Prognostic and clinicopathological significance of circPVT1 in solid tumors: a systematic review and meta-analysis
2025-05-21
(Press-News.org) Background and objectives
circPVT1 has emerged as a key regulator in disease progression and clinical outcomes. However, its prognostic relevance and association with clinicopathological parameters in solid malignancies remain to be fully elucidated. To address this, we conducted a meta-analysis to elucidate the clinical significance of circPVT1 in solid tumors.
Methods
A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, Embase, the Cochrane Library, and CNKI, with a cutoff date of December 31, 2024. Statistical analyses were conducted using STATA 12.0 to calculate pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs), assessing the impact of circPVT1 expression on overall survival (OS) and its association with clinicopathological characteristics.
Results
This analysis included 27 clinical studies encompassing a total of 2,219 patients. Elevated circPVT1 expression was significantly associated with poorer OS in patients with solid tumors (HR = 1.68, 95% CI: 1.39–2.02, P < 0.001). This association was particularly notable in lung cancer (HR = 2.08, 95% CI: 1.51–2.88, P < 0.001) and osteosarcoma (HR = 1.65, 95% CI: 1.38–1.97, P < 0.001), with similar trends observed in hepatocellular carcinoma, colorectal cancer, and papillary thyroid carcinoma. Furthermore, the increased circPVT1 level was correlated with larger tumor size (OR = 1.36, 95% CI: 1.11–1.67, P = 0.004), lymph node metastasis (OR = 1.56, 95% CI: 1.22–2.00, P < 0.001), distant metastasis (OR = 1.80, 95% CI: 1.10–2.92, P = 0.017), and advanced tumor-node-metastasis stage (OR = 1.84, 95% CI: 1.50–2.25, P < 0.001).
Conclusions
Our meta-analysis indicated that elevated circPVT1 expression levels are closely linked to unfavorable OS in tumor patients. circPVT1 has the potential to act as both a prognostic indicator and a molecular target for solid tumor therapy. Future research should focus on validating these findings through large-scale, multicenter prospective studies to further establish the clinical utility of circPVT1 in cancer management.
Full text:
https://www.xiahepublishing.com/2472-0712/ERHM-2024-00042
The study was recently published in the Exploratory Research and Hypothesis in Medicine.
Exploratory Research and Hypothesis in Medicine (ERHM) publishes original exploratory research articles and state-of-the-art reviews that focus on novel findings and the most recent scientific advances that support new hypotheses in medicine. The journal accepts a wide range of topics, including innovative diagnostic and therapeutic modalities as well as insightful theories related to the practice of medicine. The exploratory research published in ERHM does not necessarily need to be comprehensive and conclusive, but the study design must be solid, the methodologies must be reliable, the results must be true, and the hypothesis must be rational and justifiable with evidence.
Follow us on X: @xiahepublishing
Follow us on LinkedIn: Xia & He Publishing Inc.
END
ELSE PRESS RELEASES FROM THIS DATE:
2025-05-21
VINCI. Italy — For over five centuries, Leonardo Da Vinci has been celebrated as a visionary artist, scientist, and inventor, known for his extraordinary talent and groundbreaking experiments. Today, an international collaboration known as the Leonardo DNA Project is closer than ever to uncovering the biological secrets of the greatest genius of the Renaissance.
In their new book “Genìa Da Vinci. Genealogy and Genetics for Leonardo’s DNA,” published by Angelo Pontecorboli Editore, experts Alessandro Vezzosi and Agnese Sabato of the Leonardo Da Vinci Heritage ...
2025-05-21
Wednesday, May 21, 2025, CLEVELAND: Cleveland Clinic has been awarded a $5 million grant from the Cystic Fibrosis Foundation to continue its role as the Biorepository Coordinating Center for the Cystic Fibrosis Lung Transplant Consortium until 2030. The coordinating center provides the infrastructure to support research to improve understanding of the factors that affect lung transplant outcomes.
The initiative, which includes 15 participating institutions in North America, is led by Maryam Valapour, M.D., M.P.P., director of Lung Transplant Outcomes at Cleveland Clinic, and Suzy Comhair, Ph.D., scientific director of Cleveland ...
2025-05-21
NEW ORLEANS, May 21, 2025 – When pollinators visit flowers, they produce a variety of characteristic sounds, from wing flapping during hovering, to landing and takeoff. However, these sounds are extremely small compared to other vibrations and acoustics of insect life, causing researchers to overlook these insects’ acoustic signals often related to wing and body buzzing.
Francesca Barbero, a professor of zoology at the University of Turin, and her collaborators — an interdisciplinary mix of entomologists, sound engineers, and plant physiologists ...
2025-05-21
An international study led by the University of Colorado Cancer Center has uncovered why a widely used treatment for acute myeloid leukemia (AML) doesn’t work for everyone. The findings could help doctors better match patients with the therapies most likely to work for them.
The study was published today in Blood Cancer Discovery.
Researchers analyzed data from 678 AML patients, the largest group studied to date for this treatment and found that both gene mutations and the maturity of leukemia cells affect ...
2025-05-21
PULLMAN, Wash. – The way people express emotions while helping others can influence whether their assistance is welcomed, resented, or reciprocated, according to new research from Washington State University’s Carson College of Business.
The study, led by Stephen Lee, assistant professor of management, found that helpers who express emotions like gratitude and sympathy are more likely to be seen as having genuine motives and are more likely to foster trust and future collaboration. Conversely, when helpers display pride or contempt, their motives are often questioned, weakening relationships and reducing the likelihood of reciprocation.
“In ...
2025-05-21
Highlights:
Antimicrobial resistance is a growing issue in aquaculture.
Vaccines don’t work on fish larvae because they have no developed immune system, so alternatives are necessary.
Researchers in Denmark discovered that mixtures of bacteria from live-feed microalgae are capable of inhibiting fish pathogens.
Washington, D.C.—A new study by Danish researchers has demonstrated that it is possible to develop a consortium of bacteria that can inhibit bacterial pathogens in aquaculture. This could potentially reduce ...
2025-05-21
Herndon, VA, May 21, 2025 -- Hurricane winds are a major contributor to storm-related losses for people living in the southeastern coastal states. As the global temperature continues to rise, scientists predict that hurricanes will get more destructive -- packing higher winds and torrential rainfall. A new study, published in the journal Risk Analysis, projects that wind losses for homeowners in the Southeastern coastal states could be 76 percent higher by the year 2060 and 102 percent higher by 2100.
University of Illinois civil engineer ...
2025-05-21
World renowned pulmonologists and experts in respiratory medicine from the Mount Sinai Health System will present new research at the American Thoracic Society (ATS) 2025 International Conference in San Francisco from May 18–May 21. Please let me know if you would like to coordinate an interview about their work. Mount Sinai doctors and researchers are also available to comment on breaking news and trending topics.
Sessions and Symposiums
*All abstracts listed below are under embargo until the scheduled ...
2025-05-21
In a new study, researchers from Intermountain Health in Salt Lake City have shown that by using a computerized clinical decision support tool to guide diagnosis and treatment in emergency department patients with pneumonia, they were able to reduce mortality rates, especially in patients experiencing socioeconomic hardships.
Pneumonia, a serious infection in the lungs that causes inflammation and difficulty breathing, is one of the most common causes of death worldwide. An estimated 150,000 people are hospitalized annually for pneumococcal pneumonia, ...
2025-05-21
A mechanism involving potassium channels in the brain that control brain cell activity could provide a new and fundamentally different way of treating depression symptoms in adults with major depressive disorder, according to two complementary papers published recently by researchers at the Icahn School of Medicine at Mount Sinai.
In two new research articles, published in Biological Psychiatry and Molecular Psychiatry, the researchers provide new insights into how a drug called ezogabine may impact the brain to improve depression.
“Depression is a devastating ...
LAST 30 PRESS RELEASES:
[Press-News.org] Prognostic and clinicopathological significance of circPVT1 in solid tumors: a systematic review and meta-analysis
