Decline in US drug overdose deaths by region, substance, and demographics

JAMA Network Open

2025-06-12

(Press-News.org) About The Study: In this cross-sectional study, U.S. drug overdose death rates entered a new wave of sustained deceleration in 2023 after 2 decades of increase. This shift may reflect changes in drug markets, treatment access, harm reduction efforts, and population-level risk. Although the decline is encouraging, persistent disparities highlight the need for targeted interventions and improved understanding of the underlying drivers.

Corresponding Author: To contact the corresponding author, Lori Ann Post, PhD, email lori.post@northwestern.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.14997)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Decline in US drug overdose deaths by region, substance, and demographics

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