health concerns: SFU study
2025-05-12
A Simon Fraser University new study is challenging a commonly held misconception that there’s little organizations can do to encourage employees to disclose mental health concerns.
World Health Organization data shows 15 per cent of adults have a mental health concern, while other surveys have found 65 per cent of employees believe mental health concerns interfere with their job. Yet many organizations, even those with mental health supports and programs, see disclosure as a personal decision they have no influence over.
“That’s just not what ...
Olympic anti-doping lab puts U.S. meat supply to the test
2025-05-12
Scientists at UCLA's Olympic Analytical Laboratory turned their sophisticated analytical capabilities for testing athlete samples for performance-enhancing drugs to research examining the U.S. meat supply as part of a study led by Texas Tech. The study was designed to investigate concerns that residues of growth promoters used in meat production could potentially cause athletes to test positive.
The laboratory, which typically searches for prohibited substances in urine and blood samples from elite ...
Study uncovers mystery of how mini sand dunes form
2025-05-12
A new study led by the University of Southampton and research institutes in France has uncovered the mystery of how mini sand dunes form on beaches and in deserts.
While the formation of large desert dunes is well understood, scientists haven’t been able to use the same theory to explain how smaller-scale dunes - the kind you might walk through on a beach holiday, emerge.
The findings, published today [12 May 2025] in the journal PNAS, not only reveal how these so-called ‘proto dunes’ occur on Earth, but could hold clues to how they form on Mars and other planets.
“These are the ...
Study reveals vast Aztec trade networks behind ancient obsidian artifacts
2025-05-12
New archaeological research by Tulane University and the Proyecto Templo Mayor in Mexico reveals how obsidian – a volcanic glass used for tools and ceremonial objects and one of the most important raw materials in pre-Columbian times – moved across ancient Mesoamerica and shaped life in its capital, Tenochtitlan. The study sheds new light on the economic networks, rituals and political influence of the Mexica (Aztec) Empire.
Published this week in Proceedings of the National Academy of Sciences, the study analyzed 788 obsidian artifacts excavated from the Templo Mayor of Tenochtitlan, the main temple and core of the Mexica Empire located in ...
Name diversity sheds light on ancient societies
2025-05-12
A new study has uncovered hidden social patterns in ancient Hebrew kingdoms by analyzing personal names from archaeological findings. Applying diversity statistics typically used in ecological studies, the researchers found that the Kingdom of Israel had a far more diverse onomastic (naming) landscape than Judah—indicating a more open, cosmopolitan society. Over time, name diversity in Judah declined, likely reflecting increasing religious centralization and sociopolitical control. This interdisciplinary approach opens new possibilities for studying ancient cultures using statistical ...
Lower tackle height changing face of women’s rugby, study says
2025-05-12
Lower the legal tackle height in women's rugby is providing effectin in reducing head contacts between players, a world-first study suggests.
Changes to the tackle height law in women’s community rugby in Scotland is linked to reductions in head-to-head and head-to shoulder contacts, the study found.
A study compared more than 11,000 tackles between the 2022/23 season, before the reduced tackle height law was trialed and the 2023/24 season when it was introduced.
Experts found 21 per cent fewer upright tackles and a 34 per cent increase in tacklers entering the tackle bent at the waist, the recommended ...
Lauren Hunt, PhD, RN, FNP, of UCSF recognized with AFAR’s Terrie Fox Wetle Rising Star Award in Health Services and Aging Research
2025-05-12
New York, NY – The American Federation for Aging Research (AFAR), is proud to recognize the outstanding contributions of Lauren Hunt, PhD, RN, FNP, with the 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research.
This award honors a health services researcher in an early or middle phase of his/her career who has already made importantcontributions with work that respects the value of multidisciplinary health services ...
Exploring sex differences in neurological conditions
2025-05-12
Conditions such as Tourette syndrome (TS), schizophrenia, and Attention-Deficit/Hyperactivity Disorder (ADHD) have sex differences with unknown mechanisms. These sex-specific mechanisms may inform the development of more effective treatments. In a new JNeurosci paper, Meghan Van Zandt and Christopher Pittenger used mice to shed light on the mechanisms underlying sex differences in these psychiatric conditions.
Prior to this study, the researchers knew that these neurological disorders are characterized ...
Your fingers wrinkle in the same pattern every time you’re in the water for too long
2025-05-12
Do your wrinkles always form in the same pattern every time you're in the water for too long? According to new research from Binghamton University, State University of New York, the answer is yes.
A couple of years ago, Binghamton University Associate Professor Guy German published research about why human skin wrinkles when you stay in the water too long. Received wisdom held that the water swelled your skin and made your fingers wrinkly, but little to no research had been done to prove that.
What German and his team at the Biological Soft Matter Mechanics Laboratory found is that blood vessels beneath the skin actually contract after prolonged ...